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Year Number of Results
1962 1
1968 1
1969 5
1970 4
1971 3
1972 10
1974 10
1975 17
1976 6
1977 18
1978 9
1979 13
1980 14
1981 21
1982 21
1983 29
1984 36
1985 29
1986 38
1987 57
1988 60
1989 83
1990 91
1991 95
1992 149
1993 134
1994 185
1995 195
1996 208
1997 244
1998 245
1999 282
2000 319
2001 397
2002 408
2003 541
2004 580
2005 743
2006 899
2007 984
2008 1133
2009 1247
2010 1455
2011 1691
2012 1985
2013 2233
2014 2735
2015 3122
2016 3401
2017 3755
2018 4512
2019 5240
2020 6005
2021 7002
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2023 7955
2024 2953

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63,678 results

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Page 1
Epigenetic modification of m(6)A regulator proteins in cancer.
Wang Y, Wang Y, Patel H, Chen J, Wang J, Chen ZS, Wang H. Wang Y, et al. Among authors: chen j, chen zs. Mol Cancer. 2023 Jun 30;22(1):102. doi: 10.1186/s12943-023-01810-1. Mol Cancer. 2023. PMID: 37391814 Free PMC article. Review.
Divergent N(6)-methyladenosine (m(6)A) modifications are dynamic and reversible posttranscriptional RNA modifications that are mediated by m(6)A regulators or m(6)A RNA methylation regulators, i.e., methyltransferases ("writers"), demethylases ("erasers"), an …
Divergent N(6)-methyladenosine (m(6)A) modifications are dynamic and reversible posttranscriptional RNA modifications that are mediat …
Differential m(6)A, m(6)A(m), and m(1)A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.
Wei J, Liu F, Lu Z, Fei Q, Ai Y, He PC, Shi H, Cui X, Su R, Klungland A, Jia G, Chen J, He C. Wei J, et al. Among authors: chen j. Mol Cell. 2018 Sep 20;71(6):973-985.e5. doi: 10.1016/j.molcel.2018.08.011. Epub 2018 Sep 6. Mol Cell. 2018. PMID: 30197295 Free PMC article.
We find that FTO binds multiple RNA species, including mRNA, snRNA, and tRNA, and can demethylate internal m(6)A and cap m(6)A(m) in mRNA, internal m(6)A in U6 RNA, internal and cap m(6)A(m) in snRNAs, and N(1)-methyladenosine (m(1 …
We find that FTO binds multiple RNA species, including mRNA, snRNA, and tRNA, and can demethylate internal m(6)A and cap m(6)A …
m(6)A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3.
Shan T, Liu F, Wen M, Chen Z, Li S, Wang Y, Cheng H, Zhou Y. Shan T, et al. Among authors: chen z. Mol Cell. 2023 Dec 21;83(24):4494-4508.e6. doi: 10.1016/j.molcel.2023.10.040. Epub 2023 Nov 27. Mol Cell. 2023. PMID: 38016476
By quantifying the m(6)A level of polysomal and cytoplasmic mRNAs with m(6)A-LAIC-seq and m(6)A-LC-MS/MS in HeLa cells, we observed that polysome-associated mRNAs are hypo-m(6)A-methylated, whereas those enriched in P-body are hyper-m(6)A-methyl …
By quantifying the m(6)A level of polysomal and cytoplasmic mRNAs with m(6)A-LAIC-seq and m(6)A-LC-MS/MS in HeLa cells, …
Reversible methylation of m(6)A(m) in the 5' cap controls mRNA stability.
Mauer J, Luo X, Blanjoie A, Jiao X, Grozhik AV, Patil DP, Linder B, Pickering BF, Vasseur JJ, Chen Q, Gross SS, Elemento O, Debart F, Kiledjian M, Jaffrey SR. Mauer J, et al. Among authors: chen q. Nature. 2017 Jan 19;541(7637):371-375. doi: 10.1038/nature21022. Epub 2016 Dec 21. Nature. 2017. PMID: 28002401 Free PMC article.
Using a transcriptome-wide map of m(6)A(m) we find that m(6)A(m)-initiated transcripts are markedly more stable than mRNAs that begin with other nucleotides. ...FTO preferentially demethylates m(6)A(m) rather than N(6)-methyladenosine ( …
Using a transcriptome-wide map of m(6)A(m) we find that m(6)A(m)-initiated transcripts are markedly more stable …
CAR-Macrophages and CAR-T Cells Synergistically Kill Tumor Cells In Vitro.
Liu M, Liu J, Liang Z, Dai K, Gan J, Wang Q, Xu Y, Chen YH, Wan X. Liu M, et al. Among authors: chen yh. Cells. 2022 Nov 21;11(22):3692. doi: 10.3390/cells11223692. Cells. 2022. PMID: 36429120 Free PMC article.
We found that CAR-M(FcRgamma) exerted more potent phagocytic and tumor-killing capacity than CAR-M(Megf10) and CAR-M(PI3K). CAR-M and CAR-T demonstrated synergistic cytotoxicity against tumor cells in vitro. ...
We found that CAR-M(FcRgamma) exerted more potent phagocytic and tumor-killing capacity than CAR-M(Megf10) and CAR-M(PI …
TROP2 translation mediated by dual m(6)A/m(7)G RNA modifications promotes bladder cancer development.
Chen C, Chao Y, Zhang C, Hu W, Huang Y, Lv Y, Liu B, Ji D, Liu M, Yang B, Jiang L, Liang Y, Zhang H, Yuan G, Ying X, Ji W. Chen C, et al. Cancer Lett. 2023 Jul 10;566:216246. doi: 10.1016/j.canlet.2023.216246. Epub 2023 Jun 1. Cancer Lett. 2023. PMID: 37268280
RNA modifications, including adenine methylation (m(6)A) of mRNA and guanine methylation (m(7)G) of tRNA, are crucial for the biological function of RNA. ...We demonstrated that m(6)A methyltransferase METTL3-mediated programmable m(6)A modification of …
RNA modifications, including adenine methylation (m(6)A) of mRNA and guanine methylation (m(7)G) of tRNA, are crucial for the …
Detection, regulation, and functions of RNA N6-methyladenosine modification in plants.
Tang J, Chen S, Jia G. Tang J, et al. Among authors: chen s. Plant Commun. 2023 May 8;4(3):100546. doi: 10.1016/j.xplc.2023.100546. Epub 2023 Jan 10. Plant Commun. 2023. PMID: 36627844 Free PMC article. Review.
Recently, the breadth of research on m(6)A in plants has expanded, and the vital roles of m(6)A in plant development, biotic and abiotic stress responses, and crop trait improvement have been investigated. In this review, we discuss recent developments in research o …
Recently, the breadth of research on m(6)A in plants has expanded, and the vital roles of m(6)A in plant development, biotic a …
Emerging roles of biological m(6)A proteins in regulating virus infection: A review.
Chen Y, Wang W, Zhang W, He M, Li Y, Qu G, Tong J. Chen Y, et al. Int J Biol Macromol. 2023 Dec 31;253(Pt 3):126934. doi: 10.1016/j.ijbiomac.2023.126934. Epub 2023 Sep 16. Int J Biol Macromol. 2023. PMID: 37722640 Review.
As a dynamic process, three groups of biological proteins control the levels of m(6)A modification in eukaryocyte, designed as m(6)A writers, erasers, and readers. ...The known m(6)A readers include the YTH family and the hnRNP family. As m(6)A modific …
As a dynamic process, three groups of biological proteins control the levels of m(6)A modification in eukaryocyte, designed as m …
Immune Evasion of Mycoplasma bovis.
Askar H, Chen S, Hao H, Yan X, Ma L, Liu Y, Chu Y. Askar H, et al. Among authors: chen s. Pathogens. 2021 Mar 4;10(3):297. doi: 10.3390/pathogens10030297. Pathogens. 2021. PMID: 33806506 Free PMC article. Review.
This consists of an inflammatory response in the host that causes pathological immune damage, which is essential for the pathogenic mechanism of M. bovis. Additionally, M. bovis can escape host immune system elimination and, thus, cause chronic infection. ...This re …
This consists of an inflammatory response in the host that causes pathological immune damage, which is essential for the pathogenic mechanis …
Mapping single-nucleotide m(6)A by m(6)A-REF-seq.
Chen HX, Zhang Z, Ma DZ, Chen LQ, Luo GZ. Chen HX, et al. Among authors: chen lq. Methods. 2022 Jul;203:392-398. doi: 10.1016/j.ymeth.2021.06.013. Epub 2021 Jun 24. Methods. 2022. PMID: 34174388
However, limitations of the detection method impede functional studies of m(6)A. Here we introduce m(6)A-REF-seq, a powerful and straightforward method to identify m(6)A at single-nucleotide resolution. m(6)A-REF-seq relies on the recognition of RNA en …
However, limitations of the detection method impede functional studies of m(6)A. Here we introduce m(6)A-REF-seq, a powerful a …
63,678 results
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