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Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics.
Pedersen MF, Wróbel TM, Märcher-Rørsted E, Pedersen DS, Møller TC, Gabriele F, Pedersen H, Matosiuk D, Foster SR, Bouvier M, Bräuner-Osborne H. Pedersen MF, et al. Among authors: moller tc. Neuropharmacology. 2020 Apr;166:107718. doi: 10.1016/j.neuropharm.2019.107718. Epub 2019 Jul 24. Neuropharmacology. 2020. PMID: 31351108 Free article.
GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats.
van der Velden WJC, Smit FX, Christiansen CB, Møller TC, Hjortø GM, Larsen O, Schiellerup SP, Bräuner-Osborne H, Holst JJ, Hartmann B, Frimurer TM, Rosenkilde MM. van der Velden WJC, et al. Among authors: moller tc. ACS Pharmacol Transl Sci. 2021 Jan 19;4(1):296-313. doi: 10.1021/acsptsci.0c00193. eCollection 2021 Feb 12. ACS Pharmacol Transl Sci. 2021. PMID: 33615180 Free PMC article.
23 results