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Page 1
Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma.
Motzer RJ, Tannir NM, McDermott DF, Arén Frontera O, Melichar B, Choueiri TK, Plimack ER, Barthélémy P, Porta C, George S, Powles T, Donskov F, Neiman V, Kollmannsberger CK, Salman P, Gurney H, Hawkins R, Ravaud A, Grimm MO, Bracarda S, Barrios CH, Tomita Y, Castellano D, Rini BI, Chen AC, Mekan S, McHenry MB, Wind-Rotolo M, Doan J, Sharma P, Hammers HJ, Escudier B; CheckMate 214 Investigators. Motzer RJ, et al. N Engl J Med. 2018 Apr 5;378(14):1277-1290. doi: 10.1056/NEJMoa1712126. Epub 2018 Mar 21. N Engl J Med. 2018. PMID: 29562145 Free PMC article. Clinical Trial.
The median progression-free survival was 11.6 months and 8.4 months, respectively (hazard ratio for disease progression or death, 0.82; P=0.03, not significant per the prespecified 0.009 threshold). Treatment-related adverse events occurred in 509 of 547 patients (93%) in …
The median progression-free survival was 11.6 months and 8.4 months, respectively (hazard ratio for disease progression or death, 0.82; P=0. …
BRAF-MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas.
Brastianos PK, Twohy E, Geyer S, Gerstner ER, Kaufmann TJ, Tabrizi S, Kabat B, Thierauf J, Ruff MW, Bota DA, Reardon DA, Cohen AL, De La Fuente MI, Lesser GJ, Campian J, Agarwalla PK, Kumthekar P, Mann B, Vora S, Knopp M, Iafrate AJ, Curry WT Jr, Cahill DP, Shih HA, Brown PD, Santagata S, Barker FG 2nd, Galanis E. Brastianos PK, et al. N Engl J Med. 2023 Jul 13;389(2):118-126. doi: 10.1056/NEJMoa2213329. N Engl J Med. 2023. PMID: 37437144 Free PMC article. Clinical Trial.
The sole patient who did not have a response stopped treatment after 8 days owing to toxic effects. Grade 3 adverse events that were at least possibly related to treatment occurred in 12 patients, including rash in 6 patients. In 2 patients, grade 4 adverse e …
The sole patient who did not have a response stopped treatment after 8 days owing to toxic effects. Grade 3 adverse events tha …
Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma.
Rohaan MW, Borch TH, van den Berg JH, Met Ö, Kessels R, Geukes Foppen MH, Stoltenborg Granhøj J, Nuijen B, Nijenhuis C, Jedema I, van Zon M, Scheij S, Beijnen JH, Hansen M, Voermans C, Noringriis IM, Monberg TJ, Holmstroem RB, Wever LDV, van Dijk M, Grijpink-Ongering LG, Valkenet LHM, Torres Acosta A, Karger M, Borgers JSW, Ten Ham RMT, Retèl VP, van Harten WH, Lalezari F, van Tinteren H, van der Veldt AAM, Hospers GAP, Stevense-den Boer MAM, Suijkerbuijk KPM, Aarts MJB, Piersma D, van den Eertwegh AJM, de Groot JB, Vreugdenhil G, Kapiteijn E, Boers-Sonderen MJ, Fiets WE, van den Berkmortel FWPJ, Ellebaek E, Hölmich LR, van Akkooi ACJ, van Houdt WJ, Wouters MWJM, van Thienen JV, Blank CU, Meerveld-Eggink A, Klobuch S, Wilgenhof S, Schumacher TN, Donia M, Svane IM, Haanen JBAG. Rohaan MW, et al. N Engl J Med. 2022 Dec 8;387(23):2113-2125. doi: 10.1056/NEJMoa2210233. N Engl J Med. 2022. PMID: 36477031 Clinical Trial.
Median overall survival was 25.8 months (95% CI, 18.2 to not reached) in the TIL group and 18.9 months (95% CI, 13.8 to 32.6) in the ipilimumab group. Treatment-related adverse events of grade 3 or higher occurred in all patients who received TILs and in 57% of those who r …
Median overall survival was 25.8 months (95% CI, 18.2 to not reached) in the TIL group and 18.9 months (95% CI, 13.8 to 32.6) in the ipilimu …
Different methods for evaluating the effects of microwave radiation exposure on the nervous system.
Altunkaynak BZ, Altun G, Yahyazadeh A, Kaplan AA, Deniz OG, Türkmen AP, Önger ME, Kaplan S. Altunkaynak BZ, et al. J Chem Neuroanat. 2016 Sep;75(Pt B):62-9. doi: 10.1016/j.jchemneu.2015.11.004. Epub 2015 Dec 12. J Chem Neuroanat. 2016. PMID: 26686295 Review.
Microwave radiation (MWR) leads to hazardous effects on he central nervous system (CNS) for both human and animals. ...The main aim of this paper is to discuss possible side effects of MWR in the light of current literature with different methodologica …
Microwave radiation (MWR) leads to hazardous effects on he central nervous system (CNS) for both human and animals. ...The mai …
Oxidative and mutagenic effects of low intensity GSM 1800 MHz microwave radiation.
Yakymenko I, Burlaka A, Tsybulin I, Brieieva I, Buchynska L, Tsehmistrenko I, Chekhun F. Yakymenko I, et al. Exp Oncol. 2018 Dec;40(4):282-287. Exp Oncol. 2018. PMID: 30593748
AIM: Despite a significant number of epidemiological studies on potential carcinogenicity of microwave radiation (MWR) from wireless devices and a bulk of experimental studies on oxidative and mutagenic effects of low intensity MWR, the discussion on potentia …
AIM: Despite a significant number of epidemiological studies on potential carcinogenicity of microwave radiation (MWR) from wireless …
After-effect induced by microwave radiation in human electroencephalographic signal: a feasibility study.
Bachmann M, Päeske L, Ioannides AA, Lass J, Hinrikus H. Bachmann M, et al. Int J Radiat Biol. 2018 Oct;94(10):896-901. doi: 10.1080/09553002.2018.1478164. Epub 2018 Jun 20. Int J Radiat Biol. 2018. PMID: 29775395
METHODS: To trigger onset and offset effects in EEG, repetitive MWR stimuli were used. Four 30-channel EEG recordings on a single subject were performed, each about one month apart. ...During a recording, 40 cycles of 30 s on-off MWR exposure were used. The a …
METHODS: To trigger onset and offset effects in EEG, repetitive MWR stimuli were used. Four 30-channel EEG recordings on a sin …
Results of the FUEL Trial.
Goldberg DJ, Zak V, Goldstein BH, Schumacher KR, Rhodes J, Penny DJ, Petit CJ, Ginde S, Menon SC, Kim SH, Kim GB, Nowlen TT, DiMaria MV, Frischhertz BP, Wagner JB, McHugh KE, McCrindle BW, Shillingford AJ, Sabati AA, Yetman AT, John AS, Richmond ME, Files MD, Payne RM, Mackie AS, Davis CK, Shahanavaz S, Hill KD, Garg R, Jacobs JP, Hamstra MS, Woyciechowski S, Rathge KA, McBride MG, Frommelt PC, Russell MW, Urbina EM, Yeager JL, Pemberton VL, Stylianou MP, Pearson GD, Paridon SM; Pediatric Heart Network Investigators. Goldberg DJ, et al. Circulation. 2020 Feb 25;141(8):641-651. doi: 10.1161/CIRCULATIONAHA.119.044352. Epub 2019 Nov 17. Circulation. 2020. PMID: 31736357 Free PMC article. Clinical Trial.
Effects of Low-Intensity Microwave Radiation on Oxidant-Antioxidant Parameters and DNA Damage in the Liver of Rats.
Alkis ME, Akdag MZ, Dasdag S. Alkis ME, et al. Bioelectromagnetics. 2021 Jan;42(1):76-85. doi: 10.1002/bem.22315. Epub 2020 Dec 25. Bioelectromagnetics. 2021. PMID: 33368426
The continuously increasing usage of cell phones has raised concerns about the adverse effects of microwave radiation (MWR) emitted by cell phones on health. Several in vitro and in vivo studies have claimed that MWR may cause various kinds of damage i …
The continuously increasing usage of cell phones has raised concerns about the adverse effects of microwave radiation (MWR
The association of intensive blood pressure treatment and non-fatal cardiovascular or serious adverse events in older adults with mortality: mediation analysis in SPRINT.
Krishnaswami A, Rich MW, Kwak MJ, Goyal P, Forman DE, Damluji AA, Solomon M, Rana JS, Kado DM, Odden MC. Krishnaswami A, et al. Eur J Prev Cardiol. 2023 Aug 1;30(10):996-1004. doi: 10.1093/eurjpc/zwad132. Eur J Prev Cardiol. 2023. PMID: 37185634 Free PMC article.
AIMS: Randomized clinical trials of hypertension treatment intensity evaluate the effects on incident major adverse cardiovascular events (MACEs) and serious adverse events (SAEs). ...The harm of intensive BP treatment, increase in ACM, was amplified when med …
AIMS: Randomized clinical trials of hypertension treatment intensity evaluate the effects on incident major adverse cardiovasc …
Pollution characteristics and health risk assessment of potentially toxic elements in soils around China's gold mines: a meta-analysis.
Chen L, Wang J, Guo X, Wu H, He H, Fang L. Chen L, et al. Environ Geochem Health. 2022 Nov;44(11):3765-3777. doi: 10.1007/s10653-021-01175-8. Epub 2022 Jan 17. Environ Geochem Health. 2022. PMID: 35037140 Review.
Since toxic element pollution is widespread in soils near gold mines due to increasing mining activities, the adverse effects of potentially toxic elements (PTEs) in the soils on ecological systems and human health cannot be ignored. ...
Since toxic element pollution is widespread in soils near gold mines due to increasing mining activities, the adverse effects
38 results