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223 results

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Page 1
Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis.
D'Haens G, Dubinsky M, Kobayashi T, Irving PM, Howaldt S, Pokrotnieks J, Krueger K, Laskowski J, Li X, Lissoos T, Milata J, Morris N, Arora V, Milch C, Sandborn W, Sands BE; LUCENT Study Group. D'Haens G, et al. N Engl J Med. 2023 Jun 29;388(26):2444-2455. doi: 10.1056/NEJMoa2207940. N Engl J Med. 2023. PMID: 37379135 Clinical Trial.
Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis.
Sands BE, Feagan BG, Peyrin-Biroulet L, Danese S, Rubin DT, Laurent O, Luo A, Nguyen DD, Lu J, Yen M, Leszczyszyn J, Kempiński R, McGovern DPB, Ma C, Ritter TE, Targan S; ARTEMIS-UC Study Group. Sands BE, et al. N Engl J Med. 2024 Sep 26;391(12):1119-1129. doi: 10.1056/NEJMoa2314076. N Engl J Med. 2024. PMID: 39321363 Clinical Trial.
Radiation-induced bone loss in mice is ameliorated by inhibition of HIF-2α in skeletal progenitor cells.
Guo W, Hoque J, Garcia Garcia CJ, Spiller KV, Leinroth AP, Puviindran V, Potnis CK, Gunn KA, Newman H, Ishikawa K, Fujimoto TN, Neill DW, Delahoussaye AM, Williams NT, Kirsch DG, Hilton MJ, Varghese S, Taniguchi CM, Wu C. Guo W, et al. Sci Transl Med. 2023 Nov 29;15(724):eabo5217. doi: 10.1126/scitranslmed.abo5217. Epub 2023 Nov 29. Sci Transl Med. 2023. PMID: 38019933 Free PMC article.
Cytotoxicity of apo bovine α-lactalbumin complexed with La3+ on cancer cells supported by its high resolution crystal structure.
Yarramala DS, Prakash P, Ranade DS, Doshi S, Kulkarni PP, Bhaumik P, Rao CP. Yarramala DS, et al. Sci Rep. 2019 Feb 11;9(1):1780. doi: 10.1038/s41598-018-38024-1. Sci Rep. 2019. PMID: 30741951 Free PMC article.
Earlier studies have shown that bovine alpha -lactalbumin made lethal to tumor cells (BAMLET) becomes cytotoxic against cancer cells in complex with oleic acid {Hoque, M. et. al., PLoSOne 8, e68390 (2013)}. In our study, we obtained bovine alpha-lactalbumin complexe …
Earlier studies have shown that bovine alpha -lactalbumin made lethal to tumor cells (BAMLET) becomes cytotoxic against cancer cells in comp …
Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability.
Maurice D, Pierreux CE, Howell M, Wilentz RE, Owen MJ, Hill CS. Maurice D, et al. J Biol Chem. 2001 Nov 16;276(46):43175-81. doi: 10.1074/jbc.M105895200. Epub 2001 Sep 11. J Biol Chem. 2001. PMID: 11553622 Free article.
A nonsense mutation generating a C-terminal truncation of 38 amino acids in the Smad4 protein has been identified in a pancreatic adenocarcinoma (Hahn, S. A., Schutte, M., Hoque, A. T., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., …
A nonsense mutation generating a C-terminal truncation of 38 amino acids in the Smad4 protein has been identified in a pancreatic adenocarci …
223 results