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Page 1
Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer's disease microglia.
Huang AY, Zhou Z, Talukdar M, Miller MB, Chhouk B, Enyenihi L, Rosen I, Stronge E, Zhao B, Kim D, Choi J, Khoshkhoo S, Kim J, Ganz J, Travaglini K, Gabitto M, Hodge R, Kaplan E, Lein E, De Jager PL, Bennett DA, Lee EA, Walsh CA. Huang AY, et al. bioRxiv [Preprint]. 2024 Jan 4:2024.01.03.574078. doi: 10.1101/2024.01.03.574078. bioRxiv. 2024. PMID: 38260600 Free PMC article. Preprint.
Somatic mutations accumulate with age and lead to clonal expansion of many cell types, contributing to cancer and many non-cancer diseases(6,7). Here we studied somatic mutation in normal aged and AD brains by three orthogonal methods and in three independent AD cohorts. . …
Somatic mutations accumulate with age and lead to clonal expansion of many cell types, contributing to cancer and many non-cancer disease …
Spectrum of mast cell activation disorders.
Petra AI, Panagiotidou S, Stewart JM, Conti P, Theoharides TC. Petra AI, et al. Expert Rev Clin Immunol. 2014 Jun;10(6):729-39. doi: 10.1586/1744666X.2014.906302. Epub 2014 May 1. Expert Rev Clin Immunol. 2014. PMID: 24784142 Review.
These disorders are classified as: cutaneous and systemic mastocytosis with a c-kit mutation and clonal MC activation disorder, allergies, urticarias and inflammatory disorders and mast cell activation syndrome (MCAS), idiopathic urticaria and angioedema. MCs are activated …
These disorders are classified as: cutaneous and systemic mastocytosis with a c-kit mutation and clonal MC activation disorder, allergies, u …
Psychometric validation of the French Multidimensional Chronic Asthenia Scale (MCAS) in a sample of 621 patients with chronic fatigue.
Banovic I, Scrima F, Fornasieri I, Beaugerie L, Coquart J, Fourgon C, Iodice P, Nion-Larmurier I, Savoye G, Sorin AL, Tourny C, Augustinova M. Banovic I, et al. BMC Psychol. 2023 Oct 10;11(1):324. doi: 10.1186/s40359-023-01358-1. BMC Psychol. 2023. PMID: 37817287 Free PMC article.
While convergent-discriminant validity between the 4 factors of MCAS and FSI and r-PFS, respectively, was satisfactory overall, Step 3 also pointed to some limitations that call for future research (e.g., shared variances between the PC and IC dimensions of MCAS and …
While convergent-discriminant validity between the 4 factors of MCAS and FSI and r-PFS, respectively, was satisfactory overall, Step …
Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue.
Theoharides TC, Cholevas C, Polyzoidis K, Politis A. Theoharides TC, et al. Biofactors. 2021 Mar;47(2):232-241. doi: 10.1002/biof.1726. Epub 2021 Apr 12. Biofactors. 2021. PMID: 33847020 Free PMC article. Review.
Long-COVID syndrome symptoms, especially brain fog, are similar to those experienced by patients undertaking or following chemotherapy for cancer (chemofog or chemobrain), as well in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or mast cell activation …
Long-COVID syndrome symptoms, especially brain fog, are similar to those experienced by patients undertaking or following chemotherapy for c …
IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.
Toth P, Tucsek Z, Tarantini S, Sosnowska D, Gautam T, Mitschelen M, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Toth P, et al. J Cereb Blood Flow Metab. 2014 Dec;34(12):1887-97. doi: 10.1038/jcbfm.2014.156. Epub 2014 Sep 24. J Cereb Blood Flow Metab. 2014. PMID: 25248835 Free PMC article.
In hypertensive control mice, cerebral blood flow (CBF) autoregulation was extended to higher pressure values and the pressure-induced tone of middle cerebral arteries (MCAs) was increased. In hypertensive IGF-1-deficient mice, autoregulation was markedly disrupted, and …
In hypertensive control mice, cerebral blood flow (CBF) autoregulation was extended to higher pressure values and the pressure-induced tone …
Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension.
Toth P, Tucsek Z, Sosnowska D, Gautam T, Mitschelen M, Tarantini S, Deak F, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Toth P, et al. J Cereb Blood Flow Metab. 2013 Nov;33(11):1732-42. doi: 10.1038/jcbfm.2013.143. Epub 2013 Aug 14. J Cereb Blood Flow Metab. 2013. PMID: 23942363 Free PMC article.
Downstream consequences of cerebrovascular autoregulatory dysfunction in aged AngII-induced hypertensive mice included exacerbated disruption of the blood-brain barrier and neuroinflammation (microglia activation and upregulation of proinflammatory cytokines and chemokines …
Downstream consequences of cerebrovascular autoregulatory dysfunction in aged AngII-induced hypertensive mice included exacerbated disruptio …
Time course of cerebral hemodynamics in cryptococcal meningitis in HIV-negative adults.
Chang WN, Lu CH, Chang HW, Lui CC, Tsai NW, Huang CR, Wang HC, Chuang YC, Chen SF, Chang CC. Chang WN, et al. Eur J Neurol. 2007 Jul;14(7):770-6. doi: 10.1111/j.1468-1331.2007.01852.x. Eur J Neurol. 2007. PMID: 17594333
With TCCS, 8 of the 22 middle cerebral arteries (MCAs) showed stenotic velocities, whereas the time-mean velocity (V(mean)) of the 20 anterior cerebral arteries (ACAs), 22 posterior cerebral arteries (PCAs), and 12 basilar arteries (BAs) did not. ...
With TCCS, 8 of the 22 middle cerebral arteries (MCAs) showed stenotic velocities, whereas the time-mean velocity (V(mean)) of the 20 …