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84 results

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Page 1
Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial.
West H, McCleod M, Hussein M, Morabito A, Rittmeyer A, Conter HJ, Kopp HG, Daniel D, McCune S, Mekhail T, Zer A, Reinmuth N, Sadiq A, Sandler A, Lin W, Ochi Lohmann T, Archer V, Wang L, Kowanetz M, Cappuzzo F. West H, et al. Among authors: mccune s. Lancet Oncol. 2019 Jul;20(7):924-937. doi: 10.1016/S1470-2045(19)30167-6. Epub 2019 May 20. Lancet Oncol. 2019. PMID: 31122901 Clinical Trial.
Patients were randomly assigned (2:1; permuted block [block size of six] with an interactive voice or web response system) to receive atezolizumab (1200 mg intravenously every 3 weeks) plus chemotherapy (carboplatin [area under the curve 6 mg/mL per min every 3 weeks] plus nab-pa …
Patients were randomly assigned (2:1; permuted block [block size of six] with an interactive voice or web response system) to receive atezol …
Prednisolone or pentoxifylline for alcoholic hepatitis.
Thursz MR, Richardson P, Allison M, Austin A, Bowers M, Day CP, Downs N, Gleeson D, MacGilchrist A, Grant A, Hood S, Masson S, McCune A, Mellor J, O'Grady J, Patch D, Ratcliffe I, Roderick P, Stanton L, Vergis N, Wright M, Ryder S, Forrest EH; STOPAH Trial. Thursz MR, et al. Among authors: mccune a. N Engl J Med. 2015 Apr 23;372(17):1619-28. doi: 10.1056/NEJMoa1412278. N Engl J Med. 2015. PMID: 25901427 Free article. Clinical Trial.
A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.
Hassan AO, Kafai NM, Dmitriev IP, Fox JM, Smith BK, Harvey IB, Chen RE, Winkler ES, Wessel AW, Case JB, Kashentseva E, McCune BT, Bailey AL, Zhao H, VanBlargan LA, Dai YN, Ma M, Adams LJ, Shrihari S, Danis JE, Gralinski LE, Hou YJ, Schäfer A, Kim AS, Keeler SP, Weiskopf D, Baric RS, Holtzman MJ, Fremont DH, Curiel DT, Diamond MS. Hassan AO, et al. Among authors: mccune bt. Cell. 2020 Oct 1;183(1):169-184.e13. doi: 10.1016/j.cell.2020.08.026. Epub 2020 Aug 19. Cell. 2020. PMID: 32931734 Free PMC article.
Extending Gene Medicines to All in Need.
McCune JM, Kiem HP. McCune JM, et al. N Engl J Med. 2024 May 9;390(18):1721-1722. doi: 10.1056/NEJMe2403104. Epub 2024 Apr 24. N Engl J Med. 2024. PMID: 38657269 No abstract available.
Tissue-Mimetic Supramolecular Polymer Networks for Bioelectronics.
O'Neill SJK, Huang Z, Ahmed MH, Boys AJ, Velasco-Bosom S, Li J, Owens RM, McCune JA, Malliaras GG, Scherman OA. O'Neill SJK, et al. Among authors: mccune ja. Adv Mater. 2023 Jan;35(1):e2207634. doi: 10.1002/adma.202207634. Epub 2022 Nov 28. Adv Mater. 2023. PMID: 36314408
Rational design of an ultrahigh affinity host-guest ternary complex led to binding affinities (>10(13) M(-2) ) of over an order of magnitude greater than previous reports. Embedding these complexes as dynamic cross-links, coupled with in situ synthesis of a conducting p …
Rational design of an ultrahigh affinity host-guest ternary complex led to binding affinities (>10(13) M(-2) ) of over an order of …
Potently neutralizing and protective human antibodies against SARS-CoV-2.
Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schäfer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Shrihari S, Mueller BK, Meiler J, Chandrashekar A, Mercado NB, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, McCune BT, Keeler SP, Holtzman MJ, Barouch DH, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE Jr. Zost SJ, et al. Among authors: mccune bt. Nature. 2020 Aug;584(7821):443-449. doi: 10.1038/s41586-020-2548-6. Epub 2020 Jul 15. Nature. 2020. PMID: 32668443 Free PMC article.
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.
Winkler ES, Bailey AL, Kafai NM, Nair S, McCune BT, Yu J, Fox JM, Chen RE, Earnest JT, Keeler SP, Ritter JH, Kang LI, Dort S, Robichaud A, Head R, Holtzman MJ, Diamond MS. Winkler ES, et al. Among authors: mccune bt. Nat Immunol. 2020 Nov;21(11):1327-1335. doi: 10.1038/s41590-020-0778-2. Epub 2020 Aug 24. Nat Immunol. 2020. PMID: 32839612 Free PMC article.
SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2.
Lu Q, Liu J, Zhao S, Gomez Castro MF, Laurent-Rolle M, Dong J, Ran X, Damani-Yokota P, Tang H, Karakousi T, Son J, Kaczmarek ME, Zhang Z, Yeung ST, McCune BT, Chen RE, Tang F, Ren X, Chen X, Hsu JCC, Teplova M, Huang B, Deng H, Long Z, Mudianto T, Jin S, Lin P, Du J, Zang R, Su TT, Herrera A, Zhou M, Yan R, Cui J, Zhu J, Zhou Q, Wang T, Ma J, Koralov SB, Zhang Z, Aifantis I, Segal LN, Diamond MS, Khanna KM, Stapleford KA, Cresswell P, Liu Y, Ding S, Xie Q, Wang J. Lu Q, et al. Among authors: mccune bt. Immunity. 2021 Jun 8;54(6):1304-1319.e9. doi: 10.1016/j.immuni.2021.05.006. Epub 2021 May 9. Immunity. 2021. PMID: 34048708 Free PMC article.
Biomimetic Entropy-Dominant Molecular Hinges with Picomolar Affinity.
Huang Z, Groombridge AS, Wu G, Olesińska M, Chen X, McCune JA, Scherman OA. Huang Z, et al. Among authors: mccune ja. J Am Chem Soc. 2024 Sep 4;146(35):24244-24249. doi: 10.1021/jacs.4c05274. Epub 2024 Aug 21. J Am Chem Soc. 2024. PMID: 39167697 Free PMC article.
Here, we employ host-enhanced intramolecular charge-transfer interactions to mediate entropy-favored complexation between a flexible AB(2)-type guest and a macrocyclic host, forming a new type of molecular hinge with an ultrahigh picomolar binding affinity (K(a) > 10(12) M
Here, we employ host-enhanced intramolecular charge-transfer interactions to mediate entropy-favored complexation between a flexible AB(2)-t …
84 results