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137 results

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Page 1
Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction.
Tani H, Sadahiro T, Yamada Y, Isomi M, Yamakawa H, Fujita R, Abe Y, Akiyama T, Nakano K, Kuze Y, Seki M, Suzuki Y, Fujisawa M, Sakata-Yanagimoto M, Chiba S, Fukuda K, Ieda M. Tani H, et al. Circulation. 2023 Jan 17;147(3):223-238. doi: 10.1161/CIRCULATIONAHA.121.058655. Epub 2022 Dec 12. Circulation. 2023. PMID: 36503256
BACKGROUND: Because adult cardiomyocytes have little regenerative capacity, resident cardiac fibroblasts (CFs) synthesize extracellular matrix after myocardial infarction (MI) to form fibrosis, leading to cardiac dysfunction and heart failure. ...These findings pres …
BACKGROUND: Because adult cardiomyocytes have little regenerative capacity, resident cardiac fibroblasts (CFs) synthesize extracellul …
Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarction.
Bann GG, Dos Santos M, Chen K, Tan W, Bezprozvannaya S, Gan P, Xu L, Liu N, Bassel-Duby R, Olson EN. Bann GG, et al. Circulation. 2025 Sep 2;152(9):616-629. doi: 10.1161/CIRCULATIONAHA.124.072733. Epub 2025 Jul 9. Circulation. 2025. PMID: 40631661 Free PMC article.
BACKGROUND: Direct reprogramming of fibroblasts to cardiomyocytes is a potentially curative strategy for ischemic heart disease. However, current reprogramming strategies require excessive factors due to epigenetic barriers of adult mouse and human fibroblasts. ...D …
BACKGROUND: Direct reprogramming of fibroblasts to cardiomyocytes is a potentially curative strategy for ischemic heart disease. Howe …
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Xin M, Olson EN, Bassel-Duby R. Xin M, et al. Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10. Nat Rev Mol Cell Biol. 2013. PMID: 23839576 Free PMC article. Review.
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and disease can result in heart failure and death. The cellular processes and regulatory mechanisms involved in heart growth and de …
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and d …
MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure.
Pereira AHM, Cardoso AC, Consonni SR, Oliveira RR, Saito A, Vaggione MLB, Matos-Souza JR, Carazzolle MF, Gonçalves A, Fernandes JL, Ribeiro GCA, Lopes MM, Molkentin JD, Franchini KG. Pereira AHM, et al. EBioMedicine. 2020 Jan;51:102571. doi: 10.1016/j.ebiom.2019.11.032. Epub 2020 Jan 3. EBioMedicine. 2020. PMID: 31911274 Free PMC article.
BACKGROUND: A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but the underlying mechanisms remain elusive. ...METHODS: Neonatal and adult rat ventricular myocytes were used to overexpress MEF2C …
BACKGROUND: A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but …
Desmin deficiency affects the microenvironment of the cardiac side population and Sca1(+) stem cell population of the adult heart and impairs their cardiomyogenic commitment.
Nikouli S, Tsikitis M, Raftopoulou C, Gagos S, Psarras S, Capetanaki Y. Nikouli S, et al. Cell Tissue Res. 2022 Aug;389(2):309-326. doi: 10.1007/s00441-022-03643-8. Epub 2022 Jun 4. Cell Tissue Res. 2022. PMID: 35661920
The heart's limited regenerative capacity raises the need for novel stem cell-based therapeutic approaches for cardiac regeneration. ...Specifically, we found that mRNA levels of the cardiac transcription factors Mef2c and Nkx2.5 were significantly reduced in …
The heart's limited regenerative capacity raises the need for novel stem cell-based therapeutic approaches for cardiac regener …
Direct reprogramming as a route to cardiac repair.
Garry GA, Bassel-Duby R, Olson EN. Garry GA, et al. Semin Cell Dev Biol. 2022 Feb;122:3-13. doi: 10.1016/j.semcdb.2021.05.019. Epub 2021 Jul 8. Semin Cell Dev Biol. 2022. PMID: 34246567 Free PMC article. Review.
Ischemic heart disease is the leading cause of morbidity, mortality, and healthcare expenditure worldwide due to an inability of the heart to regenerate following injury. Thus, novel heart failure therapies aimed at promoting cardiomyocyte regeneration are de …
Ischemic heart disease is the leading cause of morbidity, mortality, and healthcare expenditure worldwide due to an inability of the …
Mef2c- and Nkx2-5-Divergent Transcriptional Regulation of Chick WT1_76127 and Mouse Gm14014 lncRNAs and Their Implication in Epicardial Cell Migration.
Caño-Carrillo S, Garcia-Padilla C, Aranega AE, Lozano-Velasco E, Franco D. Caño-Carrillo S, et al. Int J Mol Sci. 2024 Nov 30;25(23):12904. doi: 10.3390/ijms252312904. Int J Mol Sci. 2024. PMID: 39684625 Free PMC article.
Soon after rightward looping, the embryonic heart becomes externally covered by a new epithelial lining, the embryonic epicardium. ...We demonstrated that Wt1_76127 in chicken and its putative conserved homologue Gm14014 in mice are widely distributed in different embryoni …
Soon after rightward looping, the embryonic heart becomes externally covered by a new epithelial lining, the embryonic epicardium. .. …
The transcription factor MEF2A fine-tunes gene expression in the atrial and ventricular chambers of the adult heart.
Medrano JL, Naya FJ. Medrano JL, et al. J Biol Chem. 2017 Dec 22;292(51):20975-20988. doi: 10.1074/jbc.M117.806422. Epub 2017 Oct 20. J Biol Chem. 2017. PMID: 29054930 Free PMC article.
Although a number of transcription factors have been identified for proper gene regulation in the chambers, the complete transcriptional network that controls these patterns remains poorly defined. Previous studies have implicated the MEF2C transcription factor in the regu …
Although a number of transcription factors have been identified for proper gene regulation in the chambers, the complete transcriptional net …
Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development.
Leonard R, Zhao Y, Eliason S, Zimmerman K, Batz A, Hatcher CJ, Weiss RM, Sweat M, Li X, Amendt BA. Leonard R, et al. Nat Commun. 2025 Jul 29;16(1):6947. doi: 10.1038/s41467-025-62208-9. Nat Commun. 2025. PMID: 40721580 Free PMC article.
Transcription factors such as Tbx5, Gata4, Mef2c and Pitx2 are required during cardiac development, and in adult cardiac homeostasis. ...In this report, we identify several transcription factors regulated by miR-200 during heart development, a role for miR-20 …
Transcription factors such as Tbx5, Gata4, Mef2c and Pitx2 are required during cardiac development, and in adult cardiac homeo …
Discovery and progress of direct cardiac reprogramming.
Kojima H, Ieda M. Kojima H, et al. Cell Mol Life Sci. 2017 Jun;74(12):2203-2215. doi: 10.1007/s00018-017-2466-4. Epub 2017 Feb 14. Cell Mol Life Sci. 2017. PMID: 28197667 Free PMC article. Review.
We first reported a combination of cardiac-specific transcription factors, Gata4, Mef2c, and Tbx5 (GMT), that could convert mouse fibroblasts into cardiomyocyte-like cells, which were designated as induced cardiomyocyte-like cells (iCMs). Following our first report of card …
We first reported a combination of cardiac-specific transcription factors, Gata4, Mef2c, and Tbx5 (GMT), that could convert mouse fib …
137 results