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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1975 1
1976 1
1977 1
1978 5
1979 2
1980 6
1981 10
1982 3
1983 10
1984 19
1985 26
1986 25
1987 25
1988 27
1989 34
1990 26
1991 49
1992 43
1993 37
1994 37
1995 64
1996 44
1997 50
1998 47
1999 69
2000 64
2001 51
2002 67
2003 46
2004 65
2005 71
2006 68
2007 72
2008 87
2009 83
2010 79
2011 76
2012 101
2013 93
2014 91
2015 69
2016 77
2017 74
2018 62
2019 58
2020 58
2021 72
2022 41
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2,130 results
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Page 1
Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification.
Parker MT, Knop K, Sherwood AV, Schurch NJ, Mackinnon K, Gould PD, Hall AJ, Barton GJ, Simpson GG. Parker MT, et al. Elife. 2020 Jan 14;9:e49658. doi: 10.7554/eLife.49658. Elife. 2020. PMID: 31931956 Free PMC article.
Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and …
Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We …
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing.
Martinez NM, Su A, Burns MC, Nussbacher JK, Schaening C, Sathe S, Yeo GW, Gilbert WV. Martinez NM, et al. Mol Cell. 2022 Feb 3;82(3):645-659.e9. doi: 10.1016/j.molcel.2021.12.023. Epub 2022 Jan 19. Mol Cell. 2022. PMID: 35051350
In vitro splicing assays establish a direct effect of individual endogenous pre-mRNA pseudouridines on splicing efficiency. We validate hundreds of pre-mRNA sites as direct targets of distinct pseudouridine synthases and show that PUS1, PUS7, and RPUSD4-three pre- …
In vitro splicing assays establish a direct effect of individual endogenous pre-mRNA pseudouridines on splicing efficiency. We valida …
Alternative cleavage and polyadenylation in health and disease.
Gruber AJ, Zavolan M. Gruber AJ, et al. Nat Rev Genet. 2019 Oct;20(10):599-614. doi: 10.1038/s41576-019-0145-z. Epub 2019 Jul 2. Nat Rev Genet. 2019. PMID: 31267064 Review.
Most human genes have multiple sites at which RNA 3' end cleavage and polyadenylation can occur, enabling the expression of distinct transcript isoforms under different conditions. Novel methods to sequence RNA 3' ends have generated comp …
Most human genes have multiple sites at which RNA 3' end cleavage and polyadenylation can occur, enabling the expressio …
Roles of Sumoylation in mRNA Processing and Metabolism.
Richard P, Vethantham V, Manley JL. Richard P, et al. Adv Exp Med Biol. 2017;963:15-33. doi: 10.1007/978-3-319-50044-7_2. Adv Exp Med Biol. 2017. PMID: 28197904 Free PMC article. Review.
SUMO has gained prominence as a regulator in a number of cellular processes. The roles of sumoylation in RNA metabolism, however, while considerable, remain less well understood. ...Possible regulatory roles for SUMO have emerged in pre-mRNA 3' …
SUMO has gained prominence as a regulator in a number of cellular processes. The roles of sumoylation in RNA metabolism
Mechanistic insights into mRNA 3'-end processing.
Kumar A, Clerici M, Muckenfuss LM, Passmore LA, Jinek M. Kumar A, et al. Curr Opin Struct Biol. 2019 Dec;59:143-150. doi: 10.1016/j.sbi.2019.08.001. Epub 2019 Sep 6. Curr Opin Struct Biol. 2019. PMID: 31499460 Free PMC article. Review.
The polyadenosine (poly(A)) tail found on the 3'-end of almost all eukaryotic mRNAs is important for mRNA stability and regulation of translation. mRNA 3'-end processing occurs co-transcriptionally and involves more than 20 protein …
The polyadenosine (poly(A)) tail found on the 3'-end of almost all eukaryotic mRNAs is important for mRNA stability and …
Dynamics in Fip1 regulate eukaryotic mRNA 3' end processing.
Kumar A, Yu CWH, Rodríguez-Molina JB, Li XH, Freund SMV, Passmore LA. Kumar A, et al. Genes Dev. 2021 Nov 1;35(21-22):1510-1526. doi: 10.1101/gad.348671.121. Epub 2021 Sep 30. Genes Dev. 2021. PMID: 34593603 Free PMC article.
Cleavage and polyadenylation factor (CPF/CPSF) is a multiprotein complex essential for mRNA 3' end processing in eukaryotes. It contains an endonuclease that cleaves pre-mRNAs, and a polymerase that adds a poly(A) tail onto the cleaved 3' end
Cleavage and polyadenylation factor (CPF/CPSF) is a multiprotein complex essential for mRNA 3' end processing in …
Reciprocal Links between Pre-messenger RNA 3'-End Processing and Genome Stability.
Dutertre M, Sfaxi R, Vagner S. Dutertre M, et al. Trends Biochem Sci. 2021 Jul;46(7):579-594. doi: 10.1016/j.tibs.2021.01.009. Epub 2021 Feb 28. Trends Biochem Sci. 2021. PMID: 33653631 Review.
The 3'-end processing of most pre-messenger RNAs (pre-mRNAs) involves RNA cleavage and polyadenylation and is coupled to transcription termination. In both yeast and human cells, pre-mRNA 3'-end cleavage is globally inhibite …
The 3'-end processing of most pre-messenger RNAs (pre-mRNAs) involves RNA cleavage and polyadenylation an …
mRNA 3' end processing and more--multiple functions of mammalian cleavage factor I-68.
Ruepp MD, Schümperli D, Barabino SM. Ruepp MD, et al. Wiley Interdiscip Rev RNA. 2011 Jan-Feb;2(1):79-91. doi: 10.1002/wrna.35. Wiley Interdiscip Rev RNA. 2011. PMID: 21956970 Review.
The formation of defined 3(') ends is an important step in the biogenesis of mRNAs. In eukaryotic cells, all mRNA 3(') ends are generated by endonucleolytic cleavage of primary transcripts in reactions that are essentially posttranscriptional. . …
The formation of defined 3(') ends is an important step in the biogenesis of mRNAs. In eukaryotic cells, all mRNA 3
Widespread Influence of 3'-End Structures on Mammalian mRNA Processing and Stability.
Wu X, Bartel DP. Wu X, et al. Cell. 2017 May 18;169(5):905-917.e11. doi: 10.1016/j.cell.2017.04.036. Cell. 2017. PMID: 28525757 Free PMC article.
Analyses of thousands of ectopically expressed variants demonstrate that this folding both enhances processing and increases mRNA metabolic stability. Even folds with predicted stabilities resembling those of random sequences can enhance processing. St …
Analyses of thousands of ectopically expressed variants demonstrate that this folding both enhances processing and increases mRNA
3' end mRNA processing: molecular mechanisms and implications for health and disease.
Danckwardt S, Hentze MW, Kulozik AE. Danckwardt S, et al. EMBO J. 2008 Feb 6;27(3):482-98. doi: 10.1038/sj.emboj.7601932. EMBO J. 2008. PMID: 18256699 Free PMC article. Review.
Recent advances in the understanding of the molecular mechanism of mRNA 3' end processing have uncovered a previously unanticipated integrated network of transcriptional and RNA-processing mechanisms. A variety of human diseases impressiv …
Recent advances in the understanding of the molecular mechanism of mRNA 3' end processing have uncovered a previ …
2,130 results