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308 results

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Page 1
MEIS2 suppresses breast cancer development by downregulating IL10.
Xiao Y, Liu Y, Sun Y, Huang C, Zhong S. Xiao Y, et al. Cancer Rep (Hoboken). 2024 May;7(5):e2064. doi: 10.1002/cnr2.2064. Cancer Rep (Hoboken). 2024. PMID: 38711262 Free PMC article.
The expression of MEIS2 is inversely correlated with BC clinical stages and pathological grades. MEIS2 knockdown (MEIS2-KD) promotes while MEIS2 overexpression suppresses breast cancer cell proliferation and tumor development in vitro and in animal xen …
The expression of MEIS2 is inversely correlated with BC clinical stages and pathological grades. MEIS2 knockdown (MEIS2 …
Meis2 controls skeletal formation in the hyoid region.
Fabik J, Psutkova V, Machon O. Fabik J, et al. Front Cell Dev Biol. 2022 Sep 28;10:951063. doi: 10.3389/fcell.2022.951063. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36247013 Free PMC article.
Here, we present a model of the hyoid apparatus development in Wnt1-Cre2-induced Meis2 conditional knock-out (cKO) mice. Meis2 cKO embryos develop an aberrant hyoid apparatus-a complete skeletal chain from the base of the neurocranium to lesser horns of the hyoid, r …
Here, we present a model of the hyoid apparatus development in Wnt1-Cre2-induced Meis2 conditional knock-out (cKO) mice. Meis2 …
MEIS2 promotes cell migration and invasion in colorectal cancer.
Wan Z, Chai R, Yuan H, Chen B, Dong Q, Zheng B, Mou X, Pan W, Tu Y, Yang Q, Tu S, Hu X. Wan Z, et al. Oncol Rep. 2019 Jul;42(1):213-223. doi: 10.3892/or.2019.7161. Epub 2019 May 15. Oncol Rep. 2019. PMID: 31115559 Free PMC article.
Distant metastasis is a key cause of CRC-associated mortality. MEIS2 has been identified to be dysregulated in several types of human cancer. However, the mechanisms underlying the regulatory role of MEIS2 in CRC metastasis remain largely unknown. ...The present stu …
Distant metastasis is a key cause of CRC-associated mortality. MEIS2 has been identified to be dysregulated in several types of human …
De novo MEIS2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux.
Fujita A, Isidor B, Piloquet H, Corre P, Okamoto N, Nakashima M, Tsurusaki Y, Saitsu H, Miyake N, Matsumoto N. Fujita A, et al. J Hum Genet. 2016 Sep;61(9):835-8. doi: 10.1038/jhg.2016.54. Epub 2016 May 26. J Hum Genet. 2016. PMID: 27225850 Review.
MEIS2 aberrations are considered to be the cause of intellectual disability, cleft palate and cardiac septal defect, as MEIS2 copy number variation is often observed with these phenotypes. To our knowledge, only one nucleotide-level change-specifically, an in-frame …
MEIS2 aberrations are considered to be the cause of intellectual disability, cleft palate and cardiac septal defect, as MEIS2 …
The neuronal transcription factor MEIS2 is a calpain-2 protease target.
Müller T, Reichlmeir M, Hau AC, Wittig I, Schulte D. Müller T, et al. J Cell Sci. 2024 Feb 15;137(4):jcs261482. doi: 10.1242/jcs.261482. Epub 2024 Feb 28. J Cell Sci. 2024. PMID: 38305737 Free PMC article.
We here identify MEIS2 as direct target of the intracellular protease calpain-2 (composed of the catalytic subunit CAPN2 and the regulatory subunit CAPNS1). Phosphorylation at conserved serine and/or threonine residues, or dimerization with PBX1, reduced the sensitivity of …
We here identify MEIS2 as direct target of the intracellular protease calpain-2 (composed of the catalytic subunit CAPN2 and the regu …
Human Genetics of Ventricular Septal Defect.
Perrot A, Rickert-Sperling S. Perrot A, et al. Adv Exp Med Biol. 2024;1441:505-534. doi: 10.1007/978-3-031-44087-8_27. Adv Exp Med Biol. 2024. PMID: 38884729
The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice.
Wang L, Tang Q, Xu J, Li H, Yang T, Li L, Machon O, Hu T, Chen Y. Wang L, et al. J Biol Chem. 2020 Apr 17;295(16):5449-5460. doi: 10.1074/jbc.RA120.012684. Epub 2020 Mar 13. J Biol Chem. 2020. PMID: 32169905 Free PMC article.
Haploinsufficiency of Meis homeobox 2 (MEIS2), encoding a transcriptional regulator, is associated with human cleft palate, and Meis2 inactivation leads to abnormal palate development in mice, implicating MEIS2 functions in palate development. ...However, alt …
Haploinsufficiency of Meis homeobox 2 (MEIS2), encoding a transcriptional regulator, is associated with human cleft palate, and Me …
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH. Fischer ES, et al. Nature. 2014 Aug 7;512(7512):49-53. doi: 10.1038/nature13527. Epub 2014 Jul 16. Nature. 2014. PMID: 25043012 Free PMC article.
Using an unbiased screen, we identified the homeobox transcription factor MEIS2 as an endogenous substrate of CRL4(CRBN). Our studies suggest that IMiDs block endogenous substrates (MEIS2) from binding to CRL4(CRBN) while the ligase complex is recruiting IKZF1 or IK …
Using an unbiased screen, we identified the homeobox transcription factor MEIS2 as an endogenous substrate of CRL4(CRBN). Our studies …
Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation.
Kaplan MM, Hudacova E, Matejcek M, Tuaima H, Křivánek J, Machon O. Kaplan MM, et al. Elife. 2025 Apr 4;13:RP100854. doi: 10.7554/eLife.100854. Elife. 2025. PMID: 40183774 Free PMC article.
Using genetic approach in mice, we show that Meis2 expression in cells derived from the neural crest is critical for whisker formation and also for branching of trigeminal nerves. ...MEIS2 regulates the expression of transcription factor Foxd1, which is typical of p …
Using genetic approach in mice, we show that Meis2 expression in cells derived from the neural crest is critical for whisker formatio …
Meis2 represses the osteoblastic transdifferentiation of aortic valve interstitial cells through the Notch1/Twist1 pathway.
Sun C, Liu H, Si K, Wu Y, Zhao K, Xu R, Zhou Z, Zheng Z. Sun C, et al. Biochem Biophys Res Commun. 2019 Feb 5;509(2):455-461. doi: 10.1016/j.bbrc.2018.12.040. Epub 2018 Dec 26. Biochem Biophys Res Commun. 2019. PMID: 30594396
This study aims to elucidate the specific functions of Meis2 and its downstream targets in aortic valve calcification. MATERIAL AND METHODS: Levels of Meis2 were examined in calcified (n = 30) and normal (n = 30) human aortic valve tissues, respectively. ...The Resu …
This study aims to elucidate the specific functions of Meis2 and its downstream targets in aortic valve calcification. MATERIAL AND M …
308 results