Electron withdrawing group-dependent substrate inhibition of an α-ketoamide reductase from Saccharomyces cerevisiae.
Akbary Z, Yu H, Lorenzo I, Paez K, Lee ND, DeBeVoise K, Moses J, Sanders N, Connors N, Cassano A.
Akbary Z, et al.
Biochem Biophys Res Commun. 2023 Oct 8;676:97-102. doi: 10.1016/j.bbrc.2023.07.030. Epub 2023 Jul 15.
Biochem Biophys Res Commun. 2023.
PMID: 37499370
Kinetic studies revealed that AKR 163 experiences strong substrate inhibition by substrates containing halogen atoms or other electron withdrawing groups adjacent to the reactive carbonyl, with K(i) values ranging from 0.29 to 0.6 mM and K(M) values ranging from 0.38 to 0. …
Kinetic studies revealed that AKR 163 experiences strong substrate inhibition by substrates containing halogen atoms or other electron withd …