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Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex.
Damian M, Mary S, Maingot M, M'Kadmi C, Gagne D, Leyris JP, Denoyelle S, Gaibelet G, Gavara L, Garcia de Souza Costa M, Perahia D, Trinquet E, Mouillac B, Galandrin S, Galès C, Fehrentz JA, Floquet N, Martinez J, Marie J, Banères JL. Damian M, et al. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1601-6. doi: 10.1073/pnas.1414618112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605885 Free PMC article.
Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling.
M'Kadmi C, Leyris JP, Onfroy L, Galés C, Saulière A, Gagne D, Damian M, Mary S, Maingot M, Denoyelle S, Verdié P, Fehrentz JA, Martinez J, Banères JL, Marie J. M'Kadmi C, et al. J Biol Chem. 2015 Nov 6;290(45):27021-27039. doi: 10.1074/jbc.M115.659250. Epub 2015 Sep 11. J Biol Chem. 2015. PMID: 26363071 Free PMC article.
GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.
Damian M, Pons V, Renault P, M'Kadmi C, Delort B, Hartmann L, Kaya AI, Louet M, Gagne D, Ben Haj Salah K, Denoyelle S, Ferry G, Boutin JA, Wagner R, Fehrentz JA, Martinez J, Marie J, Floquet N, Galès C, Mary S, Hamm HE, Banères JL. Damian M, et al. Among authors: m kadmi c. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4501-4506. doi: 10.1073/pnas.1712725115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632174 Free PMC article.
Structure and dynamics of G protein-coupled receptor-bound ghrelin reveal the critical role of the octanoyl chain.
Ferré G, Louet M, Saurel O, Delort B, Czaplicki G, M'Kadmi C, Damian M, Renault P, Cantel S, Gavara L, Demange P, Marie J, Fehrentz JA, Floquet N, Milon A, Banères JL. Ferré G, et al. Among authors: m kadmi c. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17525-17530. doi: 10.1073/pnas.1905105116. Epub 2019 Aug 15. Proc Natl Acad Sci U S A. 2019. PMID: 31416915 Free PMC article.
Development of Nonpeptidic Inverse Agonists of the Ghrelin Receptor (GHSR) Based on the 1,2,4-Triazole Scaffold.
Haj Salah KB, Maingot M, Blayo AL, M'Kadmi C, Damian M, Mary S, Cantel S, Neasta J, Oiry C, Péraldi-Roux S, Fernandez G, Romero GG, Perello M, Marie J, Banères JL, Fehrentz JA, Denoyelle S. Haj Salah KB, et al. Among authors: m kadmi c. J Med Chem. 2020 Oct 8;63(19):10796-10815. doi: 10.1021/acs.jmedchem.9b02122. Epub 2020 Sep 21. J Med Chem. 2020. PMID: 32882134
26 results