Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 1
1997 4
1998 8
1999 10
2000 20
2001 29
2002 17
2003 25
2004 44
2005 44
2006 47
2007 53
2008 84
2009 67
2010 74
2011 84
2012 84
2013 82
2014 97
2015 111
2016 104
2017 114
2018 88
2019 100
2020 124
2021 126
2022 107
2023 113
2024 91
2025 2

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

1,751 results

Results by year

Filters applied: . Clear all
Page 1
Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression.
Niland S, Riscanevo AX, Eble JA. Niland S, et al. Int J Mol Sci. 2021 Dec 23;23(1):146. doi: 10.3390/ijms23010146. Int J Mol Sci. 2021. PMID: 35008569 Free PMC article. Review.
As a deeper understanding of the underlying functional mechanisms is beneficial for the development of new prognostic and predictive markers and for targeted therapies, this review examined the current knowledge of the interplay of the various MMPs in the cancer context on the pr …
As a deeper understanding of the underlying functional mechanisms is beneficial for the development of new prognostic and predictive markers …
The interplay of Cxcl10(+)/Mmp14(+) monocytes and Ccl3(+) neutrophils proactively mediates silica-induced pulmonary fibrosis.
Cheng D, Lian W, Wang T, Xi S, Jia X, Li Z, Xiong H, Wang Y, Sun W, Zhou S, Peng L, Han L, Liu Y, Ni C. Cheng D, et al. J Hazard Mater. 2024 Apr 5;467:133713. doi: 10.1016/j.jhazmat.2024.133713. Epub 2024 Feb 4. J Hazard Mater. 2024. PMID: 38335607
Herein, single-cell RNA sequencing of the lung tissue of silicosis mice identified two monocyte subsets, which were characterized by Cxcl10 and Mmp14 and enriched in fibrotic mouse lungs. Both Cxcl10(+) and Mmp14(+) monocyte subsets exhibited activation of inflammat …
Herein, single-cell RNA sequencing of the lung tissue of silicosis mice identified two monocyte subsets, which were characterized by Cxcl10 …
TGFbeta attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.
Wang G, Chen S, Xie Z, Shen S, Xu W, Chen W, Li X, Wu Y, Li L, Liu B, Ding X, Qin A, Fan S. Wang G, et al. Ann Rheum Dis. 2020 Aug;79(8):1111-1120. doi: 10.1136/annrheumdis-2019-216911. Epub 2020 May 14. Ann Rheum Dis. 2020. PMID: 32409323 Free PMC article.
The molecular mechanism study revealed that FBXO6 decreased MMP14 by ubiquitination and degradation, leading to inhibited proteolytic activation of MMP13. ...CONCLUSIONS: TGFbeta-SMAD2/3 signalling pathway suppressed MMP13 activation by upregulating of FBXO6 transcription …
The molecular mechanism study revealed that FBXO6 decreased MMP14 by ubiquitination and degradation, leading to inhibited proteolytic …
MMP14(high) macrophages orchestrate progressive pulmonary fibrosis in SR-Ag-induced hypersensitivity pneumonitis.
Peng D, Li J, Li Y, Bai L, Xiong A, He X, Li X, Ran Q, Zhang L, Jiang M, Wang J, Leung EL, Yang P, Li G. Peng D, et al. Pharmacol Res. 2024 Feb;200:107070. doi: 10.1016/j.phrs.2024.107070. Epub 2024 Jan 11. Pharmacol Res. 2024. PMID: 38218353 Free article.
We demonstrated that suppressing toll-like receptor 2 (TLR2) and nuclear factor kappa-B (NF-kappaB) could attenuate MMP14 expression and exosome secretion in macrophages stimulation with SR-Ag. The exosomes derived from MMP14-overexpressing macrophages were found to …
We demonstrated that suppressing toll-like receptor 2 (TLR2) and nuclear factor kappa-B (NF-kappaB) could attenuate MMP14 expression …
MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues.
Gonzalez-Molina J, Gramolelli S, Liao Z, Carlson JW, Ojala PM, Lehti K. Gonzalez-Molina J, et al. Cells. 2019 Aug 28;8(9):991. doi: 10.3390/cells8090991. Cells. 2019. PMID: 31466240 Free PMC article. Review.
MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell-cell and cell-extracellular matrix (ECM) communication. ...Here, we provide an overview of the function and regulation of MMP14 and we discuss their relationship wi …
MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell-cell and cell-extracellular mat …
Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts.
Yeung CC, Garva R, Pickard A, Lu Y, Mallikarjun V, Swift J, Taylor SH, Rai J, Eyre DR, Chaturvedi M, Itoh Y, Meng QJ, Mauch C, Zigrino P, Kadler KE. Yeung CC, et al. Matrix Biol. 2023 Dec;124:8-22. doi: 10.1016/j.matbio.2023.10.002. Epub 2023 Oct 31. Matrix Biol. 2023. PMID: 37913834 Free article.
Here, we first showed that the collagenase, membrane type I-matrix metalloproteinase (MT1-MMP, encoded by Mmp14), is regulated by the circadian clock in postnatal mouse tendon. Next, we generated tamoxifen-induced Col1a2-Cre-ERT2::Mmp14 KO mice (Mmp14 conditi …
Here, we first showed that the collagenase, membrane type I-matrix metalloproteinase (MT1-MMP, encoded by Mmp14), is regulated by the …
HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer.
Hu XT, Xing W, Zhao RS, Tan Y, Wu XF, Ao LQ, Li Z, Yao MW, Yuan M, Guo W, Li SZ, Yu J, Ao X, Xu X. Hu XT, et al. J Exp Clin Cancer Res. 2020 Dec 2;39(1):270. doi: 10.1186/s13046-020-01783-9. J Exp Clin Cancer Res. 2020. PMID: 33267897 Free PMC article.
LncRNA H19 functioned as a miR-22-3P sponge to increase the expression of MMP14. HDAC2 loss strongly promoted CRC lung metastasis, which was suppressed LncRNA H19 knockdown. CONCLUSION: Our study supports HDAC2 as a CRC metastasis suppressor through the inhibition of EMT a …
LncRNA H19 functioned as a miR-22-3P sponge to increase the expression of MMP14. HDAC2 loss strongly promoted CRC lung metastasis, wh …
Apoptosis-associated genetic mechanisms in the transition from rheumatoid arthritis to osteoporosis: A bioinformatics and functional analysis approach.
Lo HJ, Tsai CH, Huang TW. Lo HJ, et al. APL Bioeng. 2024 Nov 5;8(4):046107. doi: 10.1063/5.0233961. eCollection 2024 Dec. APL Bioeng. 2024. PMID: 39507523 Free PMC article.
The study highlighted two crucial genes: ATXN2L and MMP14. These genes were identified through various analyses and found to be significantly associated with the progression of RA and OP. Gene Set Enrichment Analysis of ATXN2L and MMP14 revealed their involvement in …
The study highlighted two crucial genes: ATXN2L and MMP14. These genes were identified through various analyses and found to be signi …
Locally produced autoantibodies in cancer.
Centuori SM, Bhattacharya D. Centuori SM, et al. Cell. 2022 Mar 31;185(7):1110-1111. doi: 10.1016/j.cell.2022.03.006. Cell. 2022. PMID: 35364029 Free article.
In a new study by Mazor et al., matrix metalloproteinase 14 (MMP14), a self-antigen that is overexpressed by ovarian cancers, is shown to drive B cell activation and autoantibody production in tertiary lymphoid structures (Mazor et al., 2022)....
In a new study by Mazor et al., matrix metalloproteinase 14 (MMP14), a self-antigen that is overexpressed by ovarian cancers, is show …
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis.
Xia XD, Gill G, Lin H, Roth DM, Gu HM, Wang XJ, Su FY, Alabi A, Alexiou M, Zhang Z, Wang GQ, Graf D, Zhang DW. Xia XD, et al. Matrix Biol. 2023 Sep;122:10-17. doi: 10.1016/j.matbio.2023.08.003. Epub 2023 Aug 19. Matrix Biol. 2023. PMID: 37598898 Free article.
However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP inhibition as a safe treatment in adults, we generated global Mmp14 tamoxifen-induced conditional knockout (Mmp14(kd)) mice a …
However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP …
1,751 results