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Table representation of search results timeline featuring number of search results per year.

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1987 1
1988 1
1989 2
1990 1
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1992 3
1993 3
1994 5
1995 6
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2002 27
2003 29
2004 28
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2024 8

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650 results

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Page 1
MAD1: Kinetochore Receptors and Catalytic Mechanisms.
Luo Y, Ahmad E, Liu ST. Luo Y, et al. Front Cell Dev Biol. 2018 May 7;6:51. doi: 10.3389/fcell.2018.00051. eCollection 2018. Front Cell Dev Biol. 2018. PMID: 29868582 Free PMC article. Review.
The mitotic checkpoint monitors kinetochore-microtubule attachment, delays anaphase onset and prevents aneuploidy when unattached or tensionless kinetochores are present in cells. Mitotic arrest deficiency 1 (MAD1) is one of the evolutionarily conserved core mitotic checkp …
The mitotic checkpoint monitors kinetochore-microtubule attachment, delays anaphase onset and prevents aneuploidy when unattached or tension …
MAD1 and its life as a MYC antagonist: an update.
Lüscher B. Lüscher B. Eur J Cell Biol. 2012 Jun-Jul;91(6-7):506-14. doi: 10.1016/j.ejcb.2011.07.005. Epub 2011 Sep 13. Eur J Cell Biol. 2012. PMID: 21917351 Review.
Thus these proteins function as a molecular switch to control gene expression. MAD1, a member of this network, acts as a transcriptional repressor. ...In addition recent evidence indicates that the expression and activity of MAD1 are regulated at multiple levels. He …
Thus these proteins function as a molecular switch to control gene expression. MAD1, a member of this network, acts as a transcriptio …
Mad1 destabilizes p53 by preventing PML from sequestering MDM2.
Wan J, Block S, Scribano CM, Thiry R, Esbona K, Audhya A, Weaver BA. Wan J, et al. Nat Commun. 2019 Apr 4;10(1):1540. doi: 10.1038/s41467-019-09471-9. Nat Commun. 2019. PMID: 30948704 Free PMC article.
Mitotic arrest deficient 1 (Mad1) plays a well-characterized role in the mitotic checkpoint. ...The C-terminus of Mad1 directly interacts with PML, and this interaction is enhanced by sumoylation. ...
Mitotic arrest deficient 1 (Mad1) plays a well-characterized role in the mitotic checkpoint. ...The C-terminus of Mad1 directl …
The Mad1-Mad2 balancing act--a damaged spindle checkpoint in chromosome instability and cancer.
Schuyler SC, Wu YF, Kuan VJ. Schuyler SC, et al. J Cell Sci. 2012 Sep 15;125(Pt 18):4197-206. doi: 10.1242/jcs.107037. Epub 2012 Oct 23. J Cell Sci. 2012. PMID: 23093575 Review.
One form of damage is a change in levels of the checkpoint proteins mitotic arrest deficient 1 and 2 (Mad1 and Mad2), or in the Mad1:Mad2 ratio. Changes in Mad1 and Mad2 levels occur in human cancers, where their expression is regulated by the tumor suppresso …
One form of damage is a change in levels of the checkpoint proteins mitotic arrest deficient 1 and 2 (Mad1 and Mad2), or in the Ma
Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1.
Fischer ES, Yu CWH, Bellini D, McLaughlin SH, Orr CM, Wagner A, Freund SMV, Barford D. Fischer ES, et al. EMBO Rep. 2021 Jul 5;22(7):e52242. doi: 10.15252/embr.202052242. Epub 2021 May 19. EMBO Rep. 2021. PMID: 34013668 Free PMC article.
Here, we present the crystal structure of the C-terminal domain of Mad1 (Mad1(CTD) ) bound to two phosphorylated Bub1(CD1) peptides at 1.75 A resolution. ...Surprisingly, only one Bub1(CD1) peptide binds to the Mad1 homodimer in solution. We suggest that this …
Here, we present the crystal structure of the C-terminal domain of Mad1 (Mad1(CTD) ) bound to two phosphorylated Bub1(CD1) pep …
Mad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila.
Raich N, Mahmoudi S, Emre D, Karess RE. Raich N, et al. Open Biol. 2018 Oct 17;8(10):180166. doi: 10.1098/rsob.180166. Open Biol. 2018. PMID: 30333236 Free PMC article.
The Drosophila Mad1 spindle checkpoint protein helps organize several nucleoplasmic components, and flies lacking Mad1 present changes in gene expression reflecting altered chromatin conformation. ...Whether Mad1 has other nuclear interphase functions is unkn …
The Drosophila Mad1 spindle checkpoint protein helps organize several nucleoplasmic components, and flies lacking Mad1 present …
The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex.
Chen C, Piano V, Alex A, Han SJY, Huis In 't Veld PJ, Roy B, Fergle D, Musacchio A, Joglekar AP. Chen C, et al. Nat Commun. 2023 Mar 18;14(1):1529. doi: 10.1038/s41467-023-37235-z. Nat Commun. 2023. PMID: 36934097 Free PMC article.
Here, we demonstrate that the structural flexibility of MAD1 at a conserved hinge near the C-terminus is essential for catalytic MCC assembly. This MAD1 hinge enables the MAD1:MAD2 complex to assume a folded conformation in vivo. ...
Here, we demonstrate that the structural flexibility of MAD1 at a conserved hinge near the C-terminus is essential for catalytic MCC …
ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint.
Yuan F, Jin X, Li D, Song Y, Zhang N, Yang X, Wang L, Zhu WG, Tian C, Zhao Y. Yuan F, et al. Nucleic Acids Res. 2019 Sep 5;47(15):8096-8110. doi: 10.1093/nar/gkz602. Nucleic Acids Res. 2019. PMID: 31291454 Free PMC article.
Here, we show that ULK1, a serine/threonine kinase that plays a key role in initiation of autophagy, also has an important function in the activation of SAC. ULK1 phosphorylates the SAC protein Mad1 at Ser546 to recruit Mad1 to kinetochores. Furthermore, Rod/ZW10/Zw …
Here, we show that ULK1, a serine/threonine kinase that plays a key role in initiation of autophagy, also has an important function in the a …
MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling.
Alfonso-Pérez T, Hayward D, Holder J, Gruneberg U, Barr FA. Alfonso-Pérez T, et al. J Cell Biol. 2019 Apr 1;218(4):1108-1117. doi: 10.1083/jcb.201808015. Epub 2019 Jan 23. J Cell Biol. 2019. PMID: 30674583 Free PMC article.
Complementary proteomic and cell biological analysis demonstrate that the spindle checkpoint protein MAD1 is one of the major components of CCNB1 complexes, and that CCNB1 is recruited to unattached kinetochores in an MPS1-dependent fashion through interaction with the fir …
Complementary proteomic and cell biological analysis demonstrate that the spindle checkpoint protein MAD1 is one of the major compone …
Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans.
Devigne A, Bhalla N. Devigne A, et al. PLoS Genet. 2021 Nov 11;17(11):e1009598. doi: 10.1371/journal.pgen.1009598. eCollection 2021 Nov. PLoS Genet. 2021. PMID: 34762652 Free PMC article.
Here, we test what specific functions of Mad1 and Mad2 are required to regulate and monitor synapsis. We find that a mutation that prevents Mad1's localization to the nuclear periphery abolishes the synapsis checkpoint but has no effect on Mad2's localization to the …
Here, we test what specific functions of Mad1 and Mad2 are required to regulate and monitor synapsis. We find that a mutation that pr …
650 results