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Year Number of Results
2005 1
2006 8
2007 7
2008 8
2009 16
2010 9
2011 3
2020 0
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45 results
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Page 1
PRIMA-1 reactivates mutant p53 by covalent binding to the core domain.
Lambert JM, Gorzov P, Veprintsev DB, Söderqvist M, Segerbäck D, Bergman J, Fersht AR, Hainaut P, Wiman KG, Bykov VJ. Lambert JM, et al. Cancer Cell. 2009 May 5;15(5):376-88. doi: 10.1016/j.ccr.2009.03.003. Cancer Cell. 2009. PMID: 19411067 Free article.
Structure-function-rescue: the diverse nature of common p53 cancer mutants.
Joerger AC, Fersht AR. Joerger AC, et al. Oncogene. 2007 Apr 2;26(15):2226-42. doi: 10.1038/sj.onc.1210291. Oncogene. 2007. PMID: 17401432 Free article. Review.
Adaptive evolution of p53 thermodynamic stability.
Khoo KH, Andreeva A, Fersht AR. Khoo KH, et al. J Mol Biol. 2009 Oct 16;393(1):161-75. doi: 10.1016/j.jmb.2009.08.013. Epub 2009 Aug 13. J Mol Biol. 2009. PMID: 19683006
Effects of stability on the biological function of p53.
Khoo KH, Mayer S, Fersht AR. Khoo KH, et al. J Biol Chem. 2009 Nov 6;284(45):30974-80. doi: 10.1074/jbc.M109.033183. Epub 2009 Aug 21. J Biol Chem. 2009. PMID: 19700401 Free PMC article.
Ultraslow oligomerization equilibria of p53 and its implications.
Natan E, Hirschberg D, Morgner N, Robinson CV, Fersht AR. Natan E, et al. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14327-32. doi: 10.1073/pnas.0907840106. Epub 2009 Aug 10. Proc Natl Acad Sci U S A. 2009. PMID: 19667193 Free PMC article.
S100 proteins interact with the N-terminal domain of MDM2.
van Dieck J, Lum JK, Teufel DP, Fersht AR. van Dieck J, et al. FEBS Lett. 2010 Aug 4;584(15):3269-74. doi: 10.1016/j.febslet.2010.06.024. Epub 2010 Jun 19. FEBS Lett. 2010. PMID: 20591429 Free article.
Members of the S100 family bind p53 in two distinct ways.
Fernandez-Fernandez MR, Rutherford TJ, Fersht AR. Fernandez-Fernandez MR, et al. Protein Sci. 2008 Oct;17(10):1663-70. doi: 10.1110/ps.035527.108. Epub 2008 Aug 11. Protein Sci. 2008. PMID: 18694925 Free PMC article.
Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant.
Basse N, Kaar JL, Settanni G, Joerger AC, Rutherford TJ, Fersht AR. Basse N, et al. Chem Biol. 2010 Jan 29;17(1):46-56. doi: 10.1016/j.chembiol.2009.12.011. Chem Biol. 2010. PMID: 20142040
Core domain interactions in full-length p53 in solution.
Veprintsev DB, Freund SM, Andreeva A, Rutledge SE, Tidow H, Cañadillas JM, Blair CM, Fersht AR. Veprintsev DB, et al. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2115-9. doi: 10.1073/pnas.0511130103. Epub 2006 Feb 6. Proc Natl Acad Sci U S A. 2006. PMID: 16461914 Free PMC article.
Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core.
Khoo KH, Joerger AC, Freund SM, Fersht AR. Khoo KH, et al. Protein Eng Des Sel. 2009 Jul;22(7):421-30. doi: 10.1093/protein/gzp018. Epub 2009 Jun 10. Protein Eng Des Sel. 2009. PMID: 19515728 Free PMC article.
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