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Page 1
Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement.
Butawan M, Benjamin RL, Bloomer RJ. Butawan M, et al. Nutrients. 2017 Mar 16;9(3):290. doi: 10.3390/nu9030290. Nutrients. 2017. PMID: 28300758 Free PMC article. Review.
Methylsulfonylmethane (MSM) has become a popular dietary supplement used for a variety of purposes, including its most common use as an anti-inflammatory agent. ...A variety of health-specific outcome measures are improved with MSM supplementation, including inflamm …
Methylsulfonylmethane (MSM) has become a popular dietary supplement used for a variety of purposes, including its most common use as …
Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.
Toguchi A, Noguchi N, Kanno T, Yamada A. Toguchi A, et al. Nutrients. 2023 Jun 30;15(13):2995. doi: 10.3390/nu15132995. Nutrients. 2023. PMID: 37447322 Free PMC article. Clinical Trial.
We conducted a randomized, double-blind, placebo-controlled trial of oral consumption of MSM on mild pain of the knee joint in healthy Japanese participants. A total of 88 participants were enrolled in this study and randomly assigned to MSM consumptio …
We conducted a randomized, double-blind, placebo-controlled trial of oral consumption of MSM on mild pain of the knee joint …
Patisiran Treatment in Patients with Transthyretin Cardiac Amyloidosis.
Maurer MS, Kale P, Fontana M, Berk JL, Grogan M, Gustafsson F, Hung RR, Gottlieb RL, Damy T, González-Duarte A, Sarswat N, Sekijima Y, Tahara N, Taylor MS, Kubanek M, Donal E, Palecek T, Tsujita K, Tang WHW, Yu WC, Obici L, Simões M, Fernandes F, Poulsen SH, Diemberger I, Perfetto F, Solomon SD, Di Carli M, Badri P, White MT, Chen J, Yureneva E, Sweetser MT, Jay PY, Garg PP, Vest J, Gillmore JD; APOLLO-B Trial Investigators. Maurer MS, et al. N Engl J Med. 2023 Oct 26;389(17):1553-1565. doi: 10.1056/NEJMoa2300757. N Engl J Med. 2023. PMID: 37888916 Free PMC article. Clinical Trial.
Significant benefits were not observed for the second secondary end point. Infusion-related reactions, arthralgia, and muscle spasms occurred more often among patients in the patisiran group than among those in the placebo group. ...
Significant benefits were not observed for the second secondary end point. Infusion-related reactions, arthralgia, and muscle spasms …
Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis.
Frydendal T, Christensen R, Mechlenburg I, Mikkelsen LR, Varnum C, Graversen AE, Kjærsgaard-Andersen P, Revald PH, Hofbauer C, Bieder MJ, Qassim H, Munir MS, Jakobsen SS, Nielsen SM, Ingwersen KG, Overgaard S. Frydendal T, et al. N Engl J Med. 2024 Oct 31;391(17):1610-1620. doi: 10.1056/NEJMoa2400141. N Engl J Med. 2024. PMID: 39476341 Clinical Trial.
The primary outcome was the change in patient-reported hip pain and function from baseline to 6 months after the initiation of treatment, assessed with the use of the Oxford Hip Score (range, 0 to 48, with higher scores indicating less pain and better function). ... …
The primary outcome was the change in patient-reported hip pain and function from baseline to 6 months after the initiation of treatm …
Efficacy of dietary supplements for treating knee osteoarthritis: a systematic review and network meta-analysis.
Du P, Ajia A, Xiang Z, Zheng S, Hu C, Wang P. Du P, et al. Front Nutr. 2025 Mar 7;12:1556133. doi: 10.3389/fnut.2025.1556133. eCollection 2025. Front Nutr. 2025. PMID: 40123938 Free PMC article.
PURPOSE: This study aims to ascertain the most efficacious dietary supplement for KOA, with a specific focus on reducing pain, alleviating stiffness, and enhancing joint function. METHODS: We conducted an exhaustive search of multiple databases, including PubMed, We …
PURPOSE: This study aims to ascertain the most efficacious dietary supplement for KOA, with a specific focus on reducing pain, allevi …
Evaluation of the Effect of Mega MSM on Improving Joint Function in Populations Experiencing Joint Degeneration.
Xu G, Zhou T, Gu Y, Wang Q, Shariff M, Gu P, Nguyen T, Shi R, Rao J. Xu G, et al. Int J Biomed Sci. 2015 Jun;11(2):54-60. Int J Biomed Sci. 2015. PMID: 26199577 Free PMC article.
Joint degeneration has become a commonplace problem in aging populations. The main clinical manifestations include joint pain, joint stiffness and joint swelling with functional disorder. Mega MSM is a nutritional supplement that may prov …
Joint degeneration has become a commonplace problem in aging populations. The main clinical manifestations include joint pa …
[Combination therapy for exacerbations of pain in osteoarthritis with non-fixed combinations].
Naumov AV, Unkovskiy AV, Khovasova NO, Fokeev DK, Kolesnikova AV. Naumov AV, et al. Ter Arkh. 2025 Jun 8;97(5):419-426. doi: 10.26442/00403660.2025.05.203272. Ter Arkh. 2025. PMID: 40561485 Clinical Trial. Russian.
Participants were randomized into two groups: Group A (n=30) received CS/GL/MSM/HA, while Group B (n=30) received the same regimen supplemented with collagen. Pain dynamics (VAS, WOMAC), NSAID requirements, and functional outcomes (Timed Up-and-Go test, walking spee …
Participants were randomized into two groups: Group A (n=30) received CS/GL/MSM/HA, while Group B (n=30) received the same regimen su …
Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial.
Withee ED, Tippens KM, Dehen R, Tibbitts D, Hanes D, Zwickey H. Withee ED, et al. J Int Soc Sports Nutr. 2017 Jul 21;14:24. doi: 10.1186/s12970-017-0181-z. eCollection 2017. J Int Soc Sports Nutr. 2017. PMID: 28736511 Free PMC article. Clinical Trial.
Time-by-treatment results did not reach statistical significance for any outcome measure, however, the MSM group saw clinically significant (delta > 10 mm) reductions in both muscle and joint pain. ...MSM supplementation attenuated post-exercise mus …
Time-by-treatment results did not reach statistical significance for any outcome measure, however, the MSM group saw clinically signi …
50 results