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The chimeric antigen receptor-intensive care unit (CAR-ICU) initiative: Surveying intensive care unit practices in the management of CAR T-cell associated toxicities.
Gutierrez C, Brown ART, Herr MM, Kadri SS, Hill B, Rajendram P, Duggal A, Turtle CJ, Patel K, Lin Y, May HP, Gallo de Moraes A, Maus MV, Frigault MJ, Brudno JN, Athale J, Shah NN, Kochenderfer JN, Dharshan A, Beitinjaneh A, Arias AS, McEvoy C, Mead E, Stephens RS, Nates JL, Neelapu SS, Pastores SM. Gutierrez C, et al. Among authors: brown art. J Crit Care. 2020 Aug;58:58-64. doi: 10.1016/j.jcrc.2020.04.008. Epub 2020 Apr 15. J Crit Care. 2020. PMID: 32361219 Free PMC article.
Critically Ill Patients Treated for Chimeric Antigen Receptor-Related Toxicity: A Multicenter Study.
Gutierrez C, Brown ART, May HP, Beitinjaneh A, Stephens RS, Rajendram P, Nates JL, Pastores SM, Dharshan A, de Moraes AG, Hensley MK, Feng L, Brudno JN, Athale J, Ghosh M, Kochenderfer JN, Arias AS, Lin Y, McEvoy C, Mead E, Westin J, Kostelecky N, Mian A, Herr MM. Gutierrez C, et al. Among authors: brown art. Crit Care Med. 2022 Jan 1;50(1):81-92. doi: 10.1097/CCM.0000000000005149. Crit Care Med. 2022. PMID: 34259446 Free PMC article.
Data Driven Computational Design and Experimental Validation of Drugs for Accelerated Mitigation of Pandemic-like Scenarios.
Singh SK, King K, Gannett C, Chuong C, Joshi SY, Plate C, Farzeen P, Webb EM, Kunche LK, Weger-Lucarelli J, Lowell AN, Brown AM, Deshmukh SA. Singh SK, et al. Among authors: brown am. J Phys Chem Lett. 2023 Oct 26;14(42):9490-9499. doi: 10.1021/acs.jpclett.3c01749. Epub 2023 Oct 18. J Phys Chem Lett. 2023. PMID: 37850349
Here, we present a data-driven computational framework composed of hybrid evolutionary algorithms for evolving functional groups on existing drugs to improve their binding affinity toward the main protease (M(pro)) of SARS-CoV-2. We show that combinations of functional gro …
Here, we present a data-driven computational framework composed of hybrid evolutionary algorithms for evolving functional groups on existing …
Purine salvage in Methanocaldococcus jannaschii: Elucidating the role of a conserved cysteine in adenine deaminase.
Miller DV, Brown AM, Xu H, Bevan DR, White RH. Miller DV, et al. Among authors: brown am. Proteins. 2016 Jun;84(6):828-40. doi: 10.1002/prot.25033. Epub 2016 Apr 1. Proteins. 2016. PMID: 26990095
Hpt demonstrated no detectable activity with adenine, but was equally specific for hypoxanthine and guanine with a kcat /KM of 3.2 10(7) and 3.0 10(7) s(- 1) M(- 1) , respectively. These results demonstrate that hypoxanthine and IMP are the central metabolites in purine sa …
Hpt demonstrated no detectable activity with adenine, but was equally specific for hypoxanthine and guanine with a kcat /KM of 3.2 10(7) and …
Does 1-minute walk test predict results of 6-minute walk test in patients with idiopathic pulmonary fibrosis?
Nunes FS, Pastre J, Brown AW, Shlobin OA, King C, Weir NA, Nathan SD. Nunes FS, et al. Among authors: brown aw. Sarcoidosis Vasc Diffuse Lung Dis. 2021;38(1):e2021005. doi: 10.36141/svdld.v38i1.9258. Epub 2021 Mar 31. Sarcoidosis Vasc Diffuse Lung Dis. 2021. PMID: 33867792 Free PMC article.
HW(6) had a higher FVC% (70 15 vs 57 18, p= 0.001), higher DLCO% (45 12 vs 34 14, p= 0.001) and higher 1MWD (83 28 vs 47 16, m p= 0.001). Median transplant-free survival was better in HW(6) vs LW(6) (27 16 vs 22 18 months, log rank p= 0.018). ...
HW(6) had a higher FVC% (70 15 vs 57 18, p= 0.001), higher DLCO% (45 12 vs 34 14, p= 0.001) and higher 1MWD (83 28 vs 47 16, m p= 0.0 …
Angiotensin converting enzyme-like activity in tissues from the river lamprey or lampern, Lampetra fluviatilis, acclimated to freshwater and seawater.
Cobb CS, Frankling SC, Rankin JC, Brown JA. Cobb CS, et al. Among authors: brown ja. Gen Comp Endocrinol. 2002 Jun 1;127(1):8-15. doi: 10.1016/s0016-6480(02)00014-x. Gen Comp Endocrinol. 2002. PMID: 12161196
Significant detection of ACELA was found in a wide range of lamprey tissues (brain, gill, gonad, gut, heart, liver, skeletal muscle, skin, kidney, and plasma). The mammalian ACE inhibitor captopril at 10(-5)M was an effective, but variable inhibitor of the ACELA found in m …
Significant detection of ACELA was found in a wide range of lamprey tissues (brain, gill, gonad, gut, heart, liver, skeletal muscle, skin, k …
Angiotensin I-converting enzyme-like activity in tissues from the Atlantic hagfish (Myxine glutinosa) and detection of immunoreactive plasma angiotensins.
Cobb CS, Frankling SC, Thorndyke MC, Jensen FB, Rankin JC, Brown JA. Cobb CS, et al. Among authors: brown ja. Comp Biochem Physiol B Biochem Mol Biol. 2004 Aug;138(4):357-64. doi: 10.1016/j.cbpc.2004.04.015. Comp Biochem Physiol B Biochem Mol Biol. 2004. PMID: 15325335
The mammalian angiotensin I-converting enzyme (ACE) inhibitor, captopril, at 10(-5) M was a potent inhibitor of the ACELA found in all hagfish tissues. ...
The mammalian angiotensin I-converting enzyme (ACE) inhibitor, captopril, at 10(-5) M was a potent inhibitor of the ACELA found in al …