Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 1
1977 1
1980 1
1981 1
1983 1
1984 2
1985 2
1986 1
1987 1
1988 1
1989 2
1990 1
1991 1
1992 3
1993 3
1994 5
1995 6
1996 10
1997 14
1998 12
1999 22
2000 22
2001 27
2002 27
2003 29
2004 28
2005 35
2006 29
2007 32
2008 35
2009 25
2010 24
2011 27
2012 32
2013 21
2014 28
2015 32
2016 18
2017 18
2018 20
2019 23
2020 19
2021 13
2022 12
Text availability
Article attribute
Article type
Publication date

Search Results

625 results
Results by year
Filters applied: . Clear all
Page 1
MAD1: Kinetochore Receptors and Catalytic Mechanisms.
Luo Y, Ahmad E, Liu ST. Luo Y, et al. Front Cell Dev Biol. 2018 May 7;6:51. doi: 10.3389/fcell.2018.00051. eCollection 2018. Front Cell Dev Biol. 2018. PMID: 29868582 Free PMC article. Review.
The mitotic checkpoint monitors kinetochore-microtubule attachment, delays anaphase onset and prevents aneuploidy when unattached or tensionless kinetochores are present in cells. Mitotic arrest deficiency 1 (MAD1) is one of the evolutionarily conserved core mitotic checkp …
The mitotic checkpoint monitors kinetochore-microtubule attachment, delays anaphase onset and prevents aneuploidy when unattached or tension …
MAD1 and its life as a MYC antagonist: an update.
Lüscher B. Lüscher B. Eur J Cell Biol. 2012 Jun-Jul;91(6-7):506-14. doi: 10.1016/j.ejcb.2011.07.005. Epub 2011 Sep 13. Eur J Cell Biol. 2012. PMID: 21917351 Review.
Thus these proteins function as a molecular switch to control gene expression. MAD1, a member of this network, acts as a transcriptional repressor. ...In addition recent evidence indicates that the expression and activity of MAD1 are regulated at multiple levels. He …
Thus these proteins function as a molecular switch to control gene expression. MAD1, a member of this network, acts as a transcriptio …
Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1.
Fischer ES, Yu CWH, Bellini D, McLaughlin SH, Orr CM, Wagner A, Freund SMV, Barford D. Fischer ES, et al. EMBO Rep. 2021 Jul 5;22(7):e52242. doi: 10.15252/embr.202052242. Epub 2021 May 19. EMBO Rep. 2021. PMID: 34013668 Free PMC article.
Here, we present the crystal structure of the C-terminal domain of Mad1 (Mad1(CTD) ) bound to two phosphorylated Bub1(CD1) peptides at 1.75 A resolution. ...Surprisingly, only one Bub1(CD1) peptide binds to the Mad1 homodimer in solution. We suggest that this …
Here, we present the crystal structure of the C-terminal domain of Mad1 (Mad1(CTD) ) bound to two phosphorylated Bub1(CD1) pep …
The Mad1-Mad2 balancing act--a damaged spindle checkpoint in chromosome instability and cancer.
Schuyler SC, Wu YF, Kuan VJ. Schuyler SC, et al. J Cell Sci. 2012 Sep 15;125(Pt 18):4197-206. doi: 10.1242/jcs.107037. Epub 2012 Oct 23. J Cell Sci. 2012. PMID: 23093575 Review.
One form of damage is a change in levels of the checkpoint proteins mitotic arrest deficient 1 and 2 (Mad1 and Mad2), or in the Mad1:Mad2 ratio. Changes in Mad1 and Mad2 levels occur in human cancers, where their expression is regulated by the tumor suppresso …
One form of damage is a change in levels of the checkpoint proteins mitotic arrest deficient 1 and 2 (Mad1 and Mad2), or in the Ma
Mad1 destabilizes p53 by preventing PML from sequestering MDM2.
Wan J, Block S, Scribano CM, Thiry R, Esbona K, Audhya A, Weaver BA. Wan J, et al. Nat Commun. 2019 Apr 4;10(1):1540. doi: 10.1038/s41467-019-09471-9. Nat Commun. 2019. PMID: 30948704 Free PMC article.
Mitotic arrest deficient 1 (Mad1) plays a well-characterized role in the mitotic checkpoint. ...The C-terminus of Mad1 directly interacts with PML, and this interaction is enhanced by sumoylation. ...
Mitotic arrest deficient 1 (Mad1) plays a well-characterized role in the mitotic checkpoint. ...The C-terminus of Mad1 directl …
Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans.
Devigne A, Bhalla N. Devigne A, et al. PLoS Genet. 2021 Nov 11;17(11):e1009598. doi: 10.1371/journal.pgen.1009598. eCollection 2021 Nov. PLoS Genet. 2021. PMID: 34762652 Free PMC article.
Here, we test what specific functions of Mad1 and Mad2 are required to regulate and monitor synapsis. We find that a mutation that prevents Mad1's localization to the nuclear periphery abolishes the synapsis checkpoint but has no effect on Mad2's localization to the …
Here, we test what specific functions of Mad1 and Mad2 are required to regulate and monitor synapsis. We find that a mutation that pr …
Aneuploid abortion correlates positively with MAD1 overexpression and miR-125b down-regulation.
Zhao J, Li H, Chen G, Du L, Xu P, Zhang X, Xie M, Cao T, Li H. Zhao J, et al. Mol Cytogenet. 2021 Apr 26;14(1):22. doi: 10.1186/s13039-021-00538-1. Mol Cytogenet. 2021. PMID: 33902659 Free PMC article.
Studies have confirmed that overexpression of MAD2 and BUBR1 can facilitate correct chromosome segregation and embryo stability. Research also proves that miR-125b negatively regulates MAD1 expression by binding to its 3'UTR. However, miR-125b, Mad1 and Bub3 gene ex …
Studies have confirmed that overexpression of MAD2 and BUBR1 can facilitate correct chromosome segregation and embryo stability. Research al …
Mad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila.
Raich N, Mahmoudi S, Emre D, Karess RE. Raich N, et al. Open Biol. 2018 Oct 17;8(10):180166. doi: 10.1098/rsob.180166. Open Biol. 2018. PMID: 30333236 Free PMC article.
The Drosophila Mad1 spindle checkpoint protein helps organize several nucleoplasmic components, and flies lacking Mad1 present changes in gene expression reflecting altered chromatin conformation. ...Whether Mad1 has other nuclear interphase functions is unkn …
The Drosophila Mad1 spindle checkpoint protein helps organize several nucleoplasmic components, and flies lacking Mad1 present …
Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint.
Allan LA, Camacho Reis M, Ciossani G, Huis In 't Veld PJ, Wohlgemuth S, Kops GJ, Musacchio A, Saurin AT. Allan LA, et al. EMBO J. 2020 Jun 17;39(12):e103180. doi: 10.15252/embj.2019103180. Epub 2020 Mar 23. EMBO J. 2020. PMID: 32202322 Free PMC article.
Therefore, Cyclin B1 is the long-sought-after scaffold that links MAD1 to the corona, and this specific pool of MAD1 is needed to generate a robust SAC response. Robustness arises because Cyclin B1:MAD1 localisation loses dependence on MPS1 kinase after the c …
Therefore, Cyclin B1 is the long-sought-after scaffold that links MAD1 to the corona, and this specific pool of MAD1 is needed …
Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation.
Cunha-Silva S, Osswald M, Goemann J, Barbosa J, Santos LM, Resende P, Bange T, Ferrás C, Sunkel CE, Conde C. Cunha-Silva S, et al. J Cell Biol. 2020 Mar 2;219(3):e201906039. doi: 10.1083/jcb.201906039. J Cell Biol. 2020. PMID: 31913420 Free PMC article.
However, the molecular underpinnings controlling the spatiotemporal redistribution of Mad1-C-Mad2 as cells progress into mitosis remain elusive. Here, we show that activation of Mps1 during prophase triggers Mad1 release from NPCs and that this is required for kinet …
However, the molecular underpinnings controlling the spatiotemporal redistribution of Mad1-C-Mad2 as cells progress into mitosis rema …
625 results