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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1996 1
1998 1
1999 3
2001 1
2002 4
2003 1
2004 3
2005 1
2006 2
2007 4
2008 1
2009 4
2010 6
2011 4
2012 14
2013 11
2014 11
2015 9
2016 12
2017 12
2018 2
2019 11
2020 11
2021 11
2022 3
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125 results
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Page 1
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Xin M, Olson EN, Bassel-Duby R. Xin M, et al. Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10. Nat Rev Mol Cell Biol. 2013. PMID: 23839576 Free PMC article. Review.
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and disease can result in heart failure and death. The cellular processes and regulatory mechanisms involved in heart growth and de …
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and d …
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. Song K, et al. Nature. 2012 May 13;485(7400):599-604. doi: 10.1038/nature11139. Nature. 2012. PMID: 22660318 Free PMC article.
The adult mammalian heart possesses little regenerative potential following injury. ...Here we show that four transcription factors, GATA4, HAND2, MEF2C and TBX5, can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating car …
The adult mammalian heart possesses little regenerative potential following injury. ...Here we show that four transcription fa …
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.
Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. Qian L, et al. Nature. 2012 May 31;485(7400):593-8. doi: 10.1038/nature11044. Nature. 2012. PMID: 22522929 Free PMC article.
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for regenerative medicine. We reported previously that cardiac fibroblasts,which represent 50%of the cells in the mammalian heart, can be …
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for …
The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming.
Garry GA, Bezprozvannaya S, Chen K, Zhou H, Hashimoto H, Morales MG, Liu N, Bassel-Duby R, Olson EN. Garry GA, et al. Nat Cell Biol. 2021 May;23(5):467-475. doi: 10.1038/s41556-021-00668-z. Epub 2021 May 3. Nat Cell Biol. 2021. PMID: 33941892 Free PMC article.
Cardiac reprogramming was initially achieved through overexpression of the transcription factors Gata4, Mef2c and Tbx5; later, Hand2 and Akt1 were found to further enhance this process(1-5). Yet, staunch epigenetic barriers severely limit the ability of these cocktails to …
Cardiac reprogramming was initially achieved through overexpression of the transcription factors Gata4, Mef2c and Tbx5; later, Hand2 …
MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure.
Pereira AHM, Cardoso AC, Consonni SR, Oliveira RR, Saito A, Vaggione MLB, Matos-Souza JR, Carazzolle MF, Gonçalves A, Fernandes JL, Ribeiro GCA, Lopes MM, Molkentin JD, Franchini KG. Pereira AHM, et al. EBioMedicine. 2020 Jan;51:102571. doi: 10.1016/j.ebiom.2019.11.032. Epub 2020 Jan 3. EBioMedicine. 2020. PMID: 31911274 Free PMC article.
BACKGROUND: A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but the underlying mechanisms remain elusive. ...METHODS: Neonatal and adult rat ventricular myocytes were used to overexpress MEF2C
BACKGROUND: A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but …
Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury.
Zhao H, Zhang Y, Xu X, Sun Q, Yang C, Wang H, Yang J, Yang Y, Yang X, Liu Y, Zhao Y. Zhao H, et al. Front Cell Dev Biol. 2021 Feb 26;9:608367. doi: 10.3389/fcell.2021.608367. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33718351 Free PMC article.
Direct conversion of fibroblasts into induced cardiomyocytes (iCMs) holds promising potential to generate functional cardiomyocytes for drug development and clinical applications, especially for direct in situ heart regeneration by delivery of reprogramming genes into a
Direct conversion of fibroblasts into induced cardiomyocytes (iCMs) holds promising potential to generate functional cardiomyocytes for drug …
Interactivity of biochemical and physical stimuli during epigenetic conditioning and cardiomyocytic differentiation of stem and progenitor cells derived from adult hearts.
Zeng WR, Doran PM. Zeng WR, et al. Integr Biol (Camb). 2021 Mar 17;13(3):73-85. doi: 10.1093/intbio/zyab003. Integr Biol (Camb). 2021. PMID: 33704437
Mixed populations of cardiosphere-derived stem and progenitor cells containing proliferative and cardiomyogenically committed cells were obtained from adult rat hearts. The cells were cultured in either static 2D monolayers or dynamic 3D scaffold systems with fluid …
Mixed populations of cardiosphere-derived stem and progenitor cells containing proliferative and cardiomyogenically committed cells were obt …
MiR-21, MiR-29a, GATA4, and MEF2c Expression Changes in Endothelin-1 and Angiotensin II Cardiac Hypertrophy Stimulated Isl-1+Sca-1+c-kit+ Porcine Cardiac Progenitor Cells In Vitro.
Zlabinger K, Spannbauer A, Traxler D, Gugerell A, Lukovic D, Winkler J, Mester-Tonczar J, Podesser B, Gyöngyösi M. Zlabinger K, et al. Cells. 2019 Nov 9;8(11):1416. doi: 10.3390/cells8111416. Cells. 2019. PMID: 31717562 Free PMC article.
Cost- and time-intensive porcine translational disease models offer great opportunities to test drugs and therapies for pathological cardiac hypertrophy and can be supported by porcine cell culture models that provide further insights into basic disease mechanisms. Cardiac progen …
Cost- and time-intensive porcine translational disease models offer great opportunities to test drugs and therapies for pathological cardiac …
Effects of aerobic and inspiratory training on skeletal muscle microRNA-1 and downstream-associated pathways in patients with heart failure.
Antunes-Correa LM, Trevizan PF, Bacurau AVN, Ferreira-Santos L, Gomes JLP, Urias U, Oliveira PA, Alves MJNN, de Almeida DR, Brum PC, Oliveira EM, Hajjar L, Kalil Filho R, Negrão CE. Antunes-Correa LM, et al. J Cachexia Sarcopenia Muscle. 2020 Feb;11(1):89-102. doi: 10.1002/jcsm.12495. Epub 2019 Nov 19. J Cachexia Sarcopenia Muscle. 2020. PMID: 31743617 Free PMC article.
BACKGROUND: The exercise intolerance in chronic heart failure with reduced ejection fraction (HFrEF) is mostly attributed to alterations in skeletal muscle. ...The increased levels of microRNA-1 also decreased HDAC4 and increased MEF2c, MyoD, and follistatin express …
BACKGROUND: The exercise intolerance in chronic heart failure with reduced ejection fraction (HFrEF) is mostly attributed to alterati …
Key Regulators of Cardiovascular Differentiation and Regeneration: Harnessing the Potential of Direct Reprogramming to Treat Heart Failure.
Ieda M. Ieda M. J Card Fail. 2020 Jan;26(1):80-84. doi: 10.1016/j.cardfail.2019.09.005. Epub 2019 Sep 18. J Card Fail. 2020. PMID: 31541743 Review.
Cardiovascular diseases remain a leading cause of death worldwide, with the number of patients with heart failure increasing rapidly in aging societies. As adult cardiomyocytes are terminally differentiated cells and opportunities for heart transplantation ar …
Cardiovascular diseases remain a leading cause of death worldwide, with the number of patients with heart failure increasing rapidly …
125 results