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MALSU1-mediated regulation of mitochondrial function governs proliferation and doxorubicin resistance in triple-negative breast cancer cells.
Zhuang F, Huang S, Liu L. Zhuang F, et al. Mol Cell Biochem. 2025 Feb;480(2):1197-1207. doi: 10.1007/s11010-024-05053-6. Epub 2024 Jun 19. Mol Cell Biochem. 2025. PMID: 38896203
We observed increased MALSU1 expression in TNBC, correlating with poor patient prognosis. MALSU1 knockdown in TNBC cells significantly reduced proliferation, indicating its pivotal role in sustaining cell growth. ...Notably, exogenous addition of normal mitochondria …
We observed increased MALSU1 expression in TNBC, correlating with poor patient prognosis. MALSU1 knockdown in TNBC cells signi …
Ortholog of autism candidate gene RBM27 regulates mitoribosomal assembly factor MALS-1 to protect against mitochondrial dysfunction and axon degeneration during neurodevelopment.
Chowdhury TA, Luy DA, Scapellato G, Farache D, Lee ASY, Quinn CC. Chowdhury TA, et al. PLoS Biol. 2024 Oct 31;22(10):e3002876. doi: 10.1371/journal.pbio.3002876. eCollection 2024 Oct. PLoS Biol. 2024. PMID: 39480871 Free PMC article.
We report that RBM-26 (RBM26/27) protects against axonal defects by negatively regulating expression of the MALS-1 (MALSU1) mitoribosomal assembly factor. Autism-associated missense variants in RBM-26 cause a sharp decrease in RBM-26 protein expression along with defects i …
We report that RBM-26 (RBM26/27) protects against axonal defects by negatively regulating expression of the MALS-1 (MALSU1) mitoribos …
Identification and validation of a prognostic model based on ferroptosis-associated genes in head and neck squamous cancer.
Wei M, Tian Y, Lv Y, Liu G, Cai G. Wei M, et al. Front Genet. 2022 Dec 1;13:1065546. doi: 10.3389/fgene.2022.1065546. eCollection 2022. Front Genet. 2022. PMID: 36531250 Free PMC article.
After using lasso regression, we identified 8 genes (ZNF566, ZNF541, TMEM150C, PPAN, PGLYRP4, ENDOU, RPL23 and MALSU1) as ferroptosis-related genes affecting prognosis. The ferroptosis prognosis-related risk score (FPRS) was calculated for each sample in TCGA-HNSC dataset. …
After using lasso regression, we identified 8 genes (ZNF566, ZNF541, TMEM150C, PPAN, PGLYRP4, ENDOU, RPL23 and MALSU1) as ferroptosis …
Tetracyclines activate mitoribosome quality control and reduce ER stress to promote cell survival.
Ronayne CT, Jackson TD, Bennett CF, Perry EA, Kantorovic N, Puigserver P. Ronayne CT, et al. EMBO Rep. 2023 Dec 6;24(12):e57228. doi: 10.15252/embr.202357228. Epub 2023 Oct 11. EMBO Rep. 2023. PMID: 37818824 Free PMC article.
Tetracyclines increase mitochondrial levels of the mitoribosome quality control factor MALSU1 (Mitochondrial Assembly of Ribosomal Large Subunit 1) and promote its recruitment to the mitoribosome large subunit, where MALSU1 is necessary for tetracycline-induced surv …
Tetracyclines increase mitochondrial levels of the mitoribosome quality control factor MALSU1 (Mitochondrial Assembly of Ribosomal La …
Single-cell RNA sequencing identifies macrophage signatures correlated with clinical features and tumour microenvironment in meningiomas.
Zhang X. Zhang X. IET Syst Biol. 2023 Oct;17(5):259-270. doi: 10.1049/syb2.12074. Epub 2023 Jul 29. IET Syst Biol. 2023. PMID: 37515398 Free PMC article.
Machine learning analysis identified 13 module genes (RSBN1, TIPRL, ATIC, SPP1, MALSU1, CDK1, MGP, DDIT3, SUPT16H, NFKBIA, SRSF5, ATXN2L, and UBB) strongly correlated with meningioma grade and constructed a predictive model with high accuracy and robustness. ...
Machine learning analysis identified 13 module genes (RSBN1, TIPRL, ATIC, SPP1, MALSU1, CDK1, MGP, DDIT3, SUPT16H, NFKBIA, SRSF5, ATX …
Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly.
Cipullo M, Pearce SF, Lopez Sanchez IG, Gopalakrishna S, Krüger A, Schober F, Busch JD, Li X, Wredenberg A, Atanassov I, Rorbach J. Cipullo M, et al. Nucleic Acids Res. 2021 Jan 11;49(1):354-370. doi: 10.1093/nar/gkaa1131. Nucleic Acids Res. 2021. PMID: 33283228 Free PMC article.
We show that GTPBP5 interacts specifically with the large mitoribosomal subunit (mt-LSU) proteins and several late-stage mitoribosome assembly factors, including MTERF4:NSUN4 complex, MRM2 methyltransferase, MALSU1 and MTG1. Interestingly, we find that interaction of GTPBP …
We show that GTPBP5 interacts specifically with the large mitoribosomal subunit (mt-LSU) proteins and several late-stage mitoribosome assemb …
A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
Rebelo-Guiomar P, Pellegrino S, Dent KC, Sas-Chen A, Miller-Fleming L, Garone C, Van Haute L, Rogan JF, Dinan A, Firth AE, Andrews B, Whitworth AJ, Schwartz S, Warren AJ, Minczuk M. Rebelo-Guiomar P, et al. Nat Commun. 2022 Feb 17;13(1):929. doi: 10.1038/s41467-022-28503-5. Nat Commun. 2022. PMID: 35177605 Free PMC article.
In its absence, mtLSU particles (visualized by cryo-EM at the resolution of 2.6 A) present disordered RNA domains, partial occupancy of bL36m and bound MALSU1:L0R8F8:mtACP anti-association module, allowing five mtLSU biogenesis intermediates with different intersubunit int …
In its absence, mtLSU particles (visualized by cryo-EM at the resolution of 2.6 A) present disordered RNA domains, partial occupancy of bL36 …
Autism candidate gene rbm-26 (RBM26/27) regulates MALS-1 to protect against mitochondrial dysfunction and axon degeneration during neurodevelopment.
Chowdhury TA, Luy DA, Scapellato G, Farache D, Lee AS, Quinn CC. Chowdhury TA, et al. bioRxiv [Preprint]. 2024 Sep 25:2023.10.12.562060. doi: 10.1101/2023.10.12.562060. bioRxiv. 2024. Update in: PLoS Biol. 2024 Oct 31;22(10):e3002876. doi: 10.1371/journal.pbio.3002876. PMID: 37873356 Free PMC article. Updated. Preprint.
We report that RBM-26 (RBM26/27) protects against axonal defects by negatively regulating expression of the MALS-1 (MALSU1) mitoribosomal assembly factor. Autism-associated missense variants in RBM-26 cause a sharp decrease in RBM-26 protein expression along with defects i …
We report that RBM-26 (RBM26/27) protects against axonal defects by negatively regulating expression of the MALS-1 (MALSU1) mitoribos …