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Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo.
Erlandsson L, Licence S, Gaspal F, Lane P, Corcoran AE, Mårtensson IL. Erlandsson L, et al. Among authors: Martensson IL. Eur J Immunol. 2005 Jun;35(6):1969-76. doi: 10.1002/eji.200425821. Eur J Immunol. 2005. PMID: 15909309
At this pre-BII cell stage, the IL-7Ralpha is also expressed. Some in vitro studies suggest that pre-BCR-dependent expansion relies on the IL-7Ralpha, and others that it does not. It has also been suggested that the pre-BCR mediates down-regulation of the IL-7Ralpha. However, the in vivo relationship between the pre-BCR and the IL-7Ralpha has not been previously examined. ...
At this pre-BII cell stage, the IL-7Ralpha is also expressed. Some in vitro studies suggest that pre-BCR-dependent expansion relies o …
MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.
Mok Y, Schwierzeck V, Thomas DC, Vigorito E, Rayner TF, Jarvis LB, Prosser HM, Bradley A, Withers DR, Mårtensson IL, Corcoran LM, Blenkiron C, Miska EA, Lyons PA, Smith KGC. Mok Y, et al. Among authors: Martensson IL. J Immunol. 2013 Sep 15;191(6):3037-3048. doi: 10.4049/jimmunol.1301289. Epub 2013 Aug 19. J Immunol. 2013. PMID: 23960236 Free PMC article.
Censoring of autoreactive B cell development by the pre-B cell receptor.
Keenan RA, De Riva A, Corleis B, Hepburn L, Licence S, Winkler TH, Mårtensson IL. Keenan RA, et al. Among authors: Martensson IL. Science. 2008 Aug 1;321(5889):696-9. doi: 10.1126/science.1157533. Epub 2008 Jun 19. Science. 2008. PMID: 18566249
The pre-B-cell receptor.
Mårtensson IL, Keenan RA, Licence S. Mårtensson IL, et al. Curr Opin Immunol. 2007 Apr;19(2):137-42. doi: 10.1016/j.coi.2007.02.006. Epub 2007 Feb 15. Curr Opin Immunol. 2007. PMID: 17306522 Review.
The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.
Parker MJ, Licence S, Erlandsson L, Galler GR, Chakalova L, Osborne CS, Morgan G, Fraser P, Jumaa H, Winkler TH, Skok J, Mårtensson IL. Parker MJ, et al. Among authors: Martensson IL. EMBO J. 2005 Nov 16;24(22):3895-905. doi: 10.1038/sj.emboj.7600850. Epub 2005 Nov 10. EMBO J. 2005. PMID: 16281060 Free PMC article.
Impaired B-1 and B-2 B cell development and atypical splenic B cell structures in IL-7 receptor-deficient mice.
Erlandsson L, Licence S, Gaspal F, Bell S, Lane P, Corcoran AE, Mårtensson IL. Erlandsson L, et al. Among authors: Martensson IL. Eur J Immunol. 2004 Dec;34(12):3595-603. doi: 10.1002/eji.200425217. Eur J Immunol. 2004. PMID: 15495160
The cytokine IL-7 and its receptor are essential for normal B and T lymphopoiesis. We have analyzed the role of this receptor in B cell development throughout ontogeny in IL-7 receptor alpha-deficient mice. ...The impairment of marginal zone and B-1 B cells in IL-7 receptor- but not IL-7-deficient mice suggests non-redundant functions for the IL-7 receptor ligands, IL-7 and thymic stromal lymphopoietin....
The cytokine IL-7 and its receptor are essential for normal B and T lymphopoiesis. We have analyzed the role of this receptor in B ce …
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