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189 results

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Page 1
Design and Simulation of the Microcantilever Biosensor for MITF Antigen and D5 Monoclonal Antibody Interaction Finite Element Analysis, and Experimental.
Akcali P, Kelleci K, Ozer S. Akcali P, et al. Curr Protein Pept Sci. 2024;25(3):256-266. doi: 10.2174/0113892037259122231013153546. Curr Protein Pept Sci. 2024. PMID: 37921167
In this study, the analytical and FEA of the microcantilever used in biomolecular analyses were compared with the experimental analysis results. METHODS: In this study, MITF antigen, which is a melanoma biomarker, and anti-MITF antibody (D5) were selected as …
In this study, the analytical and FEA of the microcantilever used in biomolecular analyses were compared with the experimental analysis resu …
Comprehensive multiplexed autoantibody profiling of patients with advanced urothelial cancer.
Ravi P, Freeman D, Thomas J, Ravi A, Mantia C, McGregor BA, Berchuck JE, Epstein I, Budde P, Ahangarian Abhari B, Rupieper E, Gajewski J, Schubert AS, Kilian AL, Bräutigam M, Zucht HD, Sonpavde G. Ravi P, et al. J Immunother Cancer. 2024 Feb 2;12(2):e008215. doi: 10.1136/jitc-2023-008215. J Immunother Cancer. 2024. PMID: 38309723 Free PMC article.
Bound AAbs were detected using an anti-immunoglobulin G-specific detection antibody conjugated to the fluorescent reporter dye phycoerythrin. The AAb reactivity was reported as the median fluorescence intensity for each color and sample using a Luminex FlexMAP3D analyzer. …
Bound AAbs were detected using an anti-immunoglobulin G-specific detection antibody conjugated to the fluorescent reporter dye phycoe …
[Immunohistochemistry of melanocytic tumours].
Mentzel T. Mentzel T. Pathologie (Heidelb). 2026 Mar 6. doi: 10.1007/s00292-026-01546-x. Online ahead of print. Pathologie (Heidelb). 2026. PMID: 41790207 Review. German.
Immunohistochemistry has an essential role in the diagnosis and differential diagnosis of benign and malignant melanocytic lesions, and underlying molecular changes are reflected by several newly characterized antibodies. Given the limited sensitivity and specificity of cl …
Immunohistochemistry has an essential role in the diagnosis and differential diagnosis of benign and malignant melanocytic lesions, and unde …
MITF Downregulation Induces Death in Human Mast Cell Leukemia Cells and Impairs IgE-Dependent Degranulation.
Proaño-Pérez E, Ollé L, Guo Y, Aparicio C, Guerrero M, Muñoz-Cano R, Martin M. Proaño-Pérez E, et al. Int J Mol Sci. 2023 Feb 9;24(4):3515. doi: 10.3390/ijms24043515. Int J Mol Sci. 2023. PMID: 36834926 Free PMC article.
MiRNA overexpression reduces MITF and MITF-dependent target expression in HMC-1. The same pattern was observed after MITF silencing. In addition, MITF inhibitor ML329 treatment reduces MITF expression and affects the viability and cell cycle pro …
MiRNA overexpression reduces MITF and MITF-dependent target expression in HMC-1. The same pattern was observed after MITF …
The Critical Role Played by Mitochondrial MITF Serine 73 Phosphorylation in Immunologically Activated Mast Cells.
Paruchuru LB, Govindaraj S, Razin E. Paruchuru LB, et al. Cells. 2022 Feb 8;11(3):589. doi: 10.3390/cells11030589. Cells. 2022. PMID: 35159398 Free PMC article.
In addition, a phosphorylation-mimicking mitochondrial MITF-S73D positively regulated the mitochondrial activity, thereby supporting mast cell degranulation. Thus, the present research findings highlight the prominence of mitochondrial MITF Serine 73 phosphorylation …
In addition, a phosphorylation-mimicking mitochondrial MITF-S73D positively regulated the mitochondrial activity, thereby supporting …
BPTF transduces MITF-driven prosurvival signals in melanoma cells.
Dar AA, Majid S, Bezrookove V, Phan B, Ursu S, Nosrati M, De Semir D, Sagebiel RW, Miller JR 3rd, Debs R, Cleaver JE, Kashani-Sabet M. Dar AA, et al. Proc Natl Acad Sci U S A. 2016 May 31;113(22):6254-8. doi: 10.1073/pnas.1606027113. Epub 2016 May 16. Proc Natl Acad Sci U S A. 2016. PMID: 27185926 Free PMC article.
Microphthalmia-associated transcription factor (MITF) plays a critical and complex role in melanocyte transformation. Although several downstream targets of MITF action have been identified, the precise mechanisms by which MITF promotes melanocytic tumor prog …
Microphthalmia-associated transcription factor (MITF) plays a critical and complex role in melanocyte transformation. Although severa …
Changes in AXL and/or MITF melanoma subpopulations in patients receiving immunotherapy.
Willemsen M, Bulgarelli J, Chauhan SK, Lereim RR, Angeli D, Grisendi G, Krebbers G, Davidson I, Kyte JA, Guidoboni M, Luiten RM, Bakker WJ. Willemsen M, et al. Immunooncol Technol. 2024 Nov 15;24:101009. doi: 10.1016/j.iotech.2024.101009. eCollection 2024 Dec. Immunooncol Technol. 2024. PMID: 39697983 Free PMC article.
We identify the presence of previously described AXL+ and MITF+ subpopulations in metastatic tissues both at the mRNA level and in situ at the protein level, and demonstrate that MITF+ melanoma cells are significantly decreased upon immunotherapy, while AXL+ melanom …
We identify the presence of previously described AXL+ and MITF+ subpopulations in metastatic tissues both at the mRNA level and in si …
Subcellular localization of Mitf in monocytic cells.
Lu SY, Wan HC, Li M, Lin YL. Lu SY, et al. Histochem Cell Biol. 2010 Jun;133(6):651-8. doi: 10.1007/s00418-010-0703-0. Epub 2010 May 1. Histochem Cell Biol. 2010. PMID: 20437053 Free PMC article.
We identified a domain encoded by Mitf exon 1B1b to be important for Mitf to commute between the cytoplasm and the nucleus. ...We showed that Mitf nuclear transport is greatly influenced by ratio of M-CSF/Mitf protein expression. ...
We identified a domain encoded by Mitf exon 1B1b to be important for Mitf to commute between the cytoplasm and the nucleus. .. …
Deciphering melanophagy: role of the PTK2-ITCH-MLANA-OPTN cascade on melanophagy in melanocytes.
Park NY, Jo DS, Park HJ, Bae JE, Kim YH, Kim JB, Lee HJ, Kim SH, Choi H, Lee HS, Yoshimori T, Lee DS, Lee JA, Kim P, Cho DH. Park NY, et al. Autophagy. 2025 Mar;21(3):664-673. doi: 10.1080/15548627.2024.2421695. Epub 2024 Nov 12. Autophagy. 2025. PMID: 39477686 Free PMC article.
This ubiquitinated MLANA is then recognized by an autophagy receptor protein, OPTN (optineurin). Additionally, a phospho-kinase antibody array revealed that TCTE activates PTK2 (protein tyrosine kinase 2), which phosphorylates ITCH, enhancing the ubiquitination of MLANA. . …
This ubiquitinated MLANA is then recognized by an autophagy receptor protein, OPTN (optineurin). Additionally, a phospho-kinase antibody …
Oncotargets in different renal cancer subtypes.
Moch H, Montironi R, Lopez-Beltran A, Cheng L, Mischo A. Moch H, et al. Curr Drug Targets. 2015;16(2):125-35. doi: 10.2174/1389450116666150126110632. Curr Drug Targets. 2015. PMID: 25619751 Review.
The new systemic therapies, including tyrosine kinase inhibitors, monoclonal antibodies, and mTOR inhibitors, aim to suppress angiogenesis with vascular endothelial growth factor as a target. ...Other gene alterations have been identified in hereditary cancer syndromes, e. …
The new systemic therapies, including tyrosine kinase inhibitors, monoclonal antibodies, and mTOR inhibitors, aim to suppress angioge …
189 results