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832 results

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Page 1
LC-MS/MS quantitation of non-psychotropic cannabinoid cannabidiol in aqueous humor.
Aebersold AS, Kumar A, Song ZH. Aebersold AS, et al. J Pharm Biomed Anal. 2023 May 10;228:115324. doi: 10.1016/j.jpba.2023.115324. Epub 2023 Mar 5. J Pharm Biomed Anal. 2023. PMID: 36907022 Free PMC article.
Cannabidiol (CBD) is the most abundant non-psychotropic phytocannabinoid isolated from Cannabis sativa. ...The development and validation of this LC-MS/MS method is an important step toward the goal of assessing the aqueous humor concentrations of CBD and cor …
Cannabidiol (CBD) is the most abundant non-psychotropic phytocannabinoid isolated from Cannabis sativa. ...The development and valida …
Cannabidiol Gummy Products: LC-MS/MS Assessment of Cannabinoid Concentrations.
Johnson ED, Kilgore MW, Stafford M, Randolph M, Glover M, Babalonis S. Johnson ED, et al. Cannabis Cannabinoid Res. 2025 Dec;10(6):710-718. doi: 10.1089/can.2024.0167. Epub 2025 Jun 2. Cannabis Cannabinoid Res. 2025. PMID: 40454463
Background: Hemp and cannabidiol (CBD) products are now widely available for purchase in the United States and in many international jurisdictions. ...Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used for cannabinoid analysis. Key outcome mea …
Background: Hemp and cannabidiol (CBD) products are now widely available for purchase in the United States and in many international …
Balancing risks and benefits of cannabis use: umbrella review of meta-analyses of randomised controlled trials and observational studies.
Solmi M, De Toffol M, Kim JY, Choi MJ, Stubbs B, Thompson T, Firth J, Miola A, Croatto G, Baggio F, Michelon S, Ballan L, Gerdle B, Monaco F, Simonato P, Scocco P, Ricca V, Castellini G, Fornaro M, Murru A, Vieta E, Fusar-Poli P, Barbui C, Ioannidis JPA, Carvalho AF, Radua J, Correll CU, Cortese S, Murray RM, Castle D, Shin JI, Dragioti E. Solmi M, et al. BMJ. 2023 Aug 30;382:e072348. doi: 10.1136/bmj-2022-072348. BMJ. 2023. PMID: 37648266 Free PMC article.
For chronic pain, cannabis based medicines or cannabinoids reduced pain by 30% (0.59 (0.37 to 0.93), GRADE=high), across different conditions (n=7), but increased psychological distress. For epilepsy, cannabidiol increased risk of diarrhoea (2.25 (1.33 to 3.81)), had no ef …
For chronic pain, cannabis based medicines or cannabinoids reduced pain by 30% (0.59 (0.37 to 0.93), GRADE=high), across different condition …
LC-MS/MS-Based Concurrent Quantification of Cannabidiol and Melatonin in Mouse Plasma to Elucidate Complex PK Interactions.
Wang M, Zhang W, Wu X, Wang L, Li C, Liu C, Zhuang X. Wang M, et al. Pharmaceutics. 2024 Nov 25;16(12):1511. doi: 10.3390/pharmaceutics16121511. Pharmaceutics. 2024. PMID: 39771491 Free PMC article.
Objective: This study aimed to develop a quantitative analytical method for the simultaneous determination of cannabidiol (CBD) and melatonin (MT) in mouse plasma using the protein precipitation method coupled with LC-MS/MS. ...The AUC of CBD was positively c …
Objective: This study aimed to develop a quantitative analytical method for the simultaneous determination of cannabidiol (CBD) and m …
LC-MS/MS Assay for the Measurement of Cannabidiol Profiling in CBD Oil from Japanese Market and Application for Convertible Tetrahydrocannabinol in Acetic Acid Condition.
Takashina S, Takahashi M, Morimoto K, Inoue K. Takashina S, et al. Chem Pharm Bull (Tokyo). 2022;70(2):169-174. doi: 10.1248/cpb.c21-00901. Chem Pharm Bull (Tokyo). 2022. PMID: 35110438 Free article.
In this study, a routine assay for evaluating CBD oil samples was performed using LC coupled with tandem mass spectrometry (LC-MS/MS) and was used to apply the convertible tetrahydrocannabinol (THC) in acetic acid conditions. ...Following that, we investigated the c …
In this study, a routine assay for evaluating CBD oil samples was performed using LC coupled with tandem mass spectrometry (LC-MS/ …
11-Nor-9-Carboxy-delta8-Tetrahydrocannabinol, 7-Carboxy Cannabidiol, and 11-Nor-9-Carboxy-delta9-Tetrahydrocannabinol in Urine by LC-MS/MS.
Hughs ML, McMillin GA. Hughs ML, et al. Methods Mol Biol. 2024;2737:161-174. doi: 10.1007/978-1-0716-3541-4_16. Methods Mol Biol. 2024. PMID: 38036820
delta8-Tetrahydrocannabinol (delta8-THC) and cannabidiol (CBD) are increasingly popular cannabinoids. Measuring metabolites in urine is an important tool for detecting use and/or exposure as well as for monitoring elimination of these two drugs. ...Here, we present a metho …
delta8-Tetrahydrocannabinol (delta8-THC) and cannabidiol (CBD) are increasingly popular cannabinoids. Measuring metabolites in urine …
Innovative LC-MS/MS method for therapeutic drug monitoring of fenfluramine and cannabidiol in the plasma of pediatric patients with epilepsy.
Pigliasco F, Cafaro A, Barco S, Stella M, Mattioli F, Riva A, Mancardi MM, Lattanzi S, Bandettini R, Striano P, Cangemi G. Pigliasco F, et al. J Pharm Biomed Anal. 2024 Aug 1;245:116174. doi: 10.1016/j.jpba.2024.116174. Epub 2024 Apr 23. J Pharm Biomed Anal. 2024. PMID: 38703746
We present a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantifying fenfluramine (FFA), its active metabolite norfenfluramine (norFFA), and Epidyolex , a pure cannabidiol (CBD) oral solution in plasma. ...The Thermofisher Quant …
We present a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantifying fenfluramine (FFA), its ac …
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years.
Maccarrone M, Di Marzo V, Gertsch J, Grether U, Howlett AC, Hua T, Makriyannis A, Piomelli D, Ueda N, van der Stelt M. Maccarrone M, et al. Pharmacol Rev. 2023 Sep;75(5):885-958. doi: 10.1124/pharmrev.122.000600. Epub 2023 May 10. Pharmacol Rev. 2023. PMID: 37164640 Free PMC article. Review.
Compelling research evidence and the Food and Drug Administration cannabis-derived cannabidiol approval for severe childhood epilepsy have confirmed the large therapeutic potential of cannabidiol itself, delta(9)-tetrahydrocannabinol and other plant-derived cannabin …
Compelling research evidence and the Food and Drug Administration cannabis-derived cannabidiol approval for severe childhood epilepsy …
Development of an UHPLC-MS/MS method to determine cutaneous biodistribution of cannabidiol after topical application of cannabidiol gel assisted by iontophoresis.
Kang D, Wang C, Liu W, Yang M, Cheng X, Chen Y. Kang D, et al. Biomed Chromatogr. 2023 Nov;37(11):e5735. doi: 10.1002/bmc.5735. Epub 2023 Aug 31. Biomed Chromatogr. 2023. PMID: 37651752
However, currently existing quantification methods for the investigation of cannabidiol skin distribution are not optimal. This study aimed to establish a method for the determination of cannabidiol in skin samples by UHPLC-MS/MS. ...A cryo-sectioning …
However, currently existing quantification methods for the investigation of cannabidiol skin distribution are not optimal. This study …
UHPLC-MS/MS analysis of cannabidiol metabolites in serum and urine samples. Application to an individual treated with medical cannabis.
Pichini S, Malaca S, Gottardi M, Pérez-Acevedo AP, Papaseit E, Perez-Maña C, Farré M, Pacifici R, Tagliabracci A, Mannocchi G, Busardò FP. Pichini S, et al. Talanta. 2021 Feb 1;223(Pt 2):121772. doi: 10.1016/j.talanta.2020.121772. Epub 2020 Oct 14. Talanta. 2021. PMID: 33298281
We developed and validated a method using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) for quantifying cannabidiol (CBD) and its metabolites, cannabidiol-7-oic acid (7-COOH-CBD), 7- hydroxycannabidiol …
We developed and validated a method using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS …
832 results