Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2017 2
2018 2
2019 2
2020 2
2021 2
2022 1
2024 2
2025 1
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

10 results

Results by year

Filters applied: . Clear all
Page 1
A scoping review shows that several nonvalidated budget planning tools for randomized trials are available.
Speich B, Gloy V, Schur N, Ewald H, Hemkens LG, Schwenkglenks M, Briel M; MAking Randomized Trials Affordable (MARTA) Group. Speich B, et al. J Clin Epidemiol. 2020 Jan;117:9-19. doi: 10.1016/j.jclinepi.2019.09.009. Epub 2019 Sep 15. J Clin Epidemiol. 2020. PMID: 31533072
OBJECTIVES: We aimed to provide a systematic overview of freely available tools which may help plan or monitor costs for randomized clinical trials (RCTs). STUDY DESIGN AND SETTING: We systematically searched MEDLINE, EMBASE, and EconLit and conducted …
OBJECTIVES: We aimed to provide a systematic overview of freely available tools which may help plan or monitor costs for randomize …
Systematic review on costs and resource use of randomized clinical trials shows a lack of transparent and comprehensive data.
Speich B, von Niederhäusern B, Schur N, Hemkens LG, Fürst T, Bhatnagar N, Alturki R, Agarwal A, Kasenda B, Pauli-Magnus C, Schwenkglenks M, Briel M; MAking Randomized Trials Affordable (MARTA) Group. Speich B, et al. J Clin Epidemiol. 2018 Apr;96:1-11. doi: 10.1016/j.jclinepi.2017.12.018. Epub 2017 Dec 27. J Clin Epidemiol. 2018. PMID: 29288136
OBJECTIVES: Randomized clinical trials (RCTs) are costly. We aimed to provide a systematic overview of the available evidence on resource use and costs for RCTs to support budget planning. ...None of the articles provided empirical resource use and …
OBJECTIVES: Randomized clinical trials (RCTs) are costly. We aimed to provide a systematic overview of the available ev …
Design and rationale for an empirical investigation of the resource use and costs of investigator-initiated randomized trials in Switzerland, the UK, and Germany.
Griessbach A, Speich B, Dutilh G, Treweek S, Schwenkglenks M, Briel M; MAking Randomized Trials Affordable (MARTA) Group. Griessbach A, et al. Trials. 2024 Oct 7;25(1):662. doi: 10.1186/s13063-024-08505-y. Trials. 2024. PMID: 39375767 Free PMC article.
BACKGROUND: Conducting high-quality randomized clinical trials (RCTs) is challenging, time consuming, and resource intense. Academic investigators usually depend on scarce financial resources; however, current literature lacks systematically collected empiric …
BACKGROUND: Conducting high-quality randomized clinical trials (RCTs) is challenging, time consuming, and resource inte …
Resource use and costs of investigator-sponsored randomized clinical trials in Switzerland, Germany, and the United Kingdom: a metaresearch study.
Griessbach A, Speich B, Amstutz A, Hausheer L, Covino M, Wnfried Ramirez H, Schandelmaier S, Taji Heravi A, Treweek S, Schwenkglenks M, Briel M; MAking Randomized Trials Affordable (MARTA) Group. Griessbach A, et al. J Clin Epidemiol. 2024 Dec;176:111536. doi: 10.1016/j.jclinepi.2024.111536. Epub 2024 Sep 21. J Clin Epidemiol. 2024. PMID: 39307405 Free article.
BACKGROUND AND OBJECTIVES: Conducting high-quality randomized clinical trials (RCTs) is challenging and resource intensive. Funders and academic investigators depend on limited financial resources and, therefore, need empirical data for optimal budget plannin …
BACKGROUND AND OBJECTIVES: Conducting high-quality randomized clinical trials (RCTs) is challenging and resource intens …
A meta-research study revealed several challenges in obtaining placebos for investigator-initiated drug trials.
Speich B, Logullo P, Deuster S, Marian IR, Moschandreas J, Taji Heravi A, Gloy V, Briel M, Hopewell S; MAking Randomized Trials Affordable (MARTA) Group. Speich B, et al. J Clin Epidemiol. 2021 Mar;131:70-78. doi: 10.1016/j.jclinepi.2020.11.007. Epub 2020 Nov 24. J Clin Epidemiol. 2021. PMID: 33242608 Free article.
OBJECTIVES: To systematically assess the kind of placebos used in investigator-initiated randomized controlled trials (RCTs), from where they are obtained, and the hurdles that exist in obtaining them. STUDY DESIGN AND SETTING: PubMed was searched for recently publi …
OBJECTIVES: To systematically assess the kind of placebos used in investigator-initiated randomized controlled trials (RCTs), …
Practices and Attitudes of Swiss Stakeholders Regarding Investigator-Initiated Clinical Trial Funding Acquisition and Cost Management.
McLennan S, Griessbach A, Briel M; Making Randomized Trials Affordable (MARTA) Group. McLennan S, et al. JAMA Netw Open. 2021 Jun 1;4(6):e2111847. doi: 10.1001/jamanetworkopen.2021.11847. JAMA Netw Open. 2021. PMID: 34076698 Free PMC article.
IMPORTANCE: Randomized clinical trials (RCTs) are an essential method of evaluating health care interventions and a cornerstone for evidence-based health care. However, RCTs have become increasingly complex and costly, which is particularly challenging for in …
IMPORTANCE: Randomized clinical trials (RCTs) are an essential method of evaluating health care interventions and a cor …
Clinical trial budgeting approaches in Switzerland-a meta-research study.
Griessbach A, Chiaborelli M, Ehrlich K, Grossmann R, De Medina Redondo M, Fayet A, Maier R, Trelle S, Gayet-Ageron A, Ceschi A, Speich B, Briel M; MAking Randomized Trials Affordable (MARTA) Group. Griessbach A, et al. Trials. 2025 May 14;26(1):158. doi: 10.1186/s13063-025-08855-1. Trials. 2025. PMID: 40369668 Free PMC article.
BACKGROUND: Conducting clinical trials is resource demanding. Mirroring challenges experienced elsewhere, clinical trials conducted in Switzerland often face overoptimistic budget estimations and insufficient funding, leading to trial discontinu …
BACKGROUND: Conducting clinical trials is resource demanding. Mirroring challenges experienced elsewhere, clinical t …
Investigational medicinal products, related costs and hospital pharmacy services for investigator-initiated trials: A mixed-methods study.
Taji Heravi A, Henn A, Deuster S, McLennan S, Gloy V, Mitter VR, Briel M; MAking Randomized Trials Affordable (MARTA) Group. Taji Heravi A, et al. PLoS One. 2022 Mar 4;17(3):e0264427. doi: 10.1371/journal.pone.0264427. eCollection 2022. PLoS One. 2022. PMID: 35245312 Free PMC article.
METHODS: We included all IITs with IMP services from the Basel hospital pharmacy invoiced between January 2014 and June 2020 (n = 24). We documented trial and IMP characteristics including planned and actual IMP costs. Our working definition for a substantial cos …
METHODS: We included all IITs with IMP services from the Basel hospital pharmacy invoiced between January 2014 and June 2020 (n = 24). We do …
Current use and costs of electronic health records for clinical trial research: a descriptive study.
Mc Cord KA, Ewald H, Ladanie A, Briel M, Speich B, Bucher HC, Hemkens LG; RCD for RCTs initiative and the Making Randomized Trials More Affordable Group. Mc Cord KA, et al. CMAJ Open. 2019 Feb 3;7(1):E23-E32. doi: 10.9778/cmajo.20180096. Print 2019 Jan-Mar. CMAJ Open. 2019. PMID: 30718353 Free PMC article.
BACKGROUND: Electronic health records (EHRs) may support randomized controlled trials (RCTs). We aimed to describe the current use and costs of EHRs in RCTs, with a focus on recruitment and outcome assessment. ...The per-patient cost in the 17 EHR-supp …
BACKGROUND: Electronic health records (EHRs) may support randomized controlled trials (RCTs). We aimed to describe the current …
Retrospective assessment of resource use and costs in two investigator-initiated randomized trials exemplified a comprehensive cost item list.
Speich B, von Niederhäusern B, Blum CA, Keiser J, Schur N, Fürst T, Kasenda B, Christ-Crain M, Hemkens LG, Pauli-Magnus C, Schwenkglenks M, Briel M; MAking Randomized Trials Affordable (MARTA) Group. Speich B, et al. J Clin Epidemiol. 2018 Apr;96:73-83. doi: 10.1016/j.jclinepi.2017.12.022. Epub 2017 Dec 30. J Clin Epidemiol. 2018. PMID: 29292203
OBJECTIVES: Randomized clinical trials (RCTs) are costly and published information on resource requirements for their conduct is limited. ...Cost drivers were similar between the two RCTs with recruitment delays explaining the additional costs i …
OBJECTIVES: Randomized clinical trials (RCTs) are costly and published information on resource requirements for their c …