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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1996 1
1998 1
1999 3
2001 1
2002 4
2003 1
2004 3
2005 1
2006 2
2007 4
2008 1
2009 4
2010 6
2011 4
2012 14
2013 11
2014 11
2015 9
2016 12
2017 12
2018 2
2019 11
2020 11
2021 11
2022 5
2023 3
2024 0

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129 results

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Page 1
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Xin M, Olson EN, Bassel-Duby R. Xin M, et al. Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10. Nat Rev Mol Cell Biol. 2013. PMID: 23839576 Free PMC article. Review.
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and disease can result in heart failure and death. The cellular processes and regulatory mechanisms involved in heart growth and de …
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and d …
Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction.
Tani H, Sadahiro T, Yamada Y, Isomi M, Yamakawa H, Fujita R, Abe Y, Akiyama T, Nakano K, Kuze Y, Seki M, Suzuki Y, Fujisawa M, Sakata-Yanagimoto M, Chiba S, Fukuda K, Ieda M. Tani H, et al. Circulation. 2023 Jan 17;147(3):223-238. doi: 10.1161/CIRCULATIONAHA.121.058655. Epub 2022 Dec 12. Circulation. 2023. PMID: 36503256
BACKGROUND: Because adult cardiomyocytes have little regenerative capacity, resident cardiac fibroblasts (CFs) synthesize extracellular matrix after myocardial infarction (MI) to form fibrosis, leading to cardiac dysfunction and heart failure. ...These findings pres …
BACKGROUND: Because adult cardiomyocytes have little regenerative capacity, resident cardiac fibroblasts (CFs) synthesize extracellul …
TBX20 Improves Contractility and Mitochondrial Function During Direct Human Cardiac Reprogramming.
Tang Y, Aryal S, Geng X, Zhou X, Fast VG, Zhang J, Lu R, Zhou Y. Tang Y, et al. Circulation. 2022 Nov 15;146(20):1518-1536. doi: 10.1161/CIRCULATIONAHA.122.059713. Epub 2022 Sep 14. Circulation. 2022. PMID: 36102189 Free PMC article.
RESULTS: We identified TBX20 (T-box transcription factor 20) as the top cardiac gene that is unable to be activated by the MGT133 reprogramming cocktail (MEF2C, GATA4, TBX5, and miR-133). TBX20 is required for normal heart development and cardiac function in adul
RESULTS: We identified TBX20 (T-box transcription factor 20) as the top cardiac gene that is unable to be activated by the MGT133 reprogramm …
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.
Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. Qian L, et al. Nature. 2012 May 31;485(7400):593-8. doi: 10.1038/nature11044. Nature. 2012. PMID: 22522929 Free PMC article.
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for regenerative medicine. We reported previously that cardiac fibroblasts,which represent 50%of the cells in the mammalian heart, can be …
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for …
MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure.
Pereira AHM, Cardoso AC, Consonni SR, Oliveira RR, Saito A, Vaggione MLB, Matos-Souza JR, Carazzolle MF, Gonçalves A, Fernandes JL, Ribeiro GCA, Lopes MM, Molkentin JD, Franchini KG. Pereira AHM, et al. EBioMedicine. 2020 Jan;51:102571. doi: 10.1016/j.ebiom.2019.11.032. Epub 2020 Jan 3. EBioMedicine. 2020. PMID: 31911274 Free PMC article.
BACKGROUND: A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but the underlying mechanisms remain elusive. ...METHODS: Neonatal and adult rat ventricular myocytes were used to overexpress MEF2C
BACKGROUND: A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but …
Desmin deficiency affects the microenvironment of the cardiac side population and Sca1(+) stem cell population of the adult heart and impairs their cardiomyogenic commitment.
Nikouli S, Tsikitis M, Raftopoulou C, Gagos S, Psarras S, Capetanaki Y. Nikouli S, et al. Cell Tissue Res. 2022 Aug;389(2):309-326. doi: 10.1007/s00441-022-03643-8. Epub 2022 Jun 4. Cell Tissue Res. 2022. PMID: 35661920
The heart's limited regenerative capacity raises the need for novel stem cell-based therapeutic approaches for cardiac regeneration. ...Specifically, we found that mRNA levels of the cardiac transcription factors Mef2c and Nkx2.5 were significantly reduced in …
The heart's limited regenerative capacity raises the need for novel stem cell-based therapeutic approaches for cardiac regener …
Direct reprogramming as a route to cardiac repair.
Garry GA, Bassel-Duby R, Olson EN. Garry GA, et al. Semin Cell Dev Biol. 2022 Feb;122:3-13. doi: 10.1016/j.semcdb.2021.05.019. Epub 2021 Jul 8. Semin Cell Dev Biol. 2022. PMID: 34246567 Free PMC article. Review.
Ischemic heart disease is the leading cause of morbidity, mortality, and healthcare expenditure worldwide due to an inability of the heart to regenerate following injury. Thus, novel heart failure therapies aimed at promoting cardiomyocyte regeneration are de …
Ischemic heart disease is the leading cause of morbidity, mortality, and healthcare expenditure worldwide due to an inability of the …
Discovery and progress of direct cardiac reprogramming.
Kojima H, Ieda M. Kojima H, et al. Cell Mol Life Sci. 2017 Jun;74(12):2203-2215. doi: 10.1007/s00018-017-2466-4. Epub 2017 Feb 14. Cell Mol Life Sci. 2017. PMID: 28197667 Review.
We first reported a combination of cardiac-specific transcription factors, Gata4, Mef2c, and Tbx5 (GMT), that could convert mouse fibroblasts into cardiomyocyte-like cells, which were designated as induced cardiomyocyte-like cells (iCMs). Following our first report of card …
We first reported a combination of cardiac-specific transcription factors, Gata4, Mef2c, and Tbx5 (GMT), that could convert mouse fib …
Differential chamber-specific expression and regulation of long non-coding RNAs during cardiac development.
García-Padilla C, Domínguez JN, Aránega AE, Franco D. García-Padilla C, et al. Biochim Biophys Acta Gene Regul Mech. 2019 Oct;1862(10):194435. doi: 10.1016/j.bbagrm.2019.194435. Epub 2019 Nov 1. Biochim Biophys Acta Gene Regul Mech. 2019. PMID: 31678627 Review.
In this study, we investigated the differential expression profile during cardiogenesis of previously reported lncRNAs in heart development. Our data revealed that Braveheart, Fendrr, Carmen display a preferential adult expression while Miat, Alien, H19 preferential …
In this study, we investigated the differential expression profile during cardiogenesis of previously reported lncRNAs in heart devel …
Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury.
Zhao H, Zhang Y, Xu X, Sun Q, Yang C, Wang H, Yang J, Yang Y, Yang X, Liu Y, Zhao Y. Zhao H, et al. Front Cell Dev Biol. 2021 Feb 26;9:608367. doi: 10.3389/fcell.2021.608367. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33718351 Free PMC article.
Direct conversion of fibroblasts into induced cardiomyocytes (iCMs) holds promising potential to generate functional cardiomyocytes for drug development and clinical applications, especially for direct in situ heart regeneration by delivery of reprogramming genes into a
Direct conversion of fibroblasts into induced cardiomyocytes (iCMs) holds promising potential to generate functional cardiomyocytes for drug …
129 results