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266 results

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Page 1
MBOAT7 in liver and extrahepatic diseases.
Caddeo A, Spagnuolo R, Maurotti S. Caddeo A, et al. Liver Int. 2023 Nov;43(11):2351-2364. doi: 10.1111/liv.15706. Epub 2023 Aug 22. Liver Int. 2023. PMID: 37605540 Review.
In this review, we will (a) elucidate the molecular mechanisms by which MBOAT7 loss-of-function predisposes to MAFLD and neurodevelopmental disorders and (b) discuss the growing number of genetic studies linking MBOAT7 to hepatic and extrahepatic diseases. MBOAT7 …
In this review, we will (a) elucidate the molecular mechanisms by which MBOAT7 loss-of-function predisposes to MAFLD and neurodevelop …
MBOAT7 down-regulation by genetic and environmental factors predisposes to MAFLD.
Meroni M, Longo M, Fracanzani AL, Dongiovanni P. Meroni M, et al. EBioMedicine. 2020 Jul;57:102866. doi: 10.1016/j.ebiom.2020.102866. Epub 2020 Jul 3. EBioMedicine. 2020. PMID: 32629394 Free PMC article. Review.
However, the predisposition to develop MAFLD is severely influenced by environmental and inherited cues. The rs641738 variant close to MBOAT7 gene has been identified by a genome-wide association screening in heavy drinkers. ...This review aims to summarize the clinical an …
However, the predisposition to develop MAFLD is severely influenced by environmental and inherited cues. The rs641738 variant close to MB …
Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease.
Varadharajan V, Massey WJ, Brown JM. Varadharajan V, et al. J Lipid Res. 2022 Jul;63(7):100234. doi: 10.1016/j.jlr.2022.100234. Epub 2022 May 27. J Lipid Res. 2022. PMID: 35636492 Free PMC article. Review.
An important advance has been made within the past several years, as several genome-wide association studies have discovered that an SNP near the gene encoding membrane-bound O-acyltransferase 7 (MBOAT7) is associated with severe liver diseases. This common MBOAT7 v …
An important advance has been made within the past several years, as several genome-wide association studies have discovered that an SNP nea …
MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis.
Massey WJ, Varadharajan V, Banerjee R, Brown AL, Horak AJ, Hohe RC, Jung BM, Qiu Y, Chan ER, Pan C, Zhang R, Allende DS, Willard B, Cheng F, Lusis AJ, Brown JM. Massey WJ, et al. J Lipid Res. 2023 Apr;64(4):100349. doi: 10.1016/j.jlr.2023.100349. Epub 2023 Feb 18. J Lipid Res. 2023. PMID: 36806709 Free PMC article.
We generated Mboat7 floxed mice and created hepatocyte- and adipocyte-specific Mboat7 knockout mice using Cre-recombinase mice under the control of the albumin and adiponectin promoter, respectively. ...Unlike in the liver, where Mboat7 plays a relatively min …
We generated Mboat7 floxed mice and created hepatocyte- and adipocyte-specific Mboat7 knockout mice using Cre-recombinase mice …
Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury.
Varadharajan V, Ramachandiran I, Massey WJ, Jain R, Banerjee R, Horak AJ, McMullen MR, Huang E, Bellar A, Lorkowski SW, Gulshan K, Helsley RN, James I, Pathak V, Dasarathy J, Welch N, Dasarathy S, Streem D, Reizes O, Allende DS, Smith JD, Simcox J, Nagy LE, Brown JM. Varadharajan V, et al. Elife. 2024 Apr 22;12:RP92243. doi: 10.7554/eLife.92243. Elife. 2024. PMID: 38648183 Free PMC article.
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver diseases. Specifically, the common MBOAT7 variant (rs641738) associated with reduced MBOAT7 expression …
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 g …
MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis.
Phadnis VV, Snider J, Varadharajan V, Ramachandiran I, Deik AA, Lai ZW, Kunchok T, Eaton EN, Sebastiany C, Lyakisheva A, Vaccaro KD, Allen J, Yao Z, Wong V, Geng B, Weiskopf K, Clish CB, Brown JM, Stagljar I, Weinberg RA, Henry WS. Phadnis VV, et al. Cell Rep. 2023 Sep 26;42(9):113023. doi: 10.1016/j.celrep.2023.113023. Epub 2023 Sep 8. Cell Rep. 2023. PMID: 37691145 Free PMC article.
Here, we reveal that an understudied Golgi-resident scaffold protein, MMD, promotes susceptibility to ferroptosis in ovarian and renal carcinoma cells in an ACSL4- and MBOAT7-dependent manner. Mechanistically, MMD physically interacts with both ACSL4 and MBOAT7, two …
Here, we reveal that an understudied Golgi-resident scaffold protein, MMD, promotes susceptibility to ferroptosis in ovarian and renal carci …
Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation.
Moore MP, Wang X, Kennelly JP, Shi H, Ishino Y, Kano K, Aoki J, Cherubini A, Ronzoni L, Guo X, Chalasani NP, Khalid S, Saleheen D, Mitsche MA, Rotter JI, Yates KP, Valenti L, Kono N, Tontonoz P, Tabas I. Moore MP, et al. Hepatology. 2025 Feb 1;81(2):576-590. doi: 10.1097/HEP.0000000000000933. Epub 2024 May 22. Hepatology. 2025. PMID: 38776184 Free PMC article.
Conversely, when hepatocyte-MBOAT7 was silenced in mice with established hepatosteatosis, liver fibrosis but not hepatosteatosis was exacerbated. ...Conversely, hepatocyte-MBOAT7 silencing enhanced TAZ upregulation in MASH. Finally, we discovered that changes in hep …
Conversely, when hepatocyte-MBOAT7 was silenced in mice with established hepatosteatosis, liver fibrosis but not hepatosteatosis was …
rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis.
Teo K, Abeysekera KWM, Adams L, Aigner E, Anstee QM, Banales JM, Banerjee R, Basu P, Berg T, Bhatnagar P, Buch S, Canbay A, Caprio S, Chatterjee A, Ida Chen YD, Chowdhury A, Daly AK, Datz C, de Gracia Hahn D, DiStefano JK, Dong J, Duret A; EU-PNAFLD Investigators; Emdin C, Fairey M, Gerhard GS; GOLD Consortium; Guo X, Hampe J, Hickman M, Heintz L, Hudert C, Hunter H, Kelly M, Kozlitina J, Krawczyk M, Lammert F, Langenberg C, Lavine J, Li L, Lim HK, Loomba R, Luukkonen PK, Melton PE, Mori TA, Palmer ND, Parisinos CA, Pillai SG, Qayyum F, Reichert MC, Romeo S, Rotter JI, Im YR, Santoro N, Schafmayer C, Speliotes EK, Stender S, Stickel F, Still CD, Strnad P, Taylor KD, Tybjærg-Hansen A, Umano GR, Utukuri M, Valenti L, Wagenknecht LE, Wareham NJ, Watanabe RM, Wattacheril J, Yaghootkar H, Yki-Järvinen H, Young KA, Mann JP. Teo K, et al. J Hepatol. 2021 Jan;74(1):20-30. doi: 10.1016/j.jhep.2020.08.027. Epub 2020 Aug 31. J Hepatol. 2021. PMID: 32882372 Free PMC article.
We did this study to see whether one specific change ('variant') in one gene ('MBOAT7') was linked to fatty liver disease. We took data from over 40 published studies and found that this variant near MBOAT7 is linked to more severe fatty liver disease. This means th …
We did this study to see whether one specific change ('variant') in one gene ('MBOAT7') was linked to fatty liver disease. We took da …
MBOAT7 is anchored to endomembranes by six transmembrane domains.
Caddeo A, Jamialahmadi O, Solinas G, Pujia A, Mancina RM, Pingitore P, Romeo S. Caddeo A, et al. J Struct Biol. 2019 Jun 1;206(3):349-360. doi: 10.1016/j.jsb.2019.04.006. Epub 2019 Apr 5. J Struct Biol. 2019. PMID: 30959108 Free article.
Although it has been shown that MBOAT7 is associated to membranes, the MBOAT7 topology remains unknown. To solve the topological organization of MBOAT7, we performed: A) solubilization of the total membrane fraction of cells overexpressing the recombinant …
Although it has been shown that MBOAT7 is associated to membranes, the MBOAT7 topology remains unknown. To solve the topologic …
Enhancing Hepatic MBOAT7 Expression in Mice With Nonalcoholic Steatohepatitis.
Sharpe MC, Pyles KD, Hallcox T, Kamm DR, Piechowski M, Fisk B, Albert CJ, Carpenter DH, Ulmasov B, Ford DA, Neuschwander-Tetri BA, McCommis KS. Sharpe MC, et al. Gastro Hep Adv. 2023;2(4):558-572. doi: 10.1016/j.gastha.2023.02.004. Epub 2023 Feb 23. Gastro Hep Adv. 2023. PMID: 37293574 Free PMC article.
We hypothesized that enhancing MBOAT7 function would improve NASH. METHODS: Genomic and lipidomic databases were mined for MBOAT7 expression and hepatic phosphatidylinositol (PI) abundance in human NAFLD/NASH. ...After MBOAT7 overexpression, liver weights, tr …
We hypothesized that enhancing MBOAT7 function would improve NASH. METHODS: Genomic and lipidomic databases were mined for MBOAT7 …
266 results