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Compound prioritization methods increase rates of chemical probe discovery in model organisms.
Wallace IM, Urbanus ML, Luciani GM, Burns AR, Han MK, Wang H, Arora K, Heisler LE, Proctor M, St Onge RP, Roemer T, Roy PJ, Cummins CL, Bader GD, Nislow C, Giaever G. Wallace IM, et al. Chem Biol. 2011 Oct 28;18(10):1273-83. doi: 10.1016/j.chembiol.2011.07.018. Chem Biol. 2011. PMID: 22035796 Free PMC article.
Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.
Luciani GM, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ. Luciani GM, et al. Nat Chem Biol. 2011 Nov 6;7(12):891-3. doi: 10.1038/nchembio.698. Nat Chem Biol. 2011. PMID: 22057127
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