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242 results

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MOTS-c Functionally Prevents Metabolic Disorders.
Gao Y, Wei X, Wei P, Lu H, Zhong L, Tan J, Liu H, Liu Z. Gao Y, et al. Metabolites. 2023 Jan 13;13(1):125. doi: 10.3390/metabo13010125. Metabolites. 2023. PMID: 36677050 Free PMC article. Review.
As a new member of the mitochondrial-derived peptide family, mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is regarding a peptide hormone that could reduce insulin resistance, prevent obesity, improve muscle function, promote bone metabolism, en …
As a new member of the mitochondrial-derived peptide family, mitochondrial open reading frame of the 12S rRNA-c (MOTS-c …
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.
Zheng Y, Wei Z, Wang T. Zheng Y, et al. Front Endocrinol (Lausanne). 2023 Jan 25;14:1120533. doi: 10.3389/fendo.2023.1120533. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36761202 Free PMC article. Review.
Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c) is a mitochondrial-derived peptide composed of 16 amino acids encoded by the 12S rRNA region of the mitochondrial genome. ...Nevertheless, MOTS-c has been used less frequently in disease treatmen …
Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c) is a mitochondrial-derived peptide composed of 16 amino acids encoded …
MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.
Benayoun BA, Lee C. Benayoun BA, et al. Bioessays. 2019 Sep;41(9):e1900046. doi: 10.1002/bies.201900046. Epub 2019 Aug 5. Bioessays. 2019. PMID: 31378979 Free PMC article. Review.
On the contrary, no mitochondrial-encoded factors are known to actively regulate nuclear gene expression. MOTS-c (mitochondrial open reading frame of the 12S ribosomal RNA type-c) is a recently identified peptide encoded within the mitochondrial 12S ribosomal RNA ge …
On the contrary, no mitochondrial-encoded factors are known to actively regulate nuclear gene expression. MOTS-c (mitochondria …
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. Lee C, et al. Cell Metab. 2015 Mar 3;21(3):443-54. doi: 10.1016/j.cmet.2015.02.009. Cell Metab. 2015. PMID: 25738459 Free PMC article.
Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) that regulates insulin sensitivity and metabolic homeostasis. Its primary target organ appears to be the skelet …
Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open read …
Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.
Yin Y, Li Y, Ma B, Ren C, Zhao S, Li J, Gong Y, Yang H, Li J. Yin Y, et al. Adv Sci (Weinh). 2024 Nov;11(43):e2405620. doi: 10.1002/advs.202405620. Epub 2024 Sep 25. Adv Sci (Weinh). 2024. PMID: 39321430 Free PMC article.
Although recent clinical studies have suggested a possible link between MOTS-c and human cancer, the role of MOTS-c in tumorigenesis has yet to be investigated. ...In conclusion, this study reveals a crucial role of MOTS-c in OC and provi …
Although recent clinical studies have suggested a possible link between MOTS-c and human cancer, the role of MOTS-c …
MOTS-c: A potential anti-pulmonary fibrosis factor derived by mitochondria.
Zhang Z, Chen D, Du K, Huang Y, Li X, Li Q, Lv X. Zhang Z, et al. Mitochondrion. 2023 Jul;71:76-82. doi: 10.1016/j.mito.2023.06.002. Epub 2023 Jun 10. Mitochondrion. 2023. PMID: 37307934 Review.
However, Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), a peptide encoded by the mitochondrial genome, has shown promising effects on glucose and lipid metabolism, cellular and mitochondrial homeostasis, as well as the reduction of systemic infl …
However, Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), a peptide encoded by the mitochondrial genome, ha …
The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.
Yin Y, Pan Y, He J, Zhong H, Wu Y, Ji C, Liu L, Cui X. Yin Y, et al. Pharmacol Res. 2022 Jan;175:105987. doi: 10.1016/j.phrs.2021.105987. Epub 2021 Nov 17. Pharmacol Res. 2022. PMID: 34798268 Free article.
Here, we demonstrate that MOTS-c can be an effective treatment for GDM. A GDM mouse model was established by short term high-fat diet combined with low-dose streptozotocin (STZ) treatment while MOTS-c was administrated daily during pregnancy. ...In add …
Here, we demonstrate that MOTS-c can be an effective treatment for GDM. A GDM mouse model was established by short term high-f …
Role of MOTS-c in the regulation of bone metabolism.
Yi X, Hu G, Yang Y, Li J, Jin J, Chang B. Yi X, et al. Front Physiol. 2023 May 2;14:1149120. doi: 10.3389/fphys.2023.1149120. eCollection 2023. Front Physiol. 2023. PMID: 37200834 Free PMC article. Review.
MOTS-c, a mitochondrial-derived peptide (MDP), is an essential regulatory mediator of cell protection and energy metabolism and is involved in the development of specific diseases. ...Exercise effectively upregulates the expression of MOTS-c, but the s …
MOTS-c, a mitochondrial-derived peptide (MDP), is an essential regulatory mediator of cell protection and energy metabolism an …
MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases.
Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC. Mohtashami Z, et al. Int J Mol Sci. 2022 Oct 9;23(19):11991. doi: 10.3390/ijms231911991. Int J Mol Sci. 2022. PMID: 36233287 Free PMC article. Review.
MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA region of the mitochondrial genome. ...Aging is characterized by gradual loss of (mitochondrial) metabolic balance, decreased muscle homeostasis and eventual diminished physical capa …
MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA region of the mitochondrial genome. ...Agi …
MOTS-c modulates skeletal muscle function by directly binding and activating CK2.
Kumagai H, Kim SJ, Miller B, Zempo H, Tanisawa K, Natsume T, Lee SH, Wan J, Leelaprachakul N, Kumagai ME, Ramirez R 2nd, Mehta HH, Cao K, Oh TJ, Wohlschlegel JA, Sha J, Nishida Y, Fuku N, Dobashi S, Miyamoto-Mikami E, Takaragawa M, Fuku M, Yoshihara T, Naito H, Kawakami R, Torii S, Midorikawa T, Oka K, Hara M, Iwasaka C, Yamada Y, Higaki Y, Tanaka K, Yen K, Cohen P. Kumagai H, et al. iScience. 2024 Oct 19;27(11):111212. doi: 10.1016/j.isci.2024.111212. eCollection 2024 Nov 15. iScience. 2024. PMID: 39559755 Free PMC article.
MOTS-c is a mitochondrial microprotein that improves metabolism. Here, we demonstrate CK2 is a direct and functional target of MOTS-c. ...Notably, a naturally occurring MOTS-c variant, K14Q MOTS-c, has reduced binding to CK2 …
MOTS-c is a mitochondrial microprotein that improves metabolism. Here, we demonstrate CK2 is a direct and functional target of …
242 results