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Diagnosis of mast cell activation syndrome: a global "consensus-2".
Afrin LB, Ackerley MB, Bluestein LS, Brewer JH, Brook JB, Buchanan AD, Cuni JR, Davey WP, Dempsey TT, Dorff SR, Dubravec MS, Guggenheim AG, Hindman KJ, Hoffman B, Kaufman DL, Kratzer SJ, Lee TM, Marantz MS, Maxwell AJ, McCann KK, McKee DL, Menk Otto L, Pace LA, Perkins DD, Radovsky L, Raleigh MS, Rapaport SA, Reinhold EJ, Renneker ML, Robinson WA, Roland AM, Rosenbloom ES, Rowe PC, Ruhoy IS, Saperstein DS, Schlosser DA, Schofield JR, Settle JE, Weinstock LB, Wengenroth M, Westaway M, Xi SC, Molderings GJ. Afrin LB, et al. Diagnosis (Berl). 2020 Apr 22;8(2):137-152. doi: 10.1515/dx-2020-0005. Print 2021 May 26. Diagnosis (Berl). 2020. PMID: 32324159 Review.
The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of "mast cell activation syndrome" ( …
The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross …
The Relationship Between Hypermobile Ehlers-Danlos Syndrome (hEDS), Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS).
Kucharik AH, Chang C. Kucharik AH, et al. Clin Rev Allergy Immunol. 2020 Jun;58(3):273-297. doi: 10.1007/s12016-019-08755-8. Clin Rev Allergy Immunol. 2020. PMID: 31267471 Review.
All three clinical entities are controversial in either existence or pathogenesis. MCAS is a poorly defined clinical entity, and many studies do not adhere to the proposed criteria when establishing the diagnosis. Patients previously diagnosed with EDS hypermobility …
All three clinical entities are controversial in either existence or pathogenesis. MCAS is a poorly defined clinical entity, and many …
The relationship between mast cell activation syndrome, postural tachycardia syndrome, and Ehlers-Danlos syndrome.
Wang E, Ganti T, Vaou E, Hohler A. Wang E, et al. Allergy Asthma Proc. 2021 May 1;42(3):243-246. doi: 10.2500/aap.2021.42.210022. Allergy Asthma Proc. 2021. PMID: 33980338
The demographics of the patients and diagnoses of POTS, EDS, or MCAS were recorded. Confidence intervals of the proportion of patients MCAS within a population of patients with POTS and EDS were compared with the proportion of patients with MCAS …
The demographics of the patients and diagnoses of POTS, EDS, or MCAS were recorded. Confidence intervals of the proportion of …
Dysautonomia, Hypermobility Spectrum Disorders and Mast Cell Activation Syndrome as Migraine Comorbidities.
Blitshteyn S. Blitshteyn S. Curr Neurol Neurosci Rep. 2023 Nov;23(11):769-776. doi: 10.1007/s11910-023-01307-w. Epub 2023 Oct 17. Curr Neurol Neurosci Rep. 2023. PMID: 37847487 Review.
Diagnostic criteria, pathophysiologic mechanisms, and therapeutic considerations in patients with migraine and comorbid dysautonomia, HSD, and MCAS are reviewed. RECENT FINDINGS: Numerous studies indicate a significant overlap and shared pathophysiology in migraine, dysaut …
Diagnostic criteria, pathophysiologic mechanisms, and therapeutic considerations in patients with migraine and comorbid dysautonomia, HSD, a …
Removal of Polymer Clips From the Gallbladder Fossa in a Patient With Ehlers-Danlos Syndrome (EDS) to Treat Mast Cell Activation Syndrome (MCAS): A Case Report.
Xiao Y, Calixte DA, Fry E, Tiesenga F. Xiao Y, et al. Cureus. 2023 Jan 12;15(1):e33704. doi: 10.7759/cureus.33704. eCollection 2023 Jan. Cureus. 2023. PMID: 36788923 Free PMC article.
Ehlers-Danlos syndrome (EDS) is a group of hereditary disorders characterized by fragility of connective tissue. ...We report the case of a 29-year-old female suffering from EDS and mast cell activation syndrome (MCAS). Her history includes multiple orthopedi …
Ehlers-Danlos syndrome (EDS) is a group of hereditary disorders characterized by fragility of connective tissue. ...We report the cas …
Autonomic symptom burden, comorbidities and quality of life in women with Hypermobility Spectrum Disorders and hypermobile Ehlers-Danlos syndrome.
Collins Hutchinson ML, Liang E, Fuster E, Blitshteyn S. Collins Hutchinson ML, et al. Auton Neurosci. 2025 Dec;262:103356. doi: 10.1016/j.autneu.2025.103356. Epub 2025 Oct 14. Auton Neurosci. 2025. PMID: 41118678
Importantly, 25 % of patients reported having all three diagnoses: HSD/h-EDS, POTS and MCAS. Mean COMPASS-31 score was 54.45 (range 18.79-80.93), indicating severe autonomic dysfunction, which was significantly higher than in patients with multiple sclerosis, diabet …
Importantly, 25 % of patients reported having all three diagnoses: HSD/h-EDS, POTS and MCAS. Mean COMPASS-31 score was 54.45 ( …
Association between Ehlers-Danlos syndrome and mast cell activation syndrome: Is there scientific evidence?
Cuenca-Gómez JA, Dawid-Milner MS, Sánchez-Martínez R. Cuenca-Gómez JA, et al. Rev Clin Esp (Barc). 2026 Feb;226(2):502457. doi: 10.1016/j.rceng.2026.502457. Epub 2026 Jan 17. Rev Clin Esp (Barc). 2026. PMID: 41554340 Review.
Ehlers-Danlos Syndromes (EDS) are hereditary connective tissue disorders that affect multiple systems. Mast Cell Activation Syndrome (MCAS) is a clinical condition characterized by chronic and aberrant activation of mast cells. ...For example, pathophysiologically, …
Ehlers-Danlos Syndromes (EDS) are hereditary connective tissue disorders that affect multiple systems. Mast Cell Activation Syndrome …
Scroll, like, diagnose? Evaluating mast cell activation syndrome information on TikTok.
Gansert E, Estrada-Mendizabal RJ, Farley MM, Voelker DH, Gonzalez-Estrada A. Gansert E, et al. Allergy Asthma Proc. 2026 Jan 1;47(1):e1-e3. doi: 10.2500/aap.2026.47.250090. Allergy Asthma Proc. 2026. PMID: 41514191
The profession of the content creator, use of MCAS Vienna diagnostic criteria, association with postural orthostatic syndrome (POTS)/Ehlers Danlos syndrome (EDS), and information trends were also analyzed. ...Most videos were created by health-care professionals (58 …
The profession of the content creator, use of MCAS Vienna diagnostic criteria, association with postural orthostatic syndrome (POTS)/ …
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