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270 results

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Page 1
Meis2 controls skeletal formation in the hyoid region.
Fabik J, Psutkova V, Machon O. Fabik J, et al. Front Cell Dev Biol. 2022 Sep 28;10:951063. doi: 10.3389/fcell.2022.951063. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36247013 Free PMC article.
Here, we present a model of the hyoid apparatus development in Wnt1-Cre2-induced Meis2 conditional knock-out (cKO) mice. Meis2 cKO embryos develop an aberrant hyoid apparatus-a complete skeletal chain from the base of the neurocranium to lesser horns of the hyoid, r …
Here, we present a model of the hyoid apparatus development in Wnt1-Cre2-induced Meis2 conditional knock-out (cKO) mice. Meis2 …
MEIS2 suppresses breast cancer development by downregulating IL10.
Xiao Y, Liu Y, Sun Y, Huang C, Zhong S. Xiao Y, et al. Cancer Rep (Hoboken). 2024 May;7(5):e2064. doi: 10.1002/cnr2.2064. Cancer Rep (Hoboken). 2024. PMID: 38711262 Free PMC article.
The expression of MEIS2 is inversely correlated with BC clinical stages and pathological grades. MEIS2 knockdown (MEIS2-KD) promotes while MEIS2 overexpression suppresses breast cancer cell proliferation and tumor development in vitro and in animal xen …
The expression of MEIS2 is inversely correlated with BC clinical stages and pathological grades. MEIS2 knockdown (MEIS2 …
MEIS2 promotes cell migration and invasion in colorectal cancer.
Wan Z, Chai R, Yuan H, Chen B, Dong Q, Zheng B, Mou X, Pan W, Tu Y, Yang Q, Tu S, Hu X. Wan Z, et al. Oncol Rep. 2019 Jul;42(1):213-223. doi: 10.3892/or.2019.7161. Epub 2019 May 15. Oncol Rep. 2019. PMID: 31115559 Free PMC article.
Distant metastasis is a key cause of CRC-associated mortality. MEIS2 has been identified to be dysregulated in several types of human cancer. However, the mechanisms underlying the regulatory role of MEIS2 in CRC metastasis remain largely unknown. ...The present stu …
Distant metastasis is a key cause of CRC-associated mortality. MEIS2 has been identified to be dysregulated in several types of human …
Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum.
Su Z, Wang Z, Lindtner S, Yang L, Shang Z, Tian Y, Guo R, You Y, Zhou W, Rubenstein JL, Yang Z, Zhang Z. Su Z, et al. Development. 2022 Feb 15;149(4):dev200035. doi: 10.1242/dev.200035. Epub 2022 Feb 23. Development. 2022. PMID: 35156680 Free PMC article.
Meis2 directly binds to the Zfp503 and Six3 promoters and is required for their expression and specification of D1 and D2 MSNs, respectively. Finally, Meis2 expression is regulated by Dlx1/2 at least partially through the enhancer hs599 in the LGE subventricular zon …
Meis2 directly binds to the Zfp503 and Six3 promoters and is required for their expression and specification of D1 and D2 MSNs, respe …
Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea.
Durán Alonso MB, Vendrell V, López-Hernández I, Alonso MT, Martin DM, Giráldez F, Carramolino L, Giovinazzo G, Vázquez E, Torres M, Schimmang T. Durán Alonso MB, et al. Front Cell Dev Biol. 2021 May 28;9:679325. doi: 10.3389/fcell.2021.679325. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34124068 Free PMC article.
Global inactivation of Meis2 in the mouse leads to a severely reduced size of the otic vesicle. Tissue-specific knock outs of Meis2 reveal that its expression in the hindbrain is essential for otic vesicle formation. Inactivation of Meis2 in the inner ear its …
Global inactivation of Meis2 in the mouse leads to a severely reduced size of the otic vesicle. Tissue-specific knock outs of Meis …
The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice.
Wang L, Tang Q, Xu J, Li H, Yang T, Li L, Machon O, Hu T, Chen Y. Wang L, et al. J Biol Chem. 2020 Apr 17;295(16):5449-5460. doi: 10.1074/jbc.RA120.012684. Epub 2020 Mar 13. J Biol Chem. 2020. PMID: 32169905 Free PMC article.
Haploinsufficiency of Meis homeobox 2 (MEIS2), encoding a transcriptional regulator, is associated with human cleft palate, and Meis2 inactivation leads to abnormal palate development in mice, implicating MEIS2 functions in palate development. ...However, alt …
Haploinsufficiency of Meis homeobox 2 (MEIS2), encoding a transcriptional regulator, is associated with human cleft palate, and Me …
De novo MEIS2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux.
Fujita A, Isidor B, Piloquet H, Corre P, Okamoto N, Nakashima M, Tsurusaki Y, Saitsu H, Miyake N, Matsumoto N. Fujita A, et al. J Hum Genet. 2016 Sep;61(9):835-8. doi: 10.1038/jhg.2016.54. Epub 2016 May 26. J Hum Genet. 2016. PMID: 27225850 Review.
MEIS2 aberrations are considered to be the cause of intellectual disability, cleft palate and cardiac septal defect, as MEIS2 copy number variation is often observed with these phenotypes. To our knowledge, only one nucleotide-level change-specifically, an in-frame …
MEIS2 aberrations are considered to be the cause of intellectual disability, cleft palate and cardiac septal defect, as MEIS2 …
Epigenetic silencing of MEIS2 in prostate cancer recurrence.
Nørgaard M, Haldrup C, Bjerre MT, Høyer S, Ulhøi B, Borre M, Sørensen KD. Nørgaard M, et al. Clin Epigenetics. 2019 Oct 22;11(1):147. doi: 10.1186/s13148-019-0742-x. Clin Epigenetics. 2019. PMID: 31640805 Free PMC article.
Moreover, in this cohort, aberrant MEIS2 hypermethylation was significantly associated with post-operative BCR (p = 0.0068, log-rank test), which was subsequently confirmed (p = 0.0067; log-rank test) in the independent TCGA validation cohort (497 RP patients; 450K data). …
Moreover, in this cohort, aberrant MEIS2 hypermethylation was significantly associated with post-operative BCR (p = 0.0068, log-rank …
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH. Fischer ES, et al. Nature. 2014 Aug 7;512(7512):49-53. doi: 10.1038/nature13527. Epub 2014 Jul 16. Nature. 2014. PMID: 25043012 Free PMC article.
Using an unbiased screen, we identified the homeobox transcription factor MEIS2 as an endogenous substrate of CRL4(CRBN). Our studies suggest that IMiDs block endogenous substrates (MEIS2) from binding to CRL4(CRBN) while the ligase complex is recruiting IKZF1 or IK …
Using an unbiased screen, we identified the homeobox transcription factor MEIS2 as an endogenous substrate of CRL4(CRBN). Our studies …
MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AML.
Vegi NM, Klappacher J, Oswald F, Mulaw MA, Mandoli A, Thiel VN, Bamezai S, Feder K, Martens JHA, Rawat VPS, Mandal T, Quintanilla-Martinez L, Spiekermann K, Hiddemann W, Döhner K, Döhner H, Stunnenberg HG, Feuring-Buske M, Buske C. Vegi NM, et al. Cell Rep. 2016 Jul 12;16(2):498-507. doi: 10.1016/j.celrep.2016.05.094. Epub 2016 Jun 23. Cell Rep. 2016. PMID: 27346355 Free article.
Although the TALE family homeodomain factor Meis1 has been linked to malignancy, a role for MEIS2 is less clear. Here, we demonstrate that MEIS2 is expressed at high levels in patients with AML1-ETO-positive acute myeloid leukemia and that growth of AML1-ETO-positiv …
Although the TALE family homeodomain factor Meis1 has been linked to malignancy, a role for MEIS2 is less clear. Here, we demonstrate …
270 results