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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1996 1
1998 1
1999 3
2001 1
2002 4
2003 1
2004 3
2005 1
2006 2
2007 4
2008 1
2009 4
2010 6
2011 4
2012 14
2013 11
2014 11
2015 9
2016 12
2017 12
2018 2
2019 10
2020 7
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110 results
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Page 1
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Xin M, Olson EN, Bassel-Duby R. Xin M, et al. Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10. Nat Rev Mol Cell Biol. 2013. PMID: 23839576 Free PMC article. Review.
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and disease can result in heart failure and death. The cellular processes and regulatory mechanisms involved in heart growth and de …
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and d …
Key Regulators of Cardiovascular Differentiation and Regeneration: Harnessing the Potential of Direct Reprogramming to Treat Heart Failure.
Ieda M. Ieda M. J Card Fail. 2020 Jan;26(1):80-84. doi: 10.1016/j.cardfail.2019.09.005. Epub 2019 Sep 18. J Card Fail. 2020. PMID: 31541743 Review.
As adult cardiomyocytes are terminally differentiated cells and opportunities for heart transplantation are very limited, regenerative medicine may become a game changer in heart failure treatment. ...Fibroblasts can be directly reprogrammed into cardiomyocyt …
As adult cardiomyocytes are terminally differentiated cells and opportunities for heart transplantation are very limited, rege …
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. Song K, et al. Nature. 2012 May 13;485(7400):599-604. doi: 10.1038/nature11139. Nature. 2012. PMID: 22660318 Free PMC article.
The adult mammalian heart possesses little regenerative potential following injury. Fibrosis due to activation of cardiac fibroblasts impedes cardiac regeneration and contributes to loss of contractile function, pathological remodelling and susceptibility to arrhyth …
The adult mammalian heart possesses little regenerative potential following injury. Fibrosis due to activation of cardiac fibr …
MiR-21, MiR-29a, GATA4, and MEF2c Expression Changes in Endothelin-1 and Angiotensin II Cardiac Hypertrophy Stimulated Isl-1(+)Sca-1(+)c-kit(+) Porcine Cardiac Progenitor Cells In Vitro.
Zlabinger K, Spannbauer A, Traxler D, Gugerell A, Lukovic D, Winkler J, Mester-Tonczar J, Podesser B, Gyöngyösi M. Zlabinger K, et al. Cells. 2019 Nov 9;8(11):1416. doi: 10.3390/cells8111416. Cells. 2019. PMID: 31717562 Free PMC article.
Cardiac progenitor cells (CPCs) residing in the adult heart have been shown to differentiate in vitro into cardiomyocytes and could contribute to cardiac regeneration. ...We successfully isolated Isl1(+)Sca1(+)cKit(+) porcine CPCs (pCPCs) from pig hearts and …
Cardiac progenitor cells (CPCs) residing in the adult heart have been shown to differentiate in vitro into cardiomyocytes and …
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.
Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. Qian L, et al. Nature. 2012 May 31;485(7400):593-8. doi: 10.1038/nature11044. Nature. 2012. PMID: 22522929 Free PMC article.
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for regenerative medicine. We reported previously that cardiac fibroblasts,which represent 50%of the cells in the mammalian heart, can be …
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for …
Histone Methyltransferase G9a Is Required for Cardiomyocyte Homeostasis and Hypertrophy.
Papait R, Serio S, Pagiatakis C, Rusconi F, Carullo P, Mazzola M, Salvarani N, Miragoli M, Condorelli G. Papait R, et al. Circulation. 2017 Sep 26;136(13):1233-1246. doi: 10.1161/CIRCULATIONAHA.117.028561. Epub 2017 Aug 4. Circulation. 2017. PMID: 28778944
Although the role of some histone methyltransferases in establishing the transcriptional program of postnatal cardiomyocytes during heart development has been shown, the function of this class of epigenetic enzymes is largely unexplored in the adult heart. .. …
Although the role of some histone methyltransferases in establishing the transcriptional program of postnatal cardiomyocytes during heart
A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers.
Akerberg BN, Gu F, VanDusen NJ, Zhang X, Dong R, Li K, Zhang B, Zhou B, Sethi I, Ma Q, Wasson L, Wen T, Liu J, Dong K, Conlon FL, Zhou J, Yuan GC, Zhou P, Pu WT. Akerberg BN, et al. Nat Commun. 2019 Oct 28;10(1):4907. doi: 10.1038/s41467-019-12812-3. Nat Commun. 2019. PMID: 31659164 Free PMC article.
Here we use biotinylated knockin alleles of seven key cardiac TFs (GATA4, NKX2-5, MEF2A, MEF2C, SRF, TBX5, TEAD1) to sensitively and reproducibly map their genome-wide occupancy in the fetal and adult mouse heart. ...Our study provides a resource for decipher …
Here we use biotinylated knockin alleles of seven key cardiac TFs (GATA4, NKX2-5, MEF2A, MEF2C, SRF, TBX5, TEAD1) to sensitively and …
Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming.
Muraoka N, Nara K, Tamura F, Kojima H, Yamakawa H, Sadahiro T, Miyamoto K, Isomi M, Haginiwa S, Tani H, Kurotsu S, Osakabe R, Torii S, Shimizu S, Okano H, Sugimoto Y, Fukuda K, Ieda M. Muraoka N, et al. Nat Commun. 2019 Feb 20;10(1):674. doi: 10.1038/s41467-019-08626-y. Nat Commun. 2019. PMID: 30787297 Free PMC article.
Direct cardiac reprogramming from fibroblasts can be a promising approach for disease modeling, drug screening, and cardiac regeneration in pediatric and adult patients. ...In this study, we screened 8400 chemical compounds and found that diclofenac sodium (diclofenac), a …
Direct cardiac reprogramming from fibroblasts can be a promising approach for disease modeling, drug screening, and cardiac regeneration in …
Vascular Endothelial Growth Factor and Ischemic Heart Disease Risk: A Mendelian Randomization Study.
Au Yeung SL, Lam HSHS, Schooling CM. Au Yeung SL, et al. J Am Heart Assoc. 2017 Aug 1;6(8):e005619. doi: 10.1161/JAHA.117.005619. J Am Heart Assoc. 2017. PMID: 28765276 Free PMC article.
We assessed ischemic heart disease (IHD) risk by genetically predicted VEGF, ie, using Mendelian randomization. METHODS AND RESULTS: Single nucleotide polymorphisms (SNPs) predicting VEGF level, at genome-wide significance, were applied to the CARDIoGRAMplusC4D 1000 Genome …
We assessed ischemic heart disease (IHD) risk by genetically predicted VEGF, ie, using Mendelian randomization. METHODS AND RESULTS: …
MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure.
Pereira AHM, Cardoso AC, Consonni SR, Oliveira RR, Saito A, Vaggione MLB, Matos-Souza JR, Carazzolle MF, Gonçalves A, Fernandes JL, Ribeiro GCA, Lopes MM, Molkentin JD, Franchini KG. Pereira AHM, et al. EBioMedicine. 2020 Jan;51:102571. doi: 10.1016/j.ebiom.2019.11.032. Epub 2020 Jan 3. EBioMedicine. 2020. PMID: 31911274 Free PMC article.
BACKGROUND: A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but the underlying mechanisms remain elusive. ...METHODS: Neonatal and adult rat ventricular myocytes were used to overexpress MEF2C
BACKGROUND: A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but …
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