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Pan-cancer analysis reveals potential immunological and prognostic roles of METTL7A in human cancers.
Wang B, Jiang J, Luo D, Wang X. Wang B, et al. Sci Rep. 2024 Feb 12;14(1):3476. doi: 10.1038/s41598-024-54255-x. Sci Rep. 2024. PMID: 38342956 Free PMC article.
Immunohistochemistry staining was applied to detect METTL7A in 6 tumors. METTL7A was significantly decreased in 19 cancers in TCGA including LUAD. ...Additionally, METTL7A showed similar correlation with immune therapy-related genes across cancers …
Immunohistochemistry staining was applied to detect METTL7A in 6 tumors. METTL7A was significantly decreased in 19 cancers …
Evidence Based on an Integrative Analysis of Multi-Omics Data on METTL7A as a Molecular Marker in Pan-Cancer.
Liu Z, Chen Y, Shen T. Liu Z, et al. Biomolecules. 2023 Jan 18;13(2):195. doi: 10.3390/biom13020195. Biomolecules. 2023. PMID: 36830565 Free PMC article.
This study provides a comprehensive assessment of METTL7A from a pan-cancer perspective using multi-omics data. The gene ontology enrichment analysis of METTL7A-binding proteins revealed a close association with methylation and lipid metabolism. We then explo …
This study provides a comprehensive assessment of METTL7A from a pan-cancer perspective using multi-omics data. The gene ontol …
METTLing in Stem Cell and Cancer Biology.
Tooley JG, Catlin JP, Tooley CES. Tooley JG, et al. Stem Cell Rev Rep. 2023 Jan;19(1):76-91. doi: 10.1007/s12015-022-10444-7. Epub 2022 Sep 12. Stem Cell Rev Rep. 2023. PMID: 36094754 Free PMC article. Review.
The most well characterized family members METTL3 and METTL14 dimerize to form an N(6)-methyladenosine (m(6)A) RNA methyltransferase with established roles in cancer progression. However, new mouse models indicate that METTL3/METTL14 are also important for embryonic stem c …
The most well characterized family members METTL3 and METTL14 dimerize to form an N(6)-methyladenosine (m(6)A) RNA methyltransferase with es …
The novel putative methyltransferase METTL7A as one prognostic biomarker potentially associated with immune infiltration in human renal cancer.
Yang Z, Zhang W, Li L, Hu N, Dong X, Chen Y, Cai W, Yin L, Liu F, Tang D, Dai Y. Yang Z, et al. Heliyon. 2023 Apr 11;9(4):e15371. doi: 10.1016/j.heliyon.2023.e15371. eCollection 2023 Apr. Heliyon. 2023. PMID: 37123902 Free PMC article.
Among urological cancers, renal cancer has the highest fatality rate. In a previous pan-cancer study of the METTL family, we observed a stronger association between the METTL family members and the risk of renal cancer compared to other cancers. …
Among urological cancers, renal cancer has the highest fatality rate. In a previous pan-cancer study of the METTL famil …
METTL7A as a New Candidate Biomarker in Gastric Cancer by Genomics and Data-Independent Acquisition Proteomic Analysis.
Li X, Gao X, Yu X, Zhou Z, Xiong D, Zhang X. Li X, et al. Clin Lab. 2025 Mar 1;71(3). doi: 10.7754/Clin.Lab.2024.240701. Clin Lab. 2025. PMID: 40066548
The cancer genome atlas (TCGA) analysis revealed an area under the receiver operating characteristic (ROC) curve (AUC) of 0.81, with METTL7A expression inversely correlated with age (p = 7.307e-05). ...CONCLUSIONS: METTL7A is a promising biomarker for early G …
The cancer genome atlas (TCGA) analysis revealed an area under the receiver operating characteristic (ROC) curve (AUC) of 0.81, with …
DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer.
Zhou S, Shen Y, Zheng M, Wang L, Che R, Hu W, Li P. Zhou S, et al. Oncotarget. 2017 May 23;8(21):34652-34660. doi: 10.18632/oncotarget.16147. Oncotarget. 2017. PMID: 28416772 Free PMC article.
In this study, we revealed that the methylation level of METTL7A, a seldom studied gene, was downregulated in thyroid cancer compared to normal thyroid cells in vivo and in vitro. ...Finally, we revealed that EZH2, a subunit of polycomb repressor complex 2, dominant …
In this study, we revealed that the methylation level of METTL7A, a seldom studied gene, was downregulated in thyroid cancer c …
Comprehensive analysis of the significance of METTL7A gene in the prognosis of lung adenocarcinoma.
Pan YQ, Xiao Y, Li Z, Tao L, Chen G, Zhu JF, Lv L, Liu JC, Qi JQ, Shao A. Pan YQ, et al. Front Oncol. 2022 Dec 23;12:1071100. doi: 10.3389/fonc.2022.1071100. eCollection 2022. Front Oncol. 2022. PMID: 36620541 Free PMC article.
BACKGROUND: The most common subtype of lung cancer, called lung adenocarcinoma (LUAD), is also the largest cause of cancer death in the world. ...A competing endogenous RNA network, also known as ceRNA, was established with the help of the Cytoscape program. RESULTS …
BACKGROUND: The most common subtype of lung cancer, called lung adenocarcinoma (LUAD), is also the largest cause of cancer dea …
Gastric Cancer Heterogeneity and Clinical Outcomes.
Sexton RE, Hallak MNA, Uddin MH, Diab M, Azmi AS. Sexton RE, et al. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820935477. doi: 10.1177/1533033820935477. Technol Cancer Res Treat. 2020. PMID: 32799763 Free PMC article.
In this report, using publicly available data sets and pathway analysis, we highlight the vast heterogeneity of gastric cancer by investigating genes found to be significantly perturbed. We found several upregulated genes in the diffuse gastric cancer subtypes share …
In this report, using publicly available data sets and pathway analysis, we highlight the vast heterogeneity of gastric cancer by inv …
Transcriptomic characterization revealed that METTL7A inhibits melanoma progression via the p53 signaling pathway and immunomodulatory pathway.
Zhang D, Zou T, Liu Q, Chen J, Xiao M, Zheng A, Zhang Z, Du F, Dai Y, Xiang S, Wu X, Li M, Chen Y, Zhao Y, Shen J, Chen G, Xiao Z. Zhang D, et al. PeerJ. 2023 Aug 2;11:e15799. doi: 10.7717/peerj.15799. eCollection 2023. PeerJ. 2023. PMID: 37547717 Free PMC article.
However, few research have been carried out to explore the relationship between METTL7A and tumor malignant phenotype as well as the involvement potential mechanism. We conducted our research via a combination of silico analysis and molecular biology techniques to investig …
However, few research have been carried out to explore the relationship between METTL7A and tumor malignant phenotype as well as the …
The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors.
Robey RW, Fitzsimmons CM, Guiblet WM, Frye WJE, González Dalmasy JM, Wang L, Russell DA, Huff LM, Perciaccante AJ, Ali-Rahmani F, Lipsey CC, Wade HM, Mitchell AV, Maligireddy SS, Terrero D, Butcher D, Edmondson EF, Jenkins LM, Nikitina T, Zhurkin VB, Tiwari AK, Piscopio AD, Totah RA, Bates SE, Arda HE, Gottesman MM, Batista PJ. Robey RW, et al. Mol Cancer Ther. 2024 Apr 2;23(4):464-477. doi: 10.1158/1535-7163.MCT-23-0144. Mol Cancer Ther. 2024. PMID: 38151817 Free PMC article.
We demonstrate that expression of METTL7A or METTL7B confers resistance to thiol-based HDACis and that both enzymes are capable of methylating thiol-containing HDACis. We thus propose that METTL7A and METTL7B confer resistance to thiol-based HDACis by methylating an …
We demonstrate that expression of METTL7A or METTL7B confers resistance to thiol-based HDACis and that both enzymes are capable of me …
31 results