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Year Number of Results
1969 1
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1980 6
1981 2
1982 4
1983 5
1984 4
1985 3
1986 6
1987 11
1988 6
1989 16
1990 19
1991 25
1992 31
1993 38
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1996 55
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1998 52
1999 74
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2002 136
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2004 194
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2007 297
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2009 414
2010 487
2011 564
2012 655
2013 777
2014 1041
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2017 1426
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2019 1920
2020 2237
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24,348 results

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Page 1
Absolute quantification of single-base m(6)A methylation in the mammalian transcriptome using GLORI.
Liu C, Sun H, Yi Y, Shen W, Li K, Xiao Y, Li F, Li Y, Hou Y, Lu B, Liu W, Meng H, Peng J, Yi C, Wang J. Liu C, et al. Among authors: sun h. Nat Biotechnol. 2023 Mar;41(3):355-366. doi: 10.1038/s41587-022-01487-9. Epub 2022 Oct 27. Nat Biotechnol. 2023. PMID: 36302990
Despite the development of various tools to map m(6)A, a transcriptome-wide method that enables absolute quantification of m(6)A at single-base resolution is lacking. ...In addition, we characterize m(6)A dynamics under stress and examine the quantitative lan …
Despite the development of various tools to map m(6)A, a transcriptome-wide method that enables absolute quantification of m(6 …
m(6)A modulates haematopoietic stem and progenitor cell specification.
Zhang C, Chen Y, Sun B, Wang L, Yang Y, Ma D, Lv J, Heng J, Ding Y, Xue Y, Lu X, Xiao W, Yang YG, Liu F. Zhang C, et al. Among authors: sun b. Nature. 2017 Sep 14;549(7671):273-276. doi: 10.1038/nature23883. Epub 2017 Sep 6. Nature. 2017. PMID: 28869969
Although the rapid development of high-throughput sequencing technologies has enabled insight into the biological functions of m(6)A modification, the function of m(6)A during vertebrate embryogenesis remains poorly understood. Here we show that m(6)A determi …
Although the rapid development of high-throughput sequencing technologies has enabled insight into the biological functions of m(6)A …
Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA.
Zhang LS, Liu C, Ma H, Dai Q, Sun HL, Luo G, Zhang Z, Zhang L, Hu L, Dong X, He C. Zhang LS, et al. Among authors: sun hl. Mol Cell. 2019 Jun 20;74(6):1304-1316.e8. doi: 10.1016/j.molcel.2019.03.036. Epub 2019 Apr 25. Mol Cell. 2019. PMID: 31031084 Free PMC article.
Here, we show the presence of internal m(7)G sites within mammalian mRNA. We then performed transcriptome-wide profiling of internal m(7)G methylome using m(7)G-MeRIP sequencing (MeRIP-seq). ...This base-resolution m(7)G-seq enabled transcriptome-wide …
Here, we show the presence of internal m(7)G sites within mammalian mRNA. We then performed transcriptome-wide profiling of internal …
Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors.
Song L, Gao S, Ye B, Yang M, Cheng Y, Kang D, Yi F, Sun JP, Menéndez-Arias L, Neyts J, Liu X, Zhan P. Song L, et al. Among authors: sun jp. Acta Pharm Sin B. 2024 Jan;14(1):87-109. doi: 10.1016/j.apsb.2023.08.004. Epub 2023 Aug 9. Acta Pharm Sin B. 2024. PMID: 38239241 Free PMC article. Review.
Numerous non-covalent M(pro) inhibitors with desirable properties have been developed based on available crystal structures of M(pro). ...Prospective viewpoints and insights into current strategies for the development of non-covalent M(pro) inhibitors are als …
Numerous non-covalent M(pro) inhibitors with desirable properties have been developed based on available crystal structures of M
Insights into the role of N6-methyladenosine in ferroptosis.
Zhang J, Qiu T, Yao X, Sun X. Zhang J, et al. Among authors: sun x. Biomed Pharmacother. 2023 Sep;165:115192. doi: 10.1016/j.biopha.2023.115192. Epub 2023 Jul 22. Biomed Pharmacother. 2023. PMID: 37487443 Free article. Review.
N6-methyladenosine (m(6)A) methylation modification is one of the most prevalent epigenetic modifications of eukaryotic RNA. m(6)A methylation is widely associated with many biological processes through the modification of RNA metabolism and is associated with multi …
N6-methyladenosine (m(6)A) methylation modification is one of the most prevalent epigenetic modifications of eukaryotic RNA. m
Exon-intron boundary inhibits m(6)A deposition, enabling m(6)A distribution hallmark, longer mRNA half-life and flexible protein coding.
Luo Z, Ma Q, Sun S, Li N, Wang H, Ying Z, Ke S. Luo Z, et al. Among authors: sun s. Nat Commun. 2023 Jul 13;14(1):4172. doi: 10.1038/s41467-023-39897-1. Nat Commun. 2023. PMID: 37443320 Free PMC article.
Regional bias of N(6)-methyladenosine (m(6)A) mRNA modification avoiding splice site region, calls for an open hypothesis whether exon-intron boundary could affect m(6)A deposition. ...Inhibited m(6)A sites have higher m(6)A enhancers and lower m
Regional bias of N(6)-methyladenosine (m(6)A) mRNA modification avoiding splice site region, calls for an open hypothesis whether exo …
m(6)Am RNA modification detection by m(6)Am-seq.
Zhang M, Sun H, Li K, Xiao Y, Yi C. Zhang M, et al. Among authors: sun h. Methods. 2022 Jul;203:242-248. doi: 10.1016/j.ymeth.2021.10.001. Epub 2021 Oct 6. Methods. 2022. PMID: 34624505
Here, we describe a specific and sensitive method, termed m(6)Am-seq, that can detect m(6)Am at single-base resolution. m(6)Am-seq is based on optimized in-vitro demethylation assay and RNA immunoprecipitation, which can distinguish m(6)Am from 5'-UTR …
Here, we describe a specific and sensitive method, termed m(6)Am-seq, that can detect m(6)Am at single-base resolution. m
m(6)A Editing: New Tool to Improve Crop Quality?
Zheng HX, Sun X, Zhang XS, Sui N. Zheng HX, et al. Among authors: sun x. Trends Plant Sci. 2020 Sep;25(9):859-867. doi: 10.1016/j.tplants.2020.04.005. Epub 2020 May 3. Trends Plant Sci. 2020. PMID: 32376086 Review.
However, changing m(6)A modification levels as a whole may have unpredictable effects, making it impossible to accurately predict the effect of specific m(6)A modifications on RNA. In this opinion article, the main challenges and possible solutions for exploring …
However, changing m(6)A modification levels as a whole may have unpredictable effects, making it impossible to accurately predict the …
Analysis approaches for the identification and prediction of N6-methyladenosine sites.
Yang Y, Liu Z, Lu J, Sun Y, Fu Y, Pan M, Xie X, Ge Q. Yang Y, et al. Among authors: sun y. Epigenetics. 2023 Dec;18(1):2158284. doi: 10.1080/15592294.2022.2158284. Epub 2022 Dec 23. Epigenetics. 2023. PMID: 36562485 Free PMC article. Review.
The global dynamics in a variety of biological processes can be revealed by mapping transcriptional m(6)A sites, in particular full-transcriptome m(6)A. And individual m(6)A sites have contributed to biological function, which can be evaluated by stoichiometr …
The global dynamics in a variety of biological processes can be revealed by mapping transcriptional m(6)A sites, in particular full-t …
N6-Methyladenosine in Cancer Immunotherapy: An Undervalued Therapeutic Target.
Quan C, Belaydi O, Hu J, Li H, Yu A, Liu P, Yi Z, Qiu D, Ren W, Ma H, Gong G, Ou Z, Chen M, Sun Y, Chen J, Zu X. Quan C, et al. Among authors: sun y. Front Immunol. 2021 Aug 30;12:697026. doi: 10.3389/fimmu.2021.697026. eCollection 2021. Front Immunol. 2021. PMID: 34526985 Free PMC article. Review.
In addition, m(6)A-targeting is found to affect the efficacy of classical immunotherapy, which makes m(6)A a potential target for immunotherapy. ...In this review, we discussed the link between m(6)A modification and tumor with an emphasis on the importance o …
In addition, m(6)A-targeting is found to affect the efficacy of classical immunotherapy, which makes m(6)A a potential target …
24,348 results
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