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28 results

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Page 1
Rapid improvement of hepatic steatosis and liver stiffness after metabolic/bariatric surgery: a prospective study.
Nixdorf L, Hartl L, Ströhl S, Felsenreich DM, Mairinger M, Jedamzik J, Richwien P, Mozayani B, Semmler G, Balcar L, Schwarz M, Jachs M, Dominik N, Bichler C, Trauner M, Mandorfer M, Reiberger T, Langer FB, Bauer DJM, Prager G. Nixdorf L, et al. Among authors: bichler c. Sci Rep. 2024 Jul 30;14(1):17558. doi: 10.1038/s41598-024-67415-w. Sci Rep. 2024. PMID: 39080285 Free PMC article.
Liver stiffness measurement (LSM; via vibration-controlled transient elastography [VCTE], point [pSWE] and 2D [2DSWE] shear wave elastography) and non-invasive steatosis assessment (via controlled attenuation parameter [CAP]) were performed before (baseline [BL]) and three months …
Liver stiffness measurement (LSM; via vibration-controlled transient elastography [VCTE], point [pSWE] and 2D [2DSWE] shear wave elastograph …
Efficacy and safety of simoctocog alfa (Nuwiq®) in patients with severe hemophilia A: a review of clinical trial data from the GENA program.
Lissitchkov T, Klukowska A, Pasi J, Kessler CM, Klamroth R, Liesner RJ, Belyanskaya L, Walter O, Knaub S, Bichler J, Jansen M, Oldenburg J. Lissitchkov T, et al. Among authors: bichler j. Ther Adv Hematol. 2019 Jun 26;10:2040620719858471. doi: 10.1177/2040620719858471. eCollection 2019. Ther Adv Hematol. 2019. PMID: 31263528 Free PMC article. Review.
Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7.
Sun S, Chowdhury S, Hemeon I, Hasan A, Wilson MS, Bergeron P, Jia Q, Zenova AY, Grimwood ME, Gong W, Decker SM, Bichler P, Andrez JC, Focken T, Ngyuen T, Zhu J, White AD, Bankar G, Howard S, Chang E, Khakh K, Lin S, Dean R, Johnson JP Jr, Chang JH, Hackos DH, McKerrall SJ, Sellers B, Ortwine DF, Cohen CJ, Safina BS, Sutherlin DP, Dehnhardt CM. Sun S, et al. Among authors: bichler p. Bioorg Med Chem Lett. 2025 Feb 1;116:130033. doi: 10.1016/j.bmcl.2024.130033. Epub 2024 Nov 22. Bioorg Med Chem Lett. 2025. PMID: 39580005
The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism.
McGraw J, Cherney M, Bichler K, Gerhardt A, Nauman M. McGraw J, et al. Among authors: bichler k. Toxicol Lett. 2019 Oct 15;315:9-13. doi: 10.1016/j.toxlet.2019.08.003. Epub 2019 Aug 10. Toxicol Lett. 2019. PMID: 31408697
The 21-hydroxy metabolite is formed preferentially via CYP3A5 V(max)/K(M) (3.3) versus CYP3A4 V(max)/K(M) (1.9). Based on these findings, eplerenone has the potential to serve as an in-vivo substrate probe for CYP3A4 by monitoring 6-beta-hydroxy metabolite formation …
The 21-hydroxy metabolite is formed preferentially via CYP3A5 V(max)/K(M) (3.3) versus CYP3A4 V(max)/K(M) (1.9). Based on thes …
Endoluminal Vacuum Therapy as Effective Treatment for Patients with Postoperative Leakage After Metabolic Bariatric Surgery-A Single-Center Experience.
Gensthaler L, Stauffer M, Jedamzik J, Bichler C, Nixdorf L, Richwien P, Eichelter J, Langer FB, Prager G, Felsenreich DM. Gensthaler L, et al. Among authors: bichler c. Obes Surg. 2024 Sep;34(9):3306-3314. doi: 10.1007/s11695-024-07367-2. Epub 2024 Jul 24. Obes Surg. 2024. PMID: 39046624 Free PMC article.
Esophageal function and non-acid reflux evaluated by impedance-24 h-pH-metry, high-resolution manometry, and gastroscopy after one-anastomosis gastric bypass-outcomes of a prospective mid-term study.
Felsenreich DM, Zach ML, Vock N, Jedamzik J, Eichelter J, Mairinger M, Gensthaler L, Nixdorf L, Richwien P, Bichler C, Kristo I, Langer FB, Prager G. Felsenreich DM, et al. Among authors: bichler c. Surg Endosc. 2023 May;37(5):3832-3841. doi: 10.1007/s00464-022-09857-9. Epub 2023 Jan 24. Surg Endosc. 2023. PMID: 36693919 Free PMC article.
Preoperative weight was 124.4 17.3 kg with a BMI of 44.7 5.6 kg/m(2), total weight loss after 5.1 2.3 years was 34.4 8.3%. In addition, remission of AMP and QOL outcomes were very satisfactory in this study. ...
Preoperative weight was 124.4 17.3 kg with a BMI of 44.7 5.6 kg/m(2), total weight loss after 5.1 2.3 years was 34.4 8.3%. In additio …
Roux-en-Y Gastric Bypass as a Treatment for Barrett's Esophagus after Sleeve Gastrectomy.
Felsenreich DM, Langer FB, Bichler C, Eilenberg M, Jedamzik J, Kristo I, Vock N, Gensthaler L, Rabl C, Todoroff A, Prager G. Felsenreich DM, et al. Among authors: bichler c. Obes Surg. 2020 Apr;30(4):1273-1279. doi: 10.1007/s11695-019-04292-7. Obes Surg. 2020. PMID: 31808119
RESULTS: Weight and BMI at the time of SG was 120.8 kg and 45.1 kg/m(2). Eight patients (80.0%) went into remission of BE after the conversion to RYGB. ...
RESULTS: Weight and BMI at the time of SG was 120.8 kg and 45.1 kg/m(2). Eight patients (80.0%) went into remission of BE after the c …
Changes in Excitability Properties of Ventromedial Motor Thalamic Neurons in 6-OHDA Lesioned Mice.
Bichler EK, Cavarretta F, Jaeger D. Bichler EK, et al. eNeuro. 2021 Feb 24;8(1):ENEURO.0436-20.2021. doi: 10.1523/ENEURO.0436-20.2021. Print 2021 Jan-Feb. eNeuro. 2021. PMID: 33509950 Free PMC article.
At a minimum of one month after 6-OHDA treatment, BGMT neurons showed a highly significant increase in intrinsic excitability, which was primarily because of a decrease in M-type potassium current. BGMT neurons after 6-OHDA treatment also showed an increase in T-type calci …
At a minimum of one month after 6-OHDA treatment, BGMT neurons showed a highly significant increase in intrinsic excitability, which was pri …
Stapling Through a Bougie During Sleeve Gastrectomy in a Superobese Patient-a Video Vignette.
Bichler C, Jedamzik J, Felsenreich DM, Langer FB, Eilenberg M, Vock N, Steinlechner K, Eichelter J, Gensthaler L, Prager G. Bichler C, et al. Obes Surg. 2020 Oct;30(10):4167-4168. doi: 10.1007/s11695-020-04790-z. Epub 2020 Jul 2. Obes Surg. 2020. PMID: 32617922 Free PMC article.
PURPOSE: Bariatric-metabolic surgery in superobese patients (BMI > 50 kg/m(2)) is very challenging indeed with little room for error. In many cases, a two-step procedure is required, since more complex primary bariatric procedures can be technically demanding and bearin …
PURPOSE: Bariatric-metabolic surgery in superobese patients (BMI > 50 kg/m(2)) is very challenging indeed with little room for err …
28 results