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Site-directed mutagenesis of putative active-site amino acid residues of 3,2-trans-enoyl-CoA isomerase, conserved within the low-homology isomerase/hydratase enzyme family.
Müller-Newen G, Stoffel W. Müller-Newen G, et al. Biochemistry. 1993 Oct 26;32(42):11405-12. doi: 10.1021/bi00093a018. Biochemistry. 1993. PMID: 8218206
Mitochondrial 3-2trans-Enoyl-CoA isomerase. Purification, cloning, expression, and mitochondrial import of the key enzyme of unsaturated fatty acid beta-oxidation.
Müller-Newen G, Stoffel W. Müller-Newen G, et al. Biol Chem Hoppe Seyler. 1991 Aug;372(8):613-24. doi: 10.1515/bchm3.1991.372.2.613. Biol Chem Hoppe Seyler. 1991. PMID: 1958319
Enoyl-CoA hydratase and isomerase form a superfamily with a common active-site glutamate residue.
Müller-Newen G, Janssen U, Stoffel W. Müller-Newen G, et al. Eur J Biochem. 1995 Feb 15;228(1):68-73. doi: 10.1111/j.1432-1033.1995.tb20230.x. Eur J Biochem. 1995. PMID: 7883013
Soluble human interleukin-6 receptor. Expression in insect cells, purification and characterization.
Weiergräber O, Hemmann U, Küster A, Müller-Newen G, Schneider J, Rose-John S, Kurschat P, Brakenhoff JP, Hart MH, Stabel S, et al. Weiergräber O, et al. Eur J Biochem. 1995 Dec 1;234(2):661-9. doi: 10.1111/j.1432-1033.1995.661_b.x. Eur J Biochem. 1995. PMID: 8536717
Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing.
Müller-Newen G, Köhne C, Keul R, Hemmann U, Müller-Esterl W, Wijdenes J, Brakenhoff JP, Hart MH, Heinrich PC. Müller-Newen G, et al. Eur J Biochem. 1996 Mar 15;236(3):837-42. doi: 10.1111/j.1432-1033.1996.00837.x. Eur J Biochem. 1996. PMID: 8665902
The signal transducer gp130--bacterial expression, refolding and properties of the carboxy-terminal domain of the cytokine-binding module.
Müller-Newen G, Pflanz S, Hassiepen U, Stahl J, Wollmer A, Heinrich PC, Grötzinger J. Müller-Newen G, et al. Eur J Biochem. 1997 Jul 1;247(1):425-31. doi: 10.1111/j.1432-1033.1997.00425.x. Eur J Biochem. 1997. PMID: 9249056
Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis.
Tacken I, Dahmen H, Boisteau O, Minvielle S, Jacques Y, Grötzinger J, Küster A, Horsten U, Blanc C, Montero-Julian FA, Heinrich PC, Müller-Newen G. Tacken I, et al. Eur J Biochem. 1999 Oct;265(2):645-55. doi: 10.1046/j.1432-1327.1999.00755.x. Eur J Biochem. 1999. PMID: 10504396
A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor.
Timmermann A, Küster A, Kurth I, Heinrich PC, Müller-Newen G. Timmermann A, et al. Eur J Biochem. 2002 Jun;269(11):2716-26. doi: 10.1046/j.1432-1033.2002.02941.x. Eur J Biochem. 2002. PMID: 12047380
Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies.
Wijdenes J, Heinrich PC, Müller-Newen G, Roche C, Gu ZJ, Clément C, Klein B. Wijdenes J, et al. Eur J Immunol. 1995 Dec;25(12):3474-81. doi: 10.1002/eji.1830251240. Eur J Immunol. 1995. PMID: 8566040
Interleukin-6 and related cytokines: effect on the acute phase reaction.
Heinrich PC, Horn F, Graeve L, Dittrich E, Kerr I, Müller-Newen G, Grötzinger J, Wollmer A. Heinrich PC, et al. Z Ernahrungswiss. 1998;37 Suppl 1:43-9. Z Ernahrungswiss. 1998. PMID: 9558728 Review.
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