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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
1966 1
1967 1
1968 1
1972 1
1974 1
1975 6
1976 4
1977 7
1978 3
1979 12
1980 11
1981 8
1982 7
1983 15
1984 14
1985 12
1986 9
1987 11
1988 11
1989 24
1990 19
1991 20
1992 20
1993 19
1994 19
1995 17
1996 21
1997 21
1998 24
1999 26
2000 27
2001 28
2002 31
2003 24
2004 33
2005 34
2006 25
2007 34
2008 39
2009 47
2010 49
2011 77
2012 76
2013 54
2014 83
2015 103
2016 97
2017 103
2018 101
2019 66
2020 64
2021 76
2022 80
2023 74
2024 61

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1,711 results

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Page 1
Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): a multicentre, single-arm, phase 2 trial.
Shimada K, Yamaguchi M, Atsuta Y, Matsue K, Sato K, Kusumoto S, Nagai H, Takizawa J, Fukuhara N, Nagafuji K, Miyazaki K, Ohtsuka E, Okamoto M, Sugita Y, Uchida T, Kayukawa S, Wake A, Ennishi D, Kondo Y, Izumi T, Kin Y, Tsukasaki K, Hashimoto D, Yuge M, Yanagisawa A, Kuwatsuka Y, Shimada S, Masaki Y, Niitsu N, Kiyoi H, Suzuki R, Tokunaga T, Nakamura S, Kinoshita T. Shimada K, et al. Among authors: nagai h. Lancet Oncol. 2020 Apr;21(4):593-602. doi: 10.1016/S1470-2045(20)30059-0. Epub 2020 Mar 11. Lancet Oncol. 2020. PMID: 32171071 Clinical Trial.
Patients received three cycles of R-CHOP (rituximab 375 mg/m(2) intravenously on day 1 [except cycle one, which was on day 8]; cyclophosphamide 750 mg/m(2), doxorubicin 50 mg/m(2), and vincristine 1.4 mg/m(2) [maximum 2.0 mg] intravenously on day 1 of …
Patients received three cycles of R-CHOP (rituximab 375 mg/m(2) intravenously on day 1 [except cycle one, which was on day 8]; cyclop …
Tumor-infiltrating monocytic myeloid-derived suppressor cells contribute to the development of an immunosuppressive tumor microenvironment in gastric cancer.
Tsutsumi C, Ohuchida K, Katayama N, Yamada Y, Nakamura S, Okuda S, Otsubo Y, Iwamoto C, Torata N, Horioka K, Shindo K, Mizuuchi Y, Ikenaga N, Nakata K, Nagai E, Morisaki T, Oda Y, Nakamura M. Tsutsumi C, et al. Among authors: nagai e. Gastric Cancer. 2024 Mar;27(2):248-262. doi: 10.1007/s10120-023-01456-4. Epub 2024 Jan 13. Gastric Cancer. 2024. PMID: 38217732
Additionally, M-MDSCs in GC tissues expressed significantly higher levels of these markers than adjacent normal tissues. ...IER3(+) M-MDSCs expressed higher levels of genes with immunosuppressive functions than IER3(-) M-MDSCs and were abundant in treatment-r …
Additionally, M-MDSCs in GC tissues expressed significantly higher levels of these markers than adjacent normal tissues. ...IER3(+) …
Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study.
Ohtake S, Miyawaki S, Fujita H, Kiyoi H, Shinagawa K, Usui N, Okumura H, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R. Ohtake S, et al. Among authors: nagai t. Blood. 2011 Feb 24;117(8):2358-65. doi: 10.1182/blood-2010-03-273243. Epub 2010 Aug 6. Blood. 2011. PMID: 20693429 Free article. Clinical Trial.
They were randomly assigned to receive either daunorubicin (50 mg/m(2) daily for 5 days) or idarubicin (12 mg/m(2) daily for 3 days) in combination with 100 mg/m(2) of cytarabine by continuous infusion daily for 7 days as induction therapy. ...
They were randomly assigned to receive either daunorubicin (50 mg/m(2) daily for 5 days) or idarubicin (12 mg/m(2) daily for 3 …
Quantitative Modeling and Simulation in PMDA: A Japanese Regulatory Perspective.
Sato M, Ochiai Y, Kijima S, Nagai N, Ando Y, Shikano M, Nomura Y. Sato M, et al. Among authors: nagai n. CPT Pharmacometrics Syst Pharmacol. 2017 Jul;6(7):413-415. doi: 10.1002/psp4.12203. Epub 2017 Jun 1. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 28568566 Free PMC article.
In this article, we summarize the number of submissions of quantitative modeling and simulation (M&S) documents in NDAs in Japan, and we describe our current thinking and activities about quantitative M&S in PMDA....
In this article, we summarize the number of submissions of quantitative modeling and simulation (M&S) documents in NDAs in Japan, …
M-PAST score is better than MAST score for the diagnosis of active fibrotic nonalcoholic steatohepatitis.
Imajo K, Saigusa Y, Kobayashi T, Nagai K, Nishida S, Kawamura N, Doi H, Iwaki M, Nogami A, Honda Y, Kessoku T, Ogawa Y, Kirikoshi H, Yasuda S, Toyoda H, Hayashi H, Kokubu S, Utsunomiya D, Takahashi H, Aishima S, Kim BK, Tamaki N, Saito S, Yoneda M, Loomba R, Nakajima A. Imajo K, et al. Among authors: nagai k. Hepatol Res. 2023 Sep;53(9):844-856. doi: 10.1111/hepr.13927. Epub 2023 Jun 15. Hepatol Res. 2023. PMID: 37237426 Free PMC article.
Following the rule-in criteria, positive predictive values of F-CAST (81.8%) and M-PAST (81.8%) were higher than those of FAST (73.5%) and MAST (70.0%). Following the rule-out criteria, negative predictive values of F-CAST (90.5%) and M-PAST (90.9%) were higher than …
Following the rule-in criteria, positive predictive values of F-CAST (81.8%) and M-PAST (81.8%) were higher than those of FAST (73.5% …
Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.
Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I. Abe H, et al. Among authors: nagai r. Nat Commun. 2019 Jun 27;10(1):2824. doi: 10.1038/s41467-019-10859-w. Nat Commun. 2019. PMID: 31249305 Free PMC article.
Here we show that macrophage hypoxia signaling suppresses excessive fibrosis in a heart via oncostatin-m (OSM) secretion. During cardiac remodeling, Ly6C(hi) monocytes/macrophages accumulate in hypoxic areas through a hypoxia-inducible factor (HIF)-1alpha dependent manner …
Here we show that macrophage hypoxia signaling suppresses excessive fibrosis in a heart via oncostatin-m (OSM) secretion. During card …
[Hemoglobin M disease].
Nagai M. Nagai M. Seikagaku. 1993 Sep;65(9):1160-4. Seikagaku. 1993. PMID: 8270817 Review. Japanese. No abstract available.
Heme-bound tyrosine vibrations in hemoglobin M: Resonance Raman, crystallography, and DFT calculation.
Nagatomo S, Shoji M, Terada T, Nakatani K, Shigeta Y, Hirota S, Yanagisawa S, Kubo M, Kitagawa T, Nagai M, Ohki M, Park SY, Shibayama N. Nagatomo S, et al. Among authors: nagai m. Biophys J. 2022 Jul 19;121(14):2767-2780. doi: 10.1016/j.bpj.2022.06.012. Epub 2022 Jun 9. Biophys J. 2022. PMID: 35689380 Free PMC article.
Hemoglobins M (Hbs M) are human hemoglobin variants in which either the alpha or beta subunit contains a ferric heme in the alpha(2)beta(2) tetramer. ...Based on the frequencies of the Raman bands, the Fe-O-C(Tyr) angles of Hbs M Iwate and M Boston wer …
Hemoglobins M (Hbs M) are human hemoglobin variants in which either the alpha or beta subunit contains a ferric heme in the al …
Color discrimination repetition distorts color representations.
Horiuchi S, Nagai T. Horiuchi S, et al. Among authors: nagai t. Sci Rep. 2024 Apr 26;14(1):9615. doi: 10.1038/s41598-024-60283-4. Sci Rep. 2024. PMID: 38671047 Free PMC article.
Participants performed five sessions of color discrimination training (200 or 300 trials per session) over five days, at colors on either the negative or positive direction of the L-M color axis, based on group assignment. We administered three color perception assessments …
Participants performed five sessions of color discrimination training (200 or 300 trials per session) over five days, at colors on either th …
Is surgical resection justified for pancreatic ductal adenocarcinoma with distant abdominal organ metastasis? A position paper by experts in pancreatic surgery at the Joint Meeting of the International Association of Pancreatology (IAP) & the Japan Pancreas Society (JPS) 2022 in Kyoto.
Hashimoto D, Satoi S, Fujii T, Sho M, He J, Hackert T, Del Chiaro M, Jang JY, Gulla A, Yoon YS, Shan YS, Lou W, Valente R, Furuse J, Oba A, Nagai M, Terai T, Tanaka H, Sakai A, Yamamoto T, Yamaki S, Matsumoto I, Murakami Y, Takaori K, Takeyama Y. Hashimoto D, et al. Among authors: nagai m. Pancreatology. 2023 Sep;23(6):682-688. doi: 10.1016/j.pan.2023.07.005. Epub 2023 Jul 20. Pancreatology. 2023. PMID: 37507301 Review.
An international consensus meeting on surgical treatment for UR-M PDAC was held during the Joint Congress of the 26th Meeting of the International Association of Pancreatology (IAP) and the 53rd Annual Meeting of the Japan Pancreas Society (JPS) in Kyoto in July 2022. The …
An international consensus meeting on surgical treatment for UR-M PDAC was held during the Joint Congress of the 26th Meeting of the …
1,711 results