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2012 184
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4,266 results

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Page 1
Monoamine oxidase A (MAOA): A promising target for prostate cancer therapy.
Han H, Li H, Ma Y, Zhao Z, An Q, Zhao J, Shi C. Han H, et al. Cancer Lett. 2023 Jun 1;563:216188. doi: 10.1016/j.canlet.2023.216188. Epub 2023 Apr 17. Cancer Lett. 2023. PMID: 37076041 Review.
Moreover, MAOA expression is upregulated not only in cancer cells but also in stromal cells, intratumoral T cells, and tumor-associated macrophages; thus, targeting MAOA can be a multi-pronged approach to disrupt tumor promoting interactions between PCa cells and tu …
Moreover, MAOA expression is upregulated not only in cancer cells but also in stromal cells, intratumoral T cells, and tumor-associat …
MAOA deficiency and abnormal behaviour: perspectives on an association.
Brunner HG. Brunner HG. Ciba Found Symp. 1996;194:155-64; discussion 164-7. doi: 10.1002/9780470514825.ch9. Ciba Found Symp. 1996. PMID: 8862875 Review.
Even if the possible relationship between MAOA deficiency and abnormal behaviour is confirmed in other kindreds, the data do not support the hypothesis that MAOA constitutes an "aggression gene'. In fact, because genes are essentially simple and behaviour is by defi …
Even if the possible relationship between MAOA deficiency and abnormal behaviour is confirmed in other kindreds, the data do not supp …
MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1-cMET signaling.
Yin L, Li J, Wang J, Pu T, Wei J, Li Q, Wu BJ. Yin L, et al. Oncogene. 2021 Feb;40(7):1362-1374. doi: 10.1038/s41388-020-01615-2. Epub 2021 Jan 8. Oncogene. 2021. PMID: 33420365 Free PMC article.
Here, we report that monoamine oxidase A (MAOA) is a clinically and functionally important mediator of PNI in PC. MAOA promotes PNI of PC cells in vitro and tumor innervation in an orthotopic xenograft model. ...Collectively, these findings characterize the contribu …
Here, we report that monoamine oxidase A (MAOA) is a clinically and functionally important mediator of PNI in PC. MAOA promote …
MAOA-LPR polymorphism and math anxiety: A marker of genetic susceptibility to social influences in girls?
Carvalho MRS, Barbosa de Carvalho AH, Paiva GM, Andrade Jorge CC, Dos Santos FC, Koltermann G, de Salles JF, Moeller K, Maia de Oliveira Wood G, Haase VG. Carvalho MRS, et al. Ann N Y Acad Sci. 2022 Oct;1516(1):135-150. doi: 10.1111/nyas.14814. Epub 2022 Jun 28. Ann N Y Acad Sci. 2022. PMID: 35765118
MAOA-LPR genotypes were classified as high (MAOA-H) or low (MAOA-L) according to their predicted enzymatic activity. ...The best fitting model included school, math achievement, sex, MAOA-LPR, and the MAOA-LPR by sex interaction. This indicated …
MAOA-LPR genotypes were classified as high (MAOA-H) or low (MAOA-L) according to their predicted enzymatic activity. .. …
MAOA-mediated reprogramming of stromal fibroblasts promotes prostate tumorigenesis and cancer stemness.
Li J, Pu T, Yin L, Li Q, Liao CP, Wu BJ. Li J, et al. Oncogene. 2020 Apr;39(16):3305-3321. doi: 10.1038/s41388-020-1217-4. Epub 2020 Feb 17. Oncogene. 2020. PMID: 32066880
MAOA in stromal fibroblasts provides tumor cell growth advantages through paracrine IL-6/STAT3 signaling. ...Collectively, these findings characterize the contribution of MAOA to stromal activation in PC pathogenesis and provide a rationale for targeting MAOA …
MAOA in stromal fibroblasts provides tumor cell growth advantages through paracrine IL-6/STAT3 signaling. ...Collectively, these find …
CircRHOBTB3 suppresses MAOA by promoting cytoplasmic retention of NONO to inhibit prostate cancer proliferation and metastasis.
Song Y, Zhang C, Shao D, Song X, Han D, Liu J, Xie X, Zhao M, Wei Z, Xu G, Wang S, Chen G. Song Y, et al. Cancer Lett. 2025 Oct 28;631:217910. doi: 10.1016/j.canlet.2025.217910. Epub 2025 Jul 16. Cancer Lett. 2025. PMID: 40680813 Free article.
Mechanistically, circRHOBTB3 binds to the non-POU domain-containing octamer-binding protein (NONO), a transcription factor for monoamine oxidase A (MAOA), sequestering NONO in the cytoplasm and preventing it from upregulating MAOA transcription. This results in decr …
Mechanistically, circRHOBTB3 binds to the non-POU domain-containing octamer-binding protein (NONO), a transcription factor for monoamine oxi …
MAOA methylation is associated with impulsive and antisocial behaviour: dependence on allelic variation, family environment and diet.
Kanarik M, Sakala K, Matrov D, Kaart T, Roy A, Ziegler GC, Veidebaum T, Lesch KP, Harro J. Kanarik M, et al. J Neural Transm (Vienna). 2024 Jan;131(1):59-71. doi: 10.1007/s00702-023-02675-w. Epub 2023 Jul 29. J Neural Transm (Vienna). 2024. PMID: 37507512
Congenital absence of monoamine oxidase A (MAO-A) activity predisposes to antisocial impulsive behaviour, and the MAOA uVNTR low-expressing genotype (MAOA-L) together with childhood maltreatment is associated with similar phenotypes in males. ...CpG3 methylation was …
Congenital absence of monoamine oxidase A (MAO-A) activity predisposes to antisocial impulsive behaviour, and the MAOA uVNTR low-expr …
The forensic use of behavioral genetics in criminal proceedings: Case of the MAOA-L genotype.
McSwiggan S, Elger B, Appelbaum PS. McSwiggan S, et al. Int J Law Psychiatry. 2017 Jan-Feb;50:17-23. doi: 10.1016/j.ijlp.2016.09.005. Epub 2016 Nov 4. Int J Law Psychiatry. 2017. PMID: 27823806 Free PMC article. Review.
Research has suggested that a low activity genotype of the enzyme monoamine oxidase (MAOA-L) may increase the risk for aggressive and antisocial behavior. By examining criminal proceedings in which MAOA-L genotype evidence was introduced, we explored the forensic us …
Research has suggested that a low activity genotype of the enzyme monoamine oxidase (MAOA-L) may increase the risk for aggressive and …
A novel MAOA gene variant: Brunner syndrome, a rare syndrome, is associated with a wide range of psychiatric symptoms.
Ünsel-Bolat G, Turan S, Bolat H. Ünsel-Bolat G, et al. Int J Dev Neurosci. 2024 Dec;84(8):972-976. doi: 10.1002/jdn.10390. Epub 2024 Oct 25. Int J Dev Neurosci. 2024. PMID: 39450862
Brunner syndrome is a rare genetic disorder that associated with mutations in the MAOA gene. It has been linked to a number of psychiatric disorders. We present detailed information on psychiatric evaluation of a case carrying a novel MAOA gene variant of p....Our f …
Brunner syndrome is a rare genetic disorder that associated with mutations in the MAOA gene. It has been linked to a number of psychi …
MAOA suppresses the growth of gastric cancer by interacting with NDRG1 and regulating the Warburg effect through the PI3K/AKT/mTOR pathway.
Wang YY, Zhou YQ, Xie JX, Zhang X, Wang SC, Li Q, Hu LP, Jiang SH, Yi SQ, Xu J, Cao H, Zhao EH, Li J. Wang YY, et al. Cell Oncol (Dordr). 2023 Oct;46(5):1429-1444. doi: 10.1007/s13402-023-00821-w. Epub 2023 May 30. Cell Oncol (Dordr). 2023. PMID: 37249744
MAOA suppressed tumour growth and glycolysis and promoted cancer cell apoptosis. We also reported that MAOA can interact with NDRG1 and regulate glycolysis through suppression of the PI3K/Akt/mTOR pathway. MAOA expression may serve as an independent prognosti …
MAOA suppressed tumour growth and glycolysis and promoted cancer cell apoptosis. We also reported that MAOA can interact with …
4,266 results