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2011 3
2012 2
2020 0
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Page 1
Compound prioritization methods increase rates of chemical probe discovery in model organisms.
Wallace IM, Urbanus ML, Luciani GM, Burns AR, Han MK, Wang H, Arora K, Heisler LE, Proctor M, St Onge RP, Roemer T, Roy PJ, Cummins CL, Bader GD, Nislow C, Giaever G. Wallace IM, et al. Chem Biol. 2011 Oct 28;18(10):1273-83. doi: 10.1016/j.chembiol.2011.07.018. Chem Biol. 2011. PMID: 22035796 Free PMC article.
Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice.
Hager L, Li L, Pun H, Liu L, Hossain MA, Maguire GF, Naples M, Baker C, Magomedova L, Tam J, Adeli K, Cummins CL, Connelly PW, Ng DS. Hager L, et al. J Biol Chem. 2012 Jun 8;287(24):20755-68. doi: 10.1074/jbc.M112.340919. Epub 2012 Apr 12. J Biol Chem. 2012. PMID: 22500017 Free PMC article.
A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.
Wollam J, Magner DB, Magomedova L, Rass E, Shen Y, Rottiers V, Habermann B, Cummins CL, Antebi A. Wollam J, et al. PLoS Biol. 2012;10(4):e1001305. doi: 10.1371/journal.pbio.1001305. Epub 2012 Apr 10. PLoS Biol. 2012. PMID: 22505847 Free PMC article.
Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.
Luciani GM, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ. Luciani GM, et al. Nat Chem Biol. 2011 Nov 6;7(12):891-3. doi: 10.1038/nchembio.698. Nat Chem Biol. 2011. PMID: 22057127
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.
Wollam J, Magomedova L, Magner DB, Shen Y, Rottiers V, Motola DL, Mangelsdorf DJ, Cummins CL, Antebi A. Wollam J, et al. Aging Cell. 2011 Oct;10(5):879-84. doi: 10.1111/j.1474-9726.2011.00733.x. Epub 2011 Aug 7. Aging Cell. 2011. PMID: 21749634 Free PMC article.
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