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193 results

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Page 1
Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders.
Cohen J, Mathew A, Dourvetakis KD, Sanchez-Guerrero E, Pangeni RP, Gurusamy N, Aenlle KK, Ravindran G, Twahir A, Isler D, Sosa-Garcia SR, Llizo A, Bested AC, Theoharides TC, Klimas NG, Kempuraj D. Cohen J, et al. Cells. 2024 Mar 14;13(6):511. doi: 10.3390/cells13060511. Cells. 2024. PMID: 38534355 Free PMC article. Review.
These disorders show dysregulated neuroimmune and inflammatory responses, including activation of neurons, glial cells, and neurovascular unit damage associated with excessive release of proinflammatory cytokines, chemokines, neurotoxic mediators, and infiltration of perip …
These disorders show dysregulated neuroimmune and inflammatory responses, including activation of neurons, glial cells, and neurovascular un …
Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit.
Wang H, Yang J, Cai Y, Zhao Y. Wang H, et al. Protein Cell. 2024 Dec 2;15(12):906-929. doi: 10.1093/procel/pwae013. Protein Cell. 2024. PMID: 38530808 Free PMC article.
Direct conversion of cardiac fibroblasts (CFs) to cardiomyocytes (CMs) in vivo to regenerate heart tissue is an attractive approach. ...However, whether and how the MI microenvironment influences the reprogramming of CFs remains unclear. Here, we found that in compa …
Direct conversion of cardiac fibroblasts (CFs) to cardiomyocytes (CMs) in vivo to regenerate heart tissue is an attractive approach. …
Mechanistic Insights Into Long Covid: Viral Persistence, Immune Dysregulation, and Multi-Organ Dysfunction.
Gupta G, Buonsenso D, Wood J, Mohandas S, Warburton D. Gupta G, et al. Compr Physiol. 2025 Jun;15(3):e70019. doi: 10.1002/cph4.70019. Compr Physiol. 2025. PMID: 40474772 Review.
Current literature suggests that the mechanisms causing Long Covid involve viral persistence, immune dysregulation, systemic inflammation, endothelial dysfunction, and metabolic disturbances. By forming reservoirs in the tissues of various organs, SARS-CoV-2 may evade immu …
Current literature suggests that the mechanisms causing Long Covid involve viral persistence, immune dysregulation, systemic inflammation …
Exploring the joint potential of inflammation, immunity, and receptor-based biomarkers for evaluating ME/CFS progression.
Berkis U, Svirskis S, Krumina A, Gravelsina S, Vilmane A, Araja D, Nora-Krukle Z, Murovska M. Berkis U, et al. Front Immunol. 2023 Dec 20;14:1294758. doi: 10.3389/fimmu.2023.1294758. eCollection 2023. Front Immunol. 2023. PMID: 38187396 Free PMC article.
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition with no identified diagnostic biomarkers to date. ...DISCUSSION: The association between inflammatome and immunome markers is a candidate for controlled clinical stu …
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition with no identified diagno …
The role of low-grade inflammation in ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) - associations with symptoms.
Jonsjö MA, Olsson GL, Wicksell RK, Alving K, Holmström L, Andreasson A. Jonsjö MA, et al. Psychoneuroendocrinology. 2020 Mar;113:104578. doi: 10.1016/j.psyneuen.2019.104578. Epub 2019 Dec 26. Psychoneuroendocrinology. 2020. PMID: 31901625 Free article.
METHODS: 53 adult patients diagnosed with ME/CFS at a specialist clinic were included in the study. Fasting blood plasma was analyzed using the Olink Proseek Multiplex Inflammation panel (beta-NGF, CCL11, CXCL1, CXCL10, IL-6, IL-7, IL-8, IL-10, IL-18, TGF-alpha, TGF …
METHODS: 53 adult patients diagnosed with ME/CFS at a specialist clinic were included in the study. Fasting blood plasma was analyzed …
Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
Kavyani B, Ahn SB, Missailidis D, Annesley SJ, Fisher PR, Schloeffel R, Guillemin GJ, Lovejoy DB, Heng B. Kavyani B, et al. Mol Neurobiol. 2024 Jul;61(7):3771-3787. doi: 10.1007/s12035-023-03784-z. Epub 2023 Nov 28. Mol Neurobiol. 2024. PMID: 38015302
While some evidence links the KP to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), further studies are needed to clarify the overall picture of how inflammation-driven KP disturbances may contribute to symptomology in ME/CFS. ...We also rational …
While some evidence links the KP to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), further studies are needed to clarif …
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS.
Shahbaz S, Osman M, Syed H, Mason A, Rosychuk RJ, Cohen Tervaert JW, Elahi S. Shahbaz S, et al. Cell Rep Med. 2025 Nov 18;6(11):102449. doi: 10.1016/j.xcrm.2025.102449. Epub 2025 Nov 7. Cell Rep Med. 2025. PMID: 41205594 Free PMC article.
Long COVID (LC) manifests with sex-specific differences, particularly in those with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study reveals that female LC patients (LCF) with ME/CFS show a shift toward myelopoiesis, reduced lymphocytes, increa …
Long COVID (LC) manifests with sex-specific differences, particularly in those with myalgic encephalomyelitis/chronic fatigue syndrome (ME/ …
Tetramethoxyluteolin for the Treatment of Neurodegenerative Diseases.
Theoharides TC, Tsilioni I. Theoharides TC, et al. Curr Top Med Chem. 2018;18(21):1872-1882. doi: 10.2174/1568026617666181119154247. Curr Top Med Chem. 2018. PMID: 30451113 Review.
Increasing evidence indicates that such diseases involve focal inflammation of the brain. OBJECTIVE: To review the role of cytokine-neuropeptide interactions in the pathogenesis of inflammation of the brain and the beneficial role of natural flavonoids. ...RE …
Increasing evidence indicates that such diseases involve focal inflammation of the brain. OBJECTIVE: To review the role of cytokin …
The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs).
Morris G, Berk M, Galecki P, Maes M. Morris G, et al. Mol Neurobiol. 2014 Apr;49(2):741-56. doi: 10.1007/s12035-013-8553-0. Epub 2013 Sep 26. Mol Neurobiol. 2014. PMID: 24068616 Review.
Here we review the potential sources of autoimmunity which are observed in people with ME/cfs. The increased levels of pro-inflammatory cytokines, e.g., interleukin-1 and tumor necrosis factor-alpha, and increased levels of nuclear factor-kappaB predispose to an aut …
Here we review the potential sources of autoimmunity which are observed in people with ME/cfs. The increased levels of pro-inflammato …
Diverse immunological dysregulation, chronic inflammation, and impaired erythropoiesis in long COVID patients with chronic fatigue syndrome.
Saito S, Shahbaz S, Osman M, Redmond D, Bozorgmehr N, Rosychuk RJ, Lam G, Sligl W, Cohen Tervaert JW, Elahi S. Saito S, et al. J Autoimmun. 2024 Jul;147:103267. doi: 10.1016/j.jaut.2024.103267. Epub 2024 May 25. J Autoimmun. 2024. PMID: 38797051 Free article.
ME/CFS patients had relatively increased neutrophils and monocytes but reduced lymphocytes. ...Our findings provide a new paradigm in the pathogenesis of ME/CFS to identify strategies for its prevention and treatment....
ME/CFS patients had relatively increased neutrophils and monocytes but reduced lymphocytes. ...Our findings provide a new paradigm in …
193 results