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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1987 13
1988 23
1989 23
1990 27
1991 27
1992 19
1993 37
1994 22
1995 35
1996 26
1997 33
1998 29
1999 26
2000 24
2001 35
2002 12
2003 13
2004 10
2005 13
2006 14
2007 18
2008 17
2009 17
2010 27
2011 15
2012 17
2013 25
2014 36
2015 39
2016 29
2017 32
2018 35
2019 36
2020 48
2021 38
2022 27
2023 31
2024 39
2025 19
2026 12

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955 results

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Page 1
Species-specific cleavage of the autophagy adaptor p62 dictates responses to TNF.
Nössing C, Troitskaya O, Long JS, Craxton A, Brucoli M, Anderson E, Lilla S, McEwan DG, Minton AR, Barthet VJA, O'Prey J, Thomson G, Nixon C, Zanivan S, Strathdee D, MacFarlane M, Ryan KM. Nössing C, et al. Mol Cell. 2026 Apr 16;86(8):1574-1586.e11. doi: 10.1016/j.molcel.2026.03.013. Epub 2026 Apr 7. Mol Cell. 2026. PMID: 41950919 Free article.
Survey of the human proteostasis network: the ubiquitin-proteasome system.
Elsasser S, Powers ET, Stoeger T, Sui X, Kurtzbard RD, Martínez-Botía P, Wangeline MA, Gama AR, Huttlin EL, Elia LP, Kelly JW, Gestwicki JE, Frydman J, Finkbeiner S, Clerico EM, Morimoto RI, Prado MA, Vertegaal ACO, Hofmann K, Finley D. Elsasser S, et al. bioRxiv [Preprint]. 2026 Apr 30:2026.03.13.711689. doi: 10.64898/2026.03.13.711689. bioRxiv. 2026. PMID: 41890080 Free PMC article. Preprint.
Tumour-intrinsic features shape T cell differentiation through precursor to symptomatic multiple myeloma.
Foster KA, Rees E, Ainley L, Laidler A, Boyle EM, Lee L, Ward G, Galas-Filipowicz D, Fitzsimons E, Mikolajczak A, Lyon EJ, Jankovic D, Rahman J, Turakhia M, Mehta D, Garrod-Ketchley C, Uddin I, Beattie G, Hoade Y, Zhu C, Reading JL, Walker I, Chapman M, Ramasamy K, Herrero J, Chain B, Quezada SA, Yong KL. Foster KA, et al. Nat Commun. 2026 Feb 5;17(1):2400. doi: 10.1038/s41467-026-68718-4. Nat Commun. 2026. PMID: 41644568 Free PMC article.
Inhibiting translation elongation by reducing eIF5A activity induces feedback inhibition of initiation, limiting tumour cell proliferation.
Sfakianos AP, Raven RM, Smith T, Sun XM, Mulroney TE, Pizzinga M, Dezi V, Tenor AR, Stoneley M, Cole CH, Al-Doori K, Nur HA, Pennie RL, Powley I, Officer-Jones L, Sawarkar R, Turner M, MacFarlane M, Sansom OJ, Bushell M, Le Quesne J, Harvey RF, Willis AE. Sfakianos AP, et al. Nat Commun. 2025 Dec 13;16(1):11486. doi: 10.1038/s41467-025-66531-z. Nat Commun. 2025. PMID: 41390489 Free PMC article.
BMP9 knockout impairs pulmonary vessel muscularisation and confers aberrant tamoxifen sensitivity.
Dunmore BJ, Moore S, Jones RJ, Hodgson J, Auckland K, Southwood M, Figg N, Kikuchi N, Bennett M, Lawrie A, Rhodes CJ, Toshner MR, Gräf S, Li W, Morrell NW, Upton PD; UK National Cohort Study of Idiopathic and Heritable PAH Consortium; Uniphy Clinical Trials Network. Dunmore BJ, et al. Angiogenesis. 2025 Nov 12;29(1):5. doi: 10.1007/s10456-025-10017-5. Angiogenesis. 2025. PMID: 41222740 Free PMC article.
Altered translation elongation contributes to key hallmarks of aging in the killifish brain.
Di Fraia D, Marino A, Lee JH, Kelmer Sacramento E, Baumgart M, Bagnoli S, Balla T, Schalk F, Kamrad S, Guan R, Caterino C, Giannuzzi C, Tomaz da Silva P, Sahu AK, Gut H, Siano G, Tiessen M, Terzibasi-Tozzini E, Fornasiero EF, Gagneur J, Englert C, Patil KR, Correia-Melo C, Nedialkova DD, Frydman J, Cellerino A, Ori A. Di Fraia D, et al. Science. 2025 Jul 31;389(6759):eadk3079. doi: 10.1126/science.adk3079. Epub 2025 Jul 31. Science. 2025. PMID: 40743332
Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial.
Fennell DA, Hill K, Zhang M, Poile C, Ewings S, Baitei EY, Dzialo J, Nusrat N, Rogel J, Faulkner D, Ottensmeier C, Califano R, Hanna GG, Danson S, Steele N, Nye M, Johnson L, Mallard K, Lord J, Middleton C, Szlosarek P, Chan S, Darlison L, Wells-Jordan P, Richards C, Harber J, Bzura A, Spicer J, Pritchard C, Kamata T, Hahne JC, Jama M, Hollox EJ, Lester JF, Luo JL, Zhou Z, Yang H, Zhou H, Klampatsa A, Griffiths GO. Fennell DA, et al. Nat Commun. 2025 Jul 21;16(1):6688. doi: 10.1038/s41467-025-61691-4. Nat Commun. 2025. PMID: 40691143 Free PMC article. Clinical Trial.
Impact of Amerindian ancestry on clinical outcomes in Crohn's disease and ulcerative colitis in a Latino population.
Pérez-Jeldres T, Bustamante ML, Alvares D, Alvarez-Lobos M, Kalmer L, Azocar L, Melero RS, Ascui G, Aguilar N, Estela R, Hernández-Rocha C, Candia R, González M, Silva V, De La Vega A, Arriagada E, Serrano CA, Pávez-Ovalle C, Quinteros CM, Miquel JF, Alex DG. Pérez-Jeldres T, et al. Sci Rep. 2025 May 2;15(1):15331. doi: 10.1038/s41598-025-99543-2. Sci Rep. 2025. PMID: 40316706 Free PMC article.
Developmental mitochondrial complex I activity determines lifespan.
Stefanatos R, Robertson F, Castejon-Vega B, Yu Y, Uribe AH, Myers K, Kataura T, Korolchuk VI, Maddocks ODK, Martins LM, Sanz A. Stefanatos R, et al. EMBO Rep. 2025 Apr;26(8):1957-1983. doi: 10.1038/s44319-025-00416-6. Epub 2025 Mar 17. EMBO Rep. 2025. PMID: 40097814 Free PMC article.
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR).
Loughran G, Andreev DE, Terenin IM, Namy O, Mikl M, Yordanova MM, McManus CJ, Firth AE, Atkins JF, Fraser CS, Ignatova Z, Iwasaki S, Kufel J, Larsson O, Leidel SA, Mankin AS, Mariotti M, Tanenbaum ME, Topisirovic I, Vázquez-Laslop N, Viero G, Caliskan N, Chen Y, Clark PL, Dinman JD, Farabaugh PJ, Gilbert WV, Ivanov P, Kieft JS, Mühlemann O, Sachs MS, Shatsky IN, Sonenberg N, Steckelberg AL, Willis AE, Woodside MT, Valasek LS, Dmitriev SE, Baranov PV. Loughran G, et al. Nat Struct Mol Biol. 2025 Mar;32(3):418-430. doi: 10.1038/s41594-025-01492-x. Epub 2025 Mar 3. Nat Struct Mol Biol. 2025. PMID: 40033152 Free PMC article. Review.
Let's (P-s)talk about specialized ribosomes.
Harvey RF, Pöyry T, Willis AE. Harvey RF, et al. Mol Cell. 2024 Dec 5;84(23):4478-4479. doi: 10.1016/j.molcel.2024.11.011. Mol Cell. 2024. PMID: 39642853 Free article.
Publisher Correction: Novel immunotherapeutics against LGR5 to target multiple cancer types.
Chen HC, Mueller N, Stott K, Kapeni C, Rivers E, Sauer CM, Beke F, Walsh SJ, Ashman N, O'Brien L, Rafati Fard A, Ghodsinia A, Li C, Joud F, Giger O, Zlobec I, Olan I, Aitken SJ, Hoare M, Mair R, Serrao E, Brenton JD, Garcia-Gimenez A, Richardson SE, Huntly B, Spring DR, Skjoedt MO, Skjødt K, de la Roche M, de la Roche M. Chen HC, et al. EMBO Mol Med. 2024 Nov;16(11):3026. doi: 10.1038/s44321-024-00139-6. EMBO Mol Med. 2024. PMID: 39322863 Free PMC article.
Novel immunotherapeutics against LGR5 to target multiple cancer types.
Chen HC, Mueller N, Stott K, Kapeni C, Rivers E, Sauer CM, Beke F, Walsh SJ, Ashman N, O'Brien L, Rafati Fard A, Ghodsinia A, Li C, Joud F, Giger O, Zlobec I, Olan I, Aitken SJ, Hoare M, Mair R, Serrao E, Brenton JD, Garcia-Gimenez A, Richardson SE, Huntly B, Spring DR, Skjoedt MO, Skjødt K, de la Roche M, de la Roche M. Chen HC, et al. EMBO Mol Med. 2024 Sep;16(9):2233-2261. doi: 10.1038/s44321-024-00121-2. Epub 2024 Aug 21. EMBO Mol Med. 2024. PMID: 39169164 Free PMC article.
Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells.
Fischer K, Lulla A, So TY, Pereyra-Gerber P, Raybould MIJ, Kohler TN, Yam-Puc JC, Kaminski TS, Hughes R, Pyeatt GL, Leiss-Maier F, Brear P, Matheson NJ, Deane CM, Hyvönen M, Thaventhiran JED, Hollfelder F. Fischer K, et al. Nat Biotechnol. 2025 Jun;43(6):960-970. doi: 10.1038/s41587-024-02346-5. Epub 2024 Aug 14. Nat Biotechnol. 2025. PMID: 39143416 Free PMC article.
VAMP2 regulates phase separation of α-synuclein.
Agarwal A, Chandran A, Raza F, Ungureanu IM, Hilcenko C, Stott K, Bright NA, Morone N, Warren AJ, Lautenschläger J. Agarwal A, et al. Nat Cell Biol. 2024 Aug;26(8):1296-1308. doi: 10.1038/s41556-024-01451-6. Epub 2024 Jul 1. Nat Cell Biol. 2024. PMID: 38951707 Free PMC article.
The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling.
Schmidt A, Hrupka B, van Bebber F, Sunil Kumar S, Feng X, Tschirner SK, Aßfalg M, Müller SA, Hilger LS, Hofmann LI, Pigoni M, Jocher G, Voytyuk I, Self EL, Ito M, Hyakkoku K, Yoshimura A, Horiguchi N, Feederle R, De Strooper B, Schulte-Merker S, Lammert E, Moechars D, Schmid B, Lichtenthaler SF. Schmidt A, et al. J Clin Invest. 2024 Jun 18;134(16):e170550. doi: 10.1172/JCI170550. J Clin Invest. 2024. PMID: 38888964 Free PMC article.
An optimised patient-derived explant platform for breast cancer reflects clinical responses to chemotherapy and antibody-directed therapy.
Demetriou C, Abid N, Butterworth M, Lezina L, Sandhu P, Howells L, Powley IR, Pringle JH, Sidat Z, Qassid O, Purnell D, Kaushik M, Duckworth K, Hartshorn H, Thomas A, Shaw JA, MacFarlane M, Pritchard C, Miles GJ. Demetriou C, et al. Sci Rep. 2024 Jun 4;14(1):12833. doi: 10.1038/s41598-024-63170-0. Sci Rep. 2024. PMID: 38834809 Free PMC article.
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.
Mannion J, Gifford V, Bellenie B, Fernando W, Ramos Garcia L, Wilson R, John SW, Udainiya S, Patin EC, Tiu C, Smith A, Goicoechea M, Craxton A, Moraes de Vasconcelos N, Guppy N, Cheung KJ, Cundy NJ, Pierrat O, Brennan A, Roumeliotis TI, Benstead-Hume G, Alexander J, Muirhead G, Layzell S, Lyu W, Roulstone V, Allen M, Baldock H, Legrand A, Gabel F, Serrano-Aparicio N, Starling C, Guo H, Upton J, Gyrd-Hansen M, MacFarlane M, Seddon B, Raynaud F, Roxanis I, Harrington K, Haider S, Choudhary JS, Hoelder S, Tenev T, Meier P. Mannion J, et al. Immunity. 2024 Jul 9;57(7):1514-1532.e15. doi: 10.1016/j.immuni.2024.04.025. Epub 2024 May 23. Immunity. 2024. PMID: 38788712 Free PMC article.
955 results