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Comparison of the synaptosomal uptake inhibition of serotonin by St John's wort products.
Schulte-Löbbert S, Holoubek G, Müller WE, Schubert-Zsilavecz M, Wurglics M. Schulte-Löbbert S, et al. J Pharm Pharmacol. 2004 Jun;56(6):813-8. doi: 10.1211/0022357023493. J Pharm Pharmacol. 2004. PMID: 15231048
Modulation of P-glycoprotein function by St John's wort extract and its major constituents.
Weber CC, Kressmann S, Fricker G, Müller WE. Weber CC, et al. Pharmacopsychiatry. 2004 Nov;37(6):292-8. doi: 10.1055/s-2004-832686. Pharmacopsychiatry. 2004. PMID: 15551196
METHODS: We characterized the modulatory potencies in two in vitro assays using calcein-AM, first in VLB cells (a human lymphocytic leukemia cell line expressing Pgp) and second in PBCEC cells (porcine brain capillary endothelial cells). ...
METHODS: We characterized the modulatory potencies in two in vitro assays using calcein-AM, first in VLB cells (a human lymphocytic l …
Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort.
Wonnemann M, Singer A, Siebert B, Müller WE. Wonnemann M, et al. Pharmacopsychiatry. 2001 Jul;34 Suppl 1:S148-51. doi: 10.1055/s-2001-15465. Pharmacopsychiatry. 2001. PMID: 11518066
In our previous investigations, we could demonstrate that extract preparations of Hypericum perforatum (St. John's wort, SJW) inhibit the uptake of several neurotransmitters (serotonin, norepinephrine, dopamine, GABA, L-glutamate) in synaptosomal preparations of rodent bra …
In our previous investigations, we could demonstrate that extract preparations of Hypericum perforatum (St. John's wort, SJW) inhibit …
Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1.
Singer A, Wonnemann M, Müller WE. Singer A, et al. J Pharmacol Exp Ther. 1999 Sep;290(3):1363-8. J Pharmacol Exp Ther. 1999. PMID: 10454515
As monensin decreases serotonin uptake by increasing Na(+)/H(+) exchange, we compared the effects of hyperforin and monensin on the free intracellular sodium concentration ([Na(+)](i)) in platelets by measuring 1,3-benzenedicarboxylic acid, 4,4'-[1,4,10-trioxa-7, 13-diazac …
As monensin decreases serotonin uptake by increasing Na(+)/H(+) exchange, we compared the effects of hyperforin and monensin on the f …
Hyperforin as a possible antidepressant component of hypericum extracts.
Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE. Chatterjee SS, et al. Life Sci. 1998;63(6):499-510. doi: 10.1016/s0024-3205(98)00299-9. Life Sci. 1998. PMID: 9718074
We demonstrate that the phloroglucinol derivative hyperforin is not only the major lipophilic chemical constituent of the medicinal plant Hypericum perforatum (St. ...
We demonstrate that the phloroglucinol derivative hyperforin is not only the major lipophilic chemical constituent of the medicinal p
Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity.
Müller WE, Rolli M, Schäfer C, Hafner U. Müller WE, et al. Pharmacopsychiatry. 1997 Sep;30 Suppl 2:102-7. doi: 10.1055/s-2007-979528. Pharmacopsychiatry. 1997. PMID: 9342769
Since the mechanism of the antidepressant activity of hypericum extract is not yet understood, we tested possible effects of standardized hypericum extract (LI 160) in several biochemical models relevant for the mechanism of action of other antidepressant drugs. ...
Since the mechanism of the antidepressant activity of hypericum extract is not yet understood, we tested possible effects of standard …
Hyperforin--antidepressant activity by a novel mechanism of action.
Müller WE, Singer A, Wonnemann M. Müller WE, et al. Pharmacopsychiatry. 2001 Jul;34 Suppl 1:S98-102. doi: 10.1055/s-2001-15512. Pharmacopsychiatry. 2001. PMID: 11518085
Inhibition of synaptosomal uptake of 3H-L-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's Wort: the role of amiloride sensitive sodium conductive pathways.
Wonnemann M, Singer A, Müller WE. Wonnemann M, et al. Neuropsychopharmacology. 2000 Aug;23(2):188-97. doi: 10.1016/S0893-133X(00)00102-0. Neuropsychopharmacology. 2000. PMID: 10882845
We have recently shown that hyperforin, a major active constituent of St. John's Wort, not only inhibits the neuronal uptake of serotonin, norepinephrine and dopamine, but also that of L-glutamate and GABA. ...
We have recently shown that hyperforin, a major active constituent of St. John's Wort, not only inhibits the neuronal uptake of serot
[Mechanism of action of St. Johns wort extract].
Müller WE, Singer A, Wonnemann M. Müller WE, et al. Praxis (Bern 1994). 2000 Dec 14;89(50):2111-21. Praxis (Bern 1994). 2000. PMID: 11155494 Review. German.
Like other working parties, we were only able to identify a weak inhibitory effect of the extract and the pure substance hypericin on the monoamine oxidases A and B. ...
Like other working parties, we were only able to identify a weak inhibitory effect of the extract and the pure substance hypericin on …
1,278 results
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