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Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen E. Knapen MH, et al. Osteoporos Int. 2013 Sep;24(9):2499-507. doi: 10.1007/s00198-013-2325-6. Epub 2013 Mar 23. Osteoporos Int. 2013. PMID: 23525894 Clinical Trial.
We have investigated whether low-dose vitamin K2 supplements (menaquinone-7, MK-7) could beneficially affect bone health. Next to an improved vitamin K status, MK-7 supplementation significantly decreased the age-related decline in …
We have investigated whether low-dose vitamin K2 supplements (menaquinone-7, MK-7) could beneficially affect …
MK-7 and Its Effects on Bone Quality and Strength.
Sato T, Inaba N, Yamashita T. Sato T, et al. Nutrients. 2020 Mar 31;12(4):965. doi: 10.3390/nu12040965. Nutrients. 2020. PMID: 32244313 Free PMC article. Review.
MK-7 increases bone mineral density and promotes bone quality and strength. Collagen production, and thus, bone quality may be affected by MK-7 or MK-4 converted from MK-7. In this review, we comprehensively discuss t …
MK-7 increases bone mineral density and promotes bone quality and strength. Collagen production, and thus, bo …
Effects of Menaquinone-7 on the Bone Health of Growing Rats under Calcium Restriction: New Insights from Microbiome-Metabolomics.
Yuan Y, Szeto IM, Li N, Yang H, Zhou Y, Liu B, He F, Zhang L, Duan S, Chen J. Yuan Y, et al. Nutrients. 2023 Jul 31;15(15):3398. doi: 10.3390/nu15153398. Nutrients. 2023. PMID: 37571336 Free PMC article.
The aim of this study was to investigate the effects of dietary menaquinone-7 (MK-7) on bone accrual in growing Sprague-Dawley rats under calcium restriction. ...The gut-bone axis holds promise as an efficacious target for ameliorating ca …
The aim of this study was to investigate the effects of dietary menaquinone-7 (MK-7) on bone accrual in g …
Limosilactobacillus reuteri with menaquinone-7 improves bone biomechanics and microarchitecture in ovariectomized mice: preliminary study.
Santos TA, Ribeiro JL, Battistelli LS, Anbinder AL. Santos TA, et al. J Bone Miner Metab. 2025 Jul;43(4):335-347. doi: 10.1007/s00774-025-01600-3. Epub 2025 Apr 18. J Bone Miner Metab. 2025. PMID: 40249504
AIM: This study aimed to evaluate the effects of Limosilactobacillus reuteri (LR) and its combination with menaquinone-7 (MK-7; K) on ovariectomy-induced bone loss in mice and on bacterial growth in vitro. ...CONCLUSION: L. reuteri and its combi …
AIM: This study aimed to evaluate the effects of Limosilactobacillus reuteri (LR) and its combination with menaquinone-7 (M …
Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial.
Naiyarakseree N, Phannajit J, Naiyarakseree W, Mahatanan N, Asavapujanamanee P, Lekhyananda S, Vanichakarn S, Avihingsanon Y, Praditpornsilpa K, Eiam-Ong S, Susantitaphong P. Naiyarakseree N, et al. Nutrients. 2023 May 23;15(11):2422. doi: 10.3390/nu15112422. Nutrients. 2023. PMID: 37299386 Free PMC article. Clinical Trial.
The present study was conducted to evaluate the efficacy of menaquinone-7 (MK-7) supplementation on arterial stiffness in chronic HD patients. METHODS: This open-label multicenter randomized clinical trial was conducted in 96 HD patients who had arteri …
The present study was conducted to evaluate the efficacy of menaquinone-7 (MK-7) supplementation on arterial sti …
Determination of Vitamin K1, MK-4, MK-7, and D Levels in Human Serum of Postmenopausal Osteoporosis Women Based on High Stability LC-MS/MS: MK-7 May Be a New Marker of Bone Metabolism.
Li C, Liang C, Kong Z, Su Y, Ren W, Dong H, Wu Y, Yang N, Liu R, Wu J, Zheng Y. Li C, et al. Ann Nutr Metab. 2023;79(3):334-342. doi: 10.1159/000531065. Epub 2023 May 30. Ann Nutr Metab. 2023. PMID: 37253343 Free article.
INTRODUCTION: Vitamin K (VK) as well as vitamin D (VD) plays an important role in osteoporosis. Vitamin K1 (VK1), vitamin K2 (VK2, menaquinone-4 (MK-4), and menaquinone-7 (MK-7)) are significant for the metabolism of skeletal muscle. 25-hydroxyv …
INTRODUCTION: Vitamin K (VK) as well as vitamin D (VD) plays an important role in osteoporosis. Vitamin K1 (VK1), vitamin K2 (VK2, menaqu …
Microstructural and mechanical recovery of bone in ovariectomized rats: The effects of menaquinone-7.
Iwamoto D, Masaki C, Shibata Y, Watanabe C, Nodai T, Munemasa T, Mukaibo T, Kondo Y, Hosokawa R. Iwamoto D, et al. J Mech Behav Biomed Mater. 2021 Aug;120:104571. doi: 10.1016/j.jmbbm.2021.104571. Epub 2021 May 21. J Mech Behav Biomed Mater. 2021. PMID: 34029943
Micro-computed tomography revealed irregular trabecular architecture, hollow marrow cavities, and sparse trabecular bone in the femurs of the OVX group. Trabecular bone structure analysis showed that the MK-7 group had greater bone volume per ti …
Micro-computed tomography revealed irregular trabecular architecture, hollow marrow cavities, and sparse trabecular bone in the femur …
Effects of Menaquinone-7 on Bone Turnover Markers, Femoral Mechanical Resistance, and Histology in Young Ovariectomized Rats.
Jecan A, Tomoaia G, Gherman LM, Rus V, Pop RM, Popa C, Melinte RM, Jecan-Toader D, Apostu D, Simionescu L, Blănaru V, Oltean-Dan D. Jecan A, et al. Nutrients. 2026 May 9;18(10):1510. doi: 10.3390/nu18101510. Nutrients. 2026. PMID: 42196970 Free PMC article.
Established pharmacological therapies remain the cornerstone of osteoporosis management, while nutritional factors continue to be investigated for their potential supportive role in bone metabolism. Menaquinone-7 (MK-7), a form of vitamin K2, ha …
Established pharmacological therapies remain the cornerstone of osteoporosis management, while nutritional factors continue to be investigat …
Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postmenopausal women.
Rønn SH, Harsløf T, Pedersen SB, Langdahl BL. Rønn SH, et al. Eur J Endocrinol. 2016 Dec;175(6):541-549. doi: 10.1530/EJE-16-0498. Epub 2016 Sep 13. Eur J Endocrinol. 2016. PMID: 27625301 Clinical Trial.
We investigated the effect of vitamin MK-7 on undercarboxylated osteocalcin (ucOC), and bone mass and quality. DESIGN: We conducted a randomised, placebo-controlled, double-blinded clinical trial. ...This suggests that vitamin MK-7 preserves tra …
We investigated the effect of vitamin MK-7 on undercarboxylated osteocalcin (ucOC), and bone mass and quality. DESIGN: …
Stimulatory effect of menaquinone-7 (vitamin K2) on osteoblastic bone formation in vitro.
Yamaguchi M, Sugimoto E, Hachiya S. Yamaguchi M, et al. Mol Cell Biochem. 2001 Jul;223(1-2):131-7. doi: 10.1023/a:1017930931736. Mol Cell Biochem. 2001. PMID: 11681714
The effect of menaquinone-7 (MK-7) on osteoblastic bone formation was investigated. Femoral-diaphyseal and metaphyseal tissues of young male rats (4 weeks old) were cultured for 48 h in a medium containing either vehicle or MK-7 (1 …
The effect of menaquinone-7 (MK-7) on osteoblastic bone formation was investigated. Femoral-diaphyseal an …
85 results