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Vascular heterogeneity and specialization in development and disease.
Potente M, Mäkinen T. Potente M, et al. Nat Rev Mol Cell Biol. 2017 Aug;18(8):477-494. doi: 10.1038/nrm.2017.36. Epub 2017 May 24. Nat Rev Mol Cell Biol. 2017. PMID: 28537573 Review.
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
Mäkinen T, Jussila L, Veikkola T, Karpanen T, Kettunen MI, Pulkkanen KJ, Kauppinen R, Jackson DG, Kubo H, Nishikawa S, Ylä-Herttuala S, Alitalo K. Mäkinen T, et al. Nat Med. 2001 Feb;7(2):199-205. doi: 10.1038/84651. Nat Med. 2001. PMID: 11175851
Lymphatic endothelium: a new frontier of metastasis research.
Karkkainen MJ, Mäkinen T, Alitalo K. Karkkainen MJ, et al. Nat Cell Biol. 2002 Jan;4(1):E2-5. doi: 10.1038/ncb0102-e2. Nat Cell Biol. 2002. PMID: 11780131 Review.
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.
Petrova TV, Mäkinen T, Mäkelä TP, Saarela J, Virtanen I, Ferrell RE, Finegold DN, Kerjaschki D, Ylä-Herttuala S, Alitalo K. Petrova TV, et al. EMBO J. 2002 Sep 2;21(17):4593-9. doi: 10.1093/emboj/cdf470. EMBO J. 2002. PMID: 12198161 Free PMC article.
Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.
Dixelius J, Makinen T, Wirzenius M, Karkkainen MJ, Wernstedt C, Alitalo K, Claesson-Welsh L. Dixelius J, et al. J Biol Chem. 2003 Oct 17;278(42):40973-9. doi: 10.1074/jbc.M304499200. Epub 2003 Jul 24. J Biol Chem. 2003. PMID: 12881528
Vegfc is required for vascular development and endoderm morphogenesis in zebrafish.
Ober EA, Olofsson B, Mäkinen T, Jin SW, Shoji W, Koh GY, Alitalo K, Stainier DY. Ober EA, et al. EMBO Rep. 2004 Jan;5(1):78-84. doi: 10.1038/sj.embor.7400047. EMBO Rep. 2004. PMID: 14710191 Free PMC article.
Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis.
He Y, Rajantie I, Ilmonen M, Makinen T, Karkkainen MJ, Haiko P, Salven P, Alitalo K. He Y, et al. Cancer Res. 2004 Jun 1;64(11):3737-40. doi: 10.1158/0008-5472.CAN-04-0088. Cancer Res. 2004. PMID: 15172976
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.
Mäkinen T, Adams RH, Bailey J, Lu Q, Ziemiecki A, Alitalo K, Klein R, Wilkinson GA. Mäkinen T, et al. Genes Dev. 2005 Feb 1;19(3):397-410. doi: 10.1101/gad.330105. Genes Dev. 2005. PMID: 15687262 Free PMC article.
Regulation of lymphangiogenesis--from cell fate determination to vessel remodeling.
Karpanen T, Mäkinen T. Karpanen T, et al. Exp Cell Res. 2006 Mar 10;312(5):575-83. doi: 10.1016/j.yexcr.2005.10.034. Epub 2005 Dec 15. Exp Cell Res. 2006. PMID: 16343484 Review.
Lymphatic vasculature: a molecular perspective.
Hosking B, Makinen T. Hosking B, et al. Bioessays. 2007 Dec;29(12):1192-202. doi: 10.1002/bies.20672. Bioessays. 2007. PMID: 18008374 Review.
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