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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. Lee C, et al. Cell Metab. 2015 Mar 3;21(3):443-54. doi: 10.1016/j.cmet.2015.02.009. Cell Metab. 2015. PMID: 25738459 Free PMC article.
Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) that regulates insulin sensitivity and metabolic homeostasis. Its primary target organ app …
Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open read …
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.
Zheng Y, Wei Z, Wang T. Zheng Y, et al. Front Endocrinol (Lausanne). 2023 Jan 25;14:1120533. doi: 10.3389/fendo.2023.1120533. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36761202 Free PMC article. Review.
The MOTS-c protein is transferred to the nucleus during metabolic stress and directs the expression of nuclear genes to promote cell balance. ...Throughout this paper, we discussed the discovery and physiological function of mitochondrial-derived polypeptide …
The MOTS-c protein is transferred to the nucleus during metabolic stress and directs the expression of nuclear genes to …
The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.
Yin Y, Pan Y, He J, Zhong H, Wu Y, Ji C, Liu L, Cui X. Yin Y, et al. Pharmacol Res. 2022 Jan;175:105987. doi: 10.1016/j.phrs.2021.105987. Epub 2021 Nov 17. Pharmacol Res. 2022. PMID: 34798268 Free article.
MOTS-c significantly alleviated hyperglycemia, improved insulin sensitivity and glucose tolerance, and reduced birth weight and the death of offspring induced by GDM. Similar to a previous study, MOTS-c also could activate insulin …
MOTS-c significantly alleviated hyperglycemia, improved insulin sensitivity and glucose tolerance, and reduced b …
Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging.
Wan W, Zhang L, Lin Y, Rao X, Wang X, Hua F, Ying J. Wan W, et al. J Transl Med. 2023 Jan 20;21(1):36. doi: 10.1186/s12967-023-03885-2. J Transl Med. 2023. PMID: 36670507 Free PMC article. Review.
MOTS-c is a peptide encoded by the short open reading frame of the mitochondrial 12S rRNA gene. It is significantly expressed in response to stress or exercise and translocated to the nucleus, where it regulates the expression of stress adaptation-related genes with …
MOTS-c is a peptide encoded by the short open reading frame of the mitochondrial 12S rRNA gene. It is significantly expressed …
MOTS-c Functionally Prevents Metabolic Disorders.
Gao Y, Wei X, Wei P, Lu H, Zhong L, Tan J, Liu H, Liu Z. Gao Y, et al. Metabolites. 2023 Jan 13;13(1):125. doi: 10.3390/metabo13010125. Metabolites. 2023. PMID: 36677050 Free PMC article. Review.
Mitochondrial-derived peptides are a family of peptides encoded by short open reading frames in the mitochondrial genome, which have regulatory effects on mitochondrial functions, gene expression, and metabolic homeostasis of the body. As a new member of the mitochondrial- …
Mitochondrial-derived peptides are a family of peptides encoded by short open reading frames in the mitochondrial genome, which have regulat …
MOTS-C levels in individuals with and without obesity and its association with inflammation, insulin resistance and endothelial dysfunction.
Ozkaya DY, Haymana C, Demirci I, Duman UG, Küpçük E, Koç GE, Tasci I, Sonmez YA. Ozkaya DY, et al. Arch Endocrinol Metab. 2025 Sep 26;69(5):e250063. doi: 10.20945/2359-4292-2025-0063. Arch Endocrinol Metab. 2025. PMID: 41004666 Free PMC article.
Multiple regression analysis indicated that age and HOMA-IR were significant predictors of MOTS-c levels, with MOTS-c decreasing with age and increasing with higher insulin resistance. CONCLUSION: Serum MOTS-c levels were si …
Multiple regression analysis indicated that age and HOMA-IR were significant predictors of MOTS-c levels, with MOTS- …
Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals.
Cataldo LR, Fernández-Verdejo R, Santos JL, Galgani JE. Cataldo LR, et al. J Investig Med. 2018 Aug;66(6):1019-1022. doi: 10.1136/jim-2017-000681. Epub 2018 Mar 27. J Investig Med. 2018. PMID: 29593067
However, the effect of insulin resistance and obesity on plasma MOTS-c concentration in humans is unknown. To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with …
However, the effect of insulin resistance and obesity on plasma MOTS-c concentration in humans is unknown. To ga …
The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity.
Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P. Kim SJ, et al. Physiol Rep. 2019 Jul;7(13):e14171. doi: 10.14814/phy2.14171. Physiol Rep. 2019. PMID: 31293078 Free PMC article.
MOTS-c is an exercise mimetic and improves insulin sensitivity in aged and diet-induced obese mice. ...These results provide us a better understanding of the mechanism of how MOTS-c improves insulin sensitivity and reduces t …
MOTS-c is an exercise mimetic and improves insulin sensitivity in aged and diet-induced obese mice. ...These res …
MOTS-c: an equal opportunity insulin sensitizer.
Kim SJ, Miller B, Kumagai H, Yen K, Cohen P. Kim SJ, et al. J Mol Med (Berl). 2019 Apr;97(4):487-490. doi: 10.1007/s00109-019-01758-0. Epub 2019 Feb 20. J Mol Med (Berl). 2019. PMID: 30788534 Free PMC article. No abstract available.
Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.
Ramanjaneya M, Jerobin J, Bettahi I, Bensila M, Aye M, Siveen KS, Sathyapalan T, Skarulis M, Abou-Samra AB, Atkin SL. Ramanjaneya M, et al. Clin Endocrinol (Oxf). 2019 Aug;91(2):278-287. doi: 10.1111/cen.14007. Epub 2019 May 15. Clin Endocrinol (Oxf). 2019. PMID: 31066084
OBJECTIVE: Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder associated with mitochondrial dysfunction and insulin resistance (IR). MOTS-c, a mitochondrial peptide, promotes insulin sensitivity (IS) through activati …
OBJECTIVE: Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder associated with mitochondrial dysfunction and insulin …
49 results