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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1975 1
1976 1
1977 1
1978 5
1979 2
1980 6
1981 10
1982 3
1983 10
1984 19
1985 26
1986 25
1987 25
1988 27
1989 34
1990 26
1991 49
1992 43
1993 37
1994 37
1995 64
1996 44
1997 50
1998 47
1999 69
2000 64
2001 51
2002 67
2003 46
2004 65
2005 71
2006 68
2007 72
2008 87
2009 83
2010 79
2011 76
2012 101
2013 93
2014 91
2015 69
2016 77
2017 74
2018 62
2019 58
2020 58
2021 73
2022 58
2023 57
2024 55
2025 8

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2,256 results

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Page 1
Modulation of mRNA 3'-End Processing and Transcription Termination in Virus-Infected Cells.
Vijayakumar A, Park A, Steitz JA. Vijayakumar A, et al. Front Immunol. 2022 Feb 10;13:828665. doi: 10.3389/fimmu.2022.828665. eCollection 2022. Front Immunol. 2022. PMID: 35222412 Free PMC article. Review.
Eukaryotic mRNA 3-end processing is a multi-step process beginning with pre-mRNA transcript cleavage followed by poly(A) tail addition. Closely coupled to transcription termination, 3-end processing is a critical step …
Eukaryotic mRNA 3-end processing is a multi-step process beginning with pre-mRNA transcript cleava …
3'-end mRNA processing within apicomplexan parasites, a patchwork of classic, and unexpected players.
Swale C, Hakimi MA. Swale C, et al. Wiley Interdiscip Rev RNA. 2023 Sep-Oct;14(5):e1783. doi: 10.1002/wrna.1783. Epub 2023 Mar 30. Wiley Interdiscip Rev RNA. 2023. PMID: 36994829 Review.
The 3'-end processing of mRNA is a co-transcriptional process that leads to the formation of a poly-adenosine tail on the mRNA and directly controls termination of the RNA polymerase II juggernaut. ...This feature, inherited from t …
The 3'-end processing of mRNA is a co-transcriptional process that leads to the formation of a poly-adeno …
UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells.
Heller-Trulli D, Liu H, Mukherjee S, Moore CL. Heller-Trulli D, et al. Mol Cell Biol. 2022 Dec 15;42(12):e0017422. doi: 10.1128/mcb.00174-22. Epub 2022 Dec 15. Mol Cell Biol. 2022. PMID: 36519931 Free PMC article.
Consistent with previous studies in other cell types, Ube3d knockout leads to decreased levels of CPSF73 and global changes in cellular mRNAs indicative of a loss of 3'-end processing capacity. Ube3d knockout cells also display decreased expression of known p …
Consistent with previous studies in other cell types, Ube3d knockout leads to decreased levels of CPSF73 and global changes in cellular mRNA …
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing.
Martinez NM, Su A, Burns MC, Nussbacher JK, Schaening C, Sathe S, Yeo GW, Gilbert WV. Martinez NM, et al. Mol Cell. 2022 Feb 3;82(3):645-659.e9. doi: 10.1016/j.molcel.2021.12.023. Epub 2022 Jan 19. Mol Cell. 2022. PMID: 35051350 Free PMC article.
In vitro splicing assays establish a direct effect of individual endogenous pre-mRNA pseudouridines on splicing efficiency. We validate hundreds of pre-mRNA sites as direct targets of distinct pseudouridine synthases and show that PUS1, PUS7, and RPUSD4-three pre- …
In vitro splicing assays establish a direct effect of individual endogenous pre-mRNA pseudouridines on splicing efficiency. We valida …
mRNA 3' end processing and more--multiple functions of mammalian cleavage factor I-68.
Ruepp MD, Schümperli D, Barabino SM. Ruepp MD, et al. Wiley Interdiscip Rev RNA. 2011 Jan-Feb;2(1):79-91. doi: 10.1002/wrna.35. Wiley Interdiscip Rev RNA. 2011. PMID: 21956970 Review.
The formation of defined 3(') ends is an important step in the biogenesis of mRNAs. In eukaryotic cells, all mRNA 3(') ends are generated by endonucleolytic cleavage of primary transcripts in reactions that are essentially posttranscriptional. . …
The formation of defined 3(') ends is an important step in the biogenesis of mRNAs. In eukaryotic cells, all mRNA 3
Mature mRNA processing that deletes 3' end sequences directs translational activation and embryonic development.
Takada Y, Fierro L, Sato K, Sanada T, Ishii A, Yamamoto T, Kotani T. Takada Y, et al. Sci Adv. 2023 Nov 24;9(47):eadg6532. doi: 10.1126/sciadv.adg6532. Epub 2023 Nov 24. Sci Adv. 2023. PMID: 38000026 Free PMC article.
Here, we report a previously unknown RNA processing of 3' end sequences of mature mRNAs that activates the translation of stored mRNAs. ...Identification of proteins binding to unprocessed and/or processed mRNAs revealed that mRNA shorten …
Here, we report a previously unknown RNA processing of 3' end sequences of mature mRNAs that activates the trans …
Alternative cleavage and polyadenylation in health and disease.
Gruber AJ, Zavolan M. Gruber AJ, et al. Nat Rev Genet. 2019 Oct;20(10):599-614. doi: 10.1038/s41576-019-0145-z. Epub 2019 Jul 2. Nat Rev Genet. 2019. PMID: 31267064 Review.
Most human genes have multiple sites at which RNA 3' end cleavage and polyadenylation can occur, enabling the expression of distinct transcript isoforms under different conditions. Novel methods to sequence RNA 3' ends have generated comp …
Most human genes have multiple sites at which RNA 3' end cleavage and polyadenylation can occur, enabling the expressio …
Mpe1 senses the binding of pre-mRNA and controls 3' end processing by CPF.
Rodríguez-Molina JB, O'Reilly FJ, Fagarasan H, Sheekey E, Maslen S, Skehel JM, Rappsilber J, Passmore LA. Rodríguez-Molina JB, et al. Mol Cell. 2022 Jul 7;82(13):2490-2504.e12. doi: 10.1016/j.molcel.2022.04.021. Epub 2022 May 17. Mol Cell. 2022. PMID: 35584695 Free PMC article.
Most eukaryotic messenger RNAs (mRNAs) are processed at their 3' end by the cleavage and polyadenylation specificity factor (CPF/CPSF). ...Together, our data suggest that Mpe1 plays a major role in accurate 3' end processing, activ …
Most eukaryotic messenger RNAs (mRNAs) are processed at their 3' end by the cleavage and polyadenylation specifi …
Mechanistic insights into mRNA 3'-end processing.
Kumar A, Clerici M, Muckenfuss LM, Passmore LA, Jinek M. Kumar A, et al. Curr Opin Struct Biol. 2019 Dec;59:143-150. doi: 10.1016/j.sbi.2019.08.001. Epub 2019 Sep 6. Curr Opin Struct Biol. 2019. PMID: 31499460 Free PMC article. Review.
The polyadenosine (poly(A)) tail found on the 3'-end of almost all eukaryotic mRNAs is important for mRNA stability and regulation of translation. mRNA 3'-end processing occurs co-transcriptionally and involves more than 20 protein …
The polyadenosine (poly(A)) tail found on the 3'-end of almost all eukaryotic mRNAs is important for mRNA stability and …
3' end mRNA processing: molecular mechanisms and implications for health and disease.
Danckwardt S, Hentze MW, Kulozik AE. Danckwardt S, et al. EMBO J. 2008 Feb 6;27(3):482-98. doi: 10.1038/sj.emboj.7601932. EMBO J. 2008. PMID: 18256699 Free PMC article. Review.
Recent advances in the understanding of the molecular mechanism of mRNA 3' end processing have uncovered a previously unanticipated integrated network of transcriptional and RNA-processing mechanisms. A variety of human diseases impressiv …
Recent advances in the understanding of the molecular mechanism of mRNA 3' end processing have uncovered a previ …
2,256 results