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Year Number of Results
1997 2
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2001 9
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2004 6
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2006 8
2007 12
2008 6
2009 8
2010 9
2011 5
2012 8
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195 results

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Page 1
Emerging role of natural products in cancer immunotherapy.
Dong S, Guo X, Han F, He Z, Wang Y. Dong S, et al. Acta Pharm Sin B. 2022 Mar;12(3):1163-1185. doi: 10.1016/j.apsb.2021.08.020. Epub 2021 Aug 21. Acta Pharm Sin B. 2022. PMID: 35530162 Free PMC article. Review.
Epigenetic regulation in human melanoma: past and future.
Sarkar D, Leung EY, Baguley BC, Finlay GJ, Askarian-Amiri ME. Sarkar D, et al. Epigenetics. 2015;10(2):103-21. doi: 10.1080/15592294.2014.1003746. Epigenetics. 2015. PMID: 25587943 Free PMC article. Review.
Transcriptional and Immune Landscape of Cardiac Sarcoidosis.
Liu J, Ma P, Lai L, Villanueva A, Koenig A, Bean GR, Bowles DE, Glass C, Watson M, Lavine KJ, Lin CY. Liu J, et al. Circ Res. 2022 Sep 30;131(8):654-669. doi: 10.1161/CIRCRESAHA.121.320449. Epub 2022 Sep 16. Circ Res. 2022. PMID: 36111531 Free PMC article.
We also detected additional macrophage populations in cardiac sarcoidosis including HLA-DR (human leukocyte antigen-DR)(+) macrophages, SYTL3 (synaptotagmin-like protein 3)(+) macrophages and CD163(+) resident macrophages. ...SYTL3(+) macrophages …
We also detected additional macrophage populations in cardiac sarcoidosis including HLA-DR (human leukocyte antigen-DR)(+) macroph …
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E. Bennett JA, et al. Am J Surg Pathol. 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. Am J Surg Pathol. 2018. PMID: 30001237 Free PMC article.
All tumors were positive for HMB-45, cathepsin K, and at least one muscle marker, with most expressing melan-A (77%) and/or MiTF (79%). A PSF-TFE3 fusion was identified in one while another showed a RAD51B-OPHN1 fusion. ...
All tumors were positive for HMB-45, cathepsin K, and at least one muscle marker, with most expressing melan-A (77%) and/or MiTF (79% …
LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition.
Yadavalli N, Ferguson SM. Yadavalli N, et al. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2303789120. doi: 10.1073/pnas.2303789120. Epub 2023 Jul 24. Proc Natl Acad Sci U S A. 2023. PMID: 37487100 Free PMC article.
Here, we show that LRRK2, a protein that is tightly linked to Parkinson's disease, negatively regulates lysosome degradative activity in macrophages and microglia via a transcriptional mechanism. Depletion of LRRK2 and inhibition of LRRK2 kinase activity enhanced lysosomal …
Here, we show that LRRK2, a protein that is tightly linked to Parkinson's disease, negatively regulates lysosome degradative activity in …
Vitamin D(3) and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification.
Chan H, Li Q, Wang X, Liu WY, Hu W, Zeng J, Xie C, Kwong TNY, Ho IHT, Liu X, Chen H, Yu J, Ko H, Chan RCY, Ip M, Gin T, Cheng ASL, Zhang L, Chan MTV, Wong SH, Wu WKK. Chan H, et al. Autophagy. 2022 Sep;18(9):2050-2067. doi: 10.1080/15548627.2021.2016004. Epub 2022 Jan 6. Autophagy. 2022. PMID: 34989311 Free PMC article.
In mice, gavage with TcdB-hyperproducing C. difficile or injection of TcdB into ligated colon segments caused prominent MITF downregulation in macrophages. Vitamin D(3) and carbamazepine lessened TcdB-induced lysosomal dysfunction, inflammation and histological dama …
In mice, gavage with TcdB-hyperproducing C. difficile or injection of TcdB into ligated colon segments caused prominent MITF downregu …
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro.
Dolan MJ, Therrien M, Jereb S, Kamath T, Gazestani V, Atkeson T, Marsh SE, Goeva A, Lojek NM, Murphy S, White CM, Joung J, Liu B, Limone F, Eggan K, Hacohen N, Bernstein BE, Glass CK, Leinonen V, Blurton-Jones M, Zhang F, Epstein CB, Macosko EZ, Stevens B. Dolan MJ, et al. Nat Immunol. 2023 Aug;24(8):1382-1390. doi: 10.1038/s41590-023-01558-2. Epub 2023 Jul 27. Nat Immunol. 2023. PMID: 37500887 Free PMC article.
Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative diseases such as Alzheimer's disease. ...Using a new lentiviral approach, we demonstrated that the transcription factor MITF drives a disease-associated transcriptional signatur …
Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative diseases such as Alzheimer's disease. ...Usi …
Role and Regulation of Transcription Factors in Osteoclastogenesis.
Jiang T, Xia T, Qiao F, Wang N, Jiang Y, Xin H. Jiang T, et al. Int J Mol Sci. 2023 Nov 10;24(22):16175. doi: 10.3390/ijms242216175. Int J Mol Sci. 2023. PMID: 38003376 Free PMC article. Review.
Osteoclast differentiation is regulated by transcription factors NFATc1, MITF, C/EBPalpha, PU.1, NF-kappaB, and c-Fos. The transcriptional activity of osteoclasts is largely influenced by developmental and environmental signals with the involvement of co-factors, RNAs, epi …
Osteoclast differentiation is regulated by transcription factors NFATc1, MITF, C/EBPalpha, PU.1, NF-kappaB, and c-Fos. The transcript …
TGF-beta Negatively Regulates Mitf-E Expression and Canine Osteoclastogenesis.
Asai K, Hisasue M, Shimokawa F, Funaba M, Murakami M. Asai K, et al. Biochem Genet. 2018 Oct;56(5):542-552. doi: 10.1007/s10528-018-9860-y. Epub 2018 Apr 21. Biochem Genet. 2018. PMID: 29680988
We previously reported in a murine cell system that gene induction of the E isoform of microphthalmia-associated transcription factor (Mitf-E) was required and sufficient for osteoclastogenesis, while transforming growth factor-beta (TGF-beta) enhanced RANKL-induced Mit …
We previously reported in a murine cell system that gene induction of the E isoform of microphthalmia-associated transcription factor (Mi …
Mitf and Tfe3: members of a b-HLH-ZIP transcription factor family essential for osteoclast development and function.
Hershey CL, Fisher DE. Hershey CL, et al. Bone. 2004 Apr;34(4):689-96. doi: 10.1016/j.bone.2003.08.014. Bone. 2004. PMID: 15050900 Review.
Mutations in Mitf in multiple organisms result in osteopetrosis due to defective osteoclast development. ...Genetic evidence indicates that Mitf and Tfe3 carry out essential functions in osteoclast development. Mitf has been shown to reside downstream of the …
Mutations in Mitf in multiple organisms result in osteopetrosis due to defective osteoclast development. ...Genetic evidence indicate …
195 results