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A genome-first approach to variants in MLXIPL and their association with hepatic steatosis and plasma lipids.
Hehl L, Creasy KT, Vitali C, Scorletti E, Seeling KS, Vell MS, Rendel MD, Conlon D, Vujkovic M, Zandvakili I, Trautwein C, Schneider KM, Rader DJ, Schneider CV; Regeneron Genetics Center. Hehl L, et al. Hepatol Commun. 2024 Apr 26;8(5):e0427. doi: 10.1097/HC9.0000000000000427. eCollection 2024 May 1. Hepatol Commun. 2024. PMID: 38668731 Free PMC article.
However, the role of these variants in steatotic liver disease (SLD) is unclear. METHODS: We used a genome-first approach to analyze a variety of metabolic phenotypes and clinical outcomes associated with a common missense variant in MLXIPL, Gln241His, in 2 large bi …
However, the role of these variants in steatotic liver disease (SLD) is unclear. METHODS: We used a genome-first approach to analyze …
ChREBP mediates metabolic remodeling in FBP1-deficient liver.
Wang CM, Bai QF, Liu YJ, Lin J, Wei CC, Ma XH, Zhao JM, Zhu M, Chen YX, Shi YN, Shi JH, Zhang WJ. Wang CM, et al. Am J Physiol Cell Physiol. 2025 Apr 1;328(4):C1234-C1246. doi: 10.1152/ajpcell.00875.2024. Epub 2025 Mar 7. Am J Physiol Cell Physiol. 2025. PMID: 40055186 Free article.
Here we demonstrate that carbohydrate response element-binding protein (ChREBP) mediates lipid metabolic remodeling and promotes progressive triglyceride accumulation against metabolic injury in adult FBP1-deficient liver. Inducible liver-specific deletion of …
Here we demonstrate that carbohydrate response element-binding protein (ChREBP) mediates lipid metabolic remodeling and promotes progressive …
Isoflavones as a smart curer for non-alcoholic fatty liver disease and pathological adiposity via ChREBP and Wnt signaling.
Kim MH, Kang KS. Kim MH, et al. Prev Med. 2012 May;54 Suppl:S57-63. doi: 10.1016/j.ypmed.2011.12.018. Epub 2011 Dec 28. Prev Med. 2012. PMID: 22227283 Review.
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) and pathological adiposity has emerged as an important modern disease. ...
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) and pathological adiposity has emerged as an important modern disease. ...
Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance.
Lei Y, Hu Q, Gu J. Lei Y, et al. Pathol Oncol Res. 2020 Apr;26(2):1331-1340. doi: 10.1007/s12253-019-00708-y. Epub 2019 Aug 12. Pathol Oncol Res. 2020. PMID: 31407220 Free PMC article.
ChREBP, GLUT2 and GLUT1 immunohistochemistry were performed on liver tissue array containing normal liver tissue, HCC adjacent tissue and cancer tissue of different HCC stages. ...We found that ChREBP protein expression tended to be positively correlated to liver …
ChREBP, GLUT2 and GLUT1 immunohistochemistry were performed on liver tissue array containing normal liver tissue, HCC adjacent …
Is C771G polymorphism of MLX interacting protein-like (MLXIPL) gene a novel genetic risk factor for non-alcoholic fatty liver disease?
Seifi M, Ghasemi A, Namipashaki A, Samadikuchaksaraei A. Seifi M, et al. Cell Mol Biol (Noisy-le-grand). 2014;60(3):37-42. Cell Mol Biol (Noisy-le-grand). 2014. PMID: 26177557
In a recent study, a genome-wide scan has identified C771G (His241Gln) polymorphism of MLX interacting protein like (MLXIPL) gene that is associated with the level of plasma triglycerides. Since, no study has been reported on the association between MLXIPL gene and …
In a recent study, a genome-wide scan has identified C771G (His241Gln) polymorphism of MLX interacting protein like (MLXIPL) gene tha …
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
Coffee and Caffeine Genetics Consortium; Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N, Fischer K, Renstrom F, Ngwa JS, Huikari V, Cavadino A, Nolte IM, Teumer A, Yu K, Marques-Vidal P, Rawal R, Manichaikul A, Wojczynski MK, Vink JM, Zhao JH, Burlutsky G, Lahti J, Mikkilä V, Lemaitre RN, Eriksson J, Musani SK, Tanaka T, Geller F, Luan J, Hui J, Mägi R, Dimitriou M, Garcia ME, Ho WK, Wright MJ, Rose LM, Magnusson PK, Pedersen NL, Couper D, Oostra BA, Hofman A, Ikram MA, Tiemeier HW, Uitterlinden AG, van Rooij FJ, Barroso I, Johansson I, Xue L, Kaakinen M, Milani L, Power C, Snieder H, Stolk RP, Baumeister SE, Biffar R, Gu F, Bastardot F, Kutalik Z, Jacobs DR Jr, Forouhi NG, Mihailov E, Lind L, Lindgren C, Michaëlsson K, Morris A, Jensen M, Khaw KT, Luben RN, Wang JJ, Männistö S, Perälä MM, Kähönen M, Lehtimäki T, Viikari J, Mozaffarian D, Mukamal K, Psaty BM, Döring A, Heath AC, Montgomery GW, Dahmen N, Carithers T, Tucker KL, Ferrucci L, Boyd HA, Melbye M, Treur JL, Mellström D, Hottenga JJ, Prokopenko I, Tönjes A, Deloukas P, Kanoni S, Lorentzon M, Houston DK, Liu Y, Danesh J, Rasheed A, Mason MA, Zonderman AB, Franke L, Kristal BS; International P… See abstract for full author list ➔ Coffee and Caffeine Genetics Consortium, et al. Mol Psychiatry. 2015 May;20(5):647-656. doi: 10.1038/mp.2014.107. Epub 2014 Oct 7. Mol Psychiatry. 2015. PMID: 25288136 Free PMC article. Review.
Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine. Two map to GCKR and MLXIPL genes related to metabolic traits but lacking known roles in coffee consumption. Enhancer a …
Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4 …
ChREBP expression in the liver, adipose tissue and differentiated preadipocytes in human obesity.
Hurtado del Pozo C, Vesperinas-García G, Rubio MÁ, Corripio-Sánchez R, Torres-García AJ, Obregon MJ, Calvo RM. Hurtado del Pozo C, et al. Biochim Biophys Acta. 2011 Dec;1811(12):1194-200. doi: 10.1016/j.bbalip.2011.07.016. Epub 2011 Jul 30. Biochim Biophys Acta. 2011. PMID: 21840420 Free article.
Liver and OM and SC adipose tissue biopsies were obtained from lean and obese patients. ...We found opposing results in terms of ChREBP regulation in the liver and adipose samples. ChREBP increased in the liver from obese compared to lean subjects, whereas th …
Liver and OM and SC adipose tissue biopsies were obtained from lean and obese patients. ...We found opposing results in terms of ChRE …
De novo lipogenesis in human fat and liver is linked to ChREBP-beta and metabolic health.
Eissing L, Scherer T, Tödter K, Knippschild U, Greve JW, Buurman WA, Pinnschmidt HO, Rensen SS, Wolf AM, Bartelt A, Heeren J, Buettner C, Scheja L. Eissing L, et al. Nat Commun. 2013;4:1528. doi: 10.1038/ncomms2537. Nat Commun. 2013. PMID: 23443556 Free PMC article.
By contrast, lipogenic enzymes are substantially upregulated in the liver of obese subjects. Bariatric weight loss restored de novo lipogenesis and glucose transporter-4 gene expression in white adipose tissue. Notably, lipogenic gene expression in both white adipose tissu …
By contrast, lipogenic enzymes are substantially upregulated in the liver of obese subjects. Bariatric weight loss restored de novo l …
High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia.
Nakayama K, Yanagisawa Y, Ogawa A, Ishizuka Y, Munkhtulga L, Charupoonphol P, Supannnatas S, Kuartei S, Chimedregzen U, Koda Y, Ishida T, Kagawa Y, Iwamoto S. Nakayama K, et al. J Hum Genet. 2011 Dec;56(12):828-33. doi: 10.1038/jhg.2011.109. Epub 2011 Sep 22. J Hum Genet. 2011. PMID: 21938000
MLXIPL is a transcription factor integral to the regulation of glycolysis and lipogenesis in the liver. Common variants of the MLXIPL gene (MLXIPL) are known to influence plasma triglyceride levels in people of European descent. ...
MLXIPL is a transcription factor integral to the regulation of glycolysis and lipogenesis in the liver. Common variants of the …
Role of ChREBP-PPARα-FGF21 Axis in Metabolic Dysfunction of MASLD.
Palacios Girón KM, Hernandez Nazara ZH, Maldonado-González M, Martínez-López E, Sánchez Muñoz MP, Bautista López CA, Aguiñaga MSA, Dominguez-Rosales JA, Vargas-Guerrero B, Ruíz-Madrigal B. Palacios Girón KM, et al. Int J Mol Sci. 2025 Nov 26;26(23):11425. doi: 10.3390/ijms262311425. Int J Mol Sci. 2025. PMID: 41373582 Free PMC article.
Key genes linked to liver dysfunction, such as MLXIPL, PPARA, and FGF21, are under-researched in humans. We aimed to evaluate the ChREBP-PPARalpha-FGF21 axis in relation to metabolic liver dysfunction in MHO and MUL individuals. ...The MHL, MUL, MHO, and MUO …
Key genes linked to liver dysfunction, such as MLXIPL, PPARA, and FGF21, are under-researched in humans. We aimed to evaluate …
24 results