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501 results

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Page 1
Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors.
Mavrommatis L, Jeong HW, Kindler U, Gomez-Giro G, Kienitz MC, Stehling M, Psathaki OE, Zeuschner D, Bixel MG, Han D, Morosan-Puopolo G, Gerovska D, Yang JH, Kim JB, Arauzo-Bravo MJ, Schwamborn JC, Hahn SA, Adams RH, Schöler HR, Vorgerd M, Brand-Saberi B, Zaehres H. Mavrommatis L, et al. Elife. 2023 Nov 14;12:RP87081. doi: 10.7554/eLife.87081. Elife. 2023. PMID: 37963071 Free PMC article.
The iPSCs can then be converted into specific cell types in the laboratory, including the cells that make up skeletal muscle. Here, Mavrommatis et al. created a protocol for developing iPSCs into three-dimensional organoids which resemble how cells of the skeleta …
The iPSCs can then be converted into specific cell types in the laboratory, including the cells that make up skeletal muscle. …
TMEM182 interacts with integrin beta 1 and regulates myoblast differentiation and muscle regeneration.
Luo W, Lin Z, Chen J, Chen G, Zhang S, Liu M, Li H, He D, Liang S, Luo Q, Zhang D, Nie Q, Zhang X. Luo W, et al. J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1704-1723. doi: 10.1002/jcsm.12767. Epub 2021 Aug 23. J Cachexia Sarcopenia Muscle. 2021. PMID: 34427057 Free PMC article.
RESULTS: TMEM182 was specifically expressed in skeletal muscle and adipose tissue and was regulated at the transcriptional level by the myogenic regulatory factor MyoD1. ...TMEM182 knockout in mice led to significant increases in body weight, muscle ma …
RESULTS: TMEM182 was specifically expressed in skeletal muscle and adipose tissue and was regulated at the transcriptional lev …
Pim1 kinase positively regulates myoblast behaviors and skeletal muscle regeneration.
Liu Y, Shang Y, Yan Z, Li H, Wang Z, Liu Z, Li Z. Liu Y, et al. Cell Death Dis. 2019 Oct 10;10(10):773. doi: 10.1038/s41419-019-1993-3. Cell Death Dis. 2019. PMID: 31601787 Free PMC article.
Adult skeletal muscle regeneration after injury depends on normal myoblast function. However, the intrinsic mechanisms for the control of myoblast behaviors are not well defined. ...Taken together, our study provides a potential target for the manipula …
Adult skeletal muscle regeneration after injury depends on normal myoblast function. However, the intrinsic mechanisms …
Engineered matrices for skeletal muscle satellite cell engraftment and function.
Han WM, Jang YC, García AJ. Han WM, et al. Matrix Biol. 2017 Jul;60-61:96-109. doi: 10.1016/j.matbio.2016.06.001. Epub 2016 Jun 4. Matrix Biol. 2017. PMID: 27269735 Free PMC article. Review.
Regeneration of traumatically injured skeletal muscles is severely limited. Moreover, the regenerative capacity of skeletal muscle declines with aging, further exacerbating the problem. ...However, direct delivery of satellite cells presents a challenge at a …
Regeneration of traumatically injured skeletal muscles is severely limited. Moreover, the regenerative capacity of skeletal …
Cardiolipin metabolism regulates expression of muscle transcription factor MyoD1 and muscle development.
Vo L, Schmidtke MW, Da Rosa-Junior NT, Ren M, Schlame M, Greenberg ML. Vo L, et al. J Biol Chem. 2023 Mar;299(3):102978. doi: 10.1016/j.jbc.2023.102978. Epub 2023 Feb 4. J Biol Chem. 2023. PMID: 36739949 Free PMC article.
Interestingly, the muscle transcription factor myoblast determination protein 1 (MyoD1) is significantly repressed in TAZ-KO cells and TAZ-KO mouse hearts. ...Our findings reveal, for the first time, that CL metabolism regulates muscle differentiation …
Interestingly, the muscle transcription factor myoblast determination protein 1 (MyoD1) is significantly repressed in T …
Keratocan Improves Muscle Wasting in Sarcopenia by Promoting Skeletal Muscle Development and Fast-Twitch Fibre Synthesis.
Chen X, Zhang Y, Deng Z, Song C, Yang L, Zhang R, Zhang P, Xiu Y, Su Y, Luo J, Xu J, Dai H. Chen X, et al. J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13724. doi: 10.1002/jcsm.13724. J Cachexia Sarcopenia Muscle. 2025. PMID: 39962589 Free PMC article.
This study aimed to elucidate the role and molecular mechanisms of keratocan in skeletal muscle. METHODS: We analysed keratocan expression in the muscles of aged mice and patients with osteosarcopenia and during the differentiation of C2C12 myoblasts. ...CONC …
This study aimed to elucidate the role and molecular mechanisms of keratocan in skeletal muscle. METHODS: We analysed keratoca …
Foxo3 Knockdown Mediates Decline of Myod1 and Myog Reducing Myoblast Conversion to Myotubes.
Gellhaus B, Böker KO, Gsaenger M, Rodenwaldt E, Hüser MA, Schilling AF, Saul D. Gellhaus B, et al. Cells. 2023 Aug 29;12(17):2167. doi: 10.3390/cells12172167. Cells. 2023. PMID: 37681900 Free PMC article.
Successfully transduced myoblasts were selected via FACS cell sorting to establish single clone cell lines. Sorted myoblasts were further differentiated into myotubes and stained for myosin heavy chain (MHC) by immunofluorescence. ...We found an increased Foxo3 expr …
Successfully transduced myoblasts were selected via FACS cell sorting to establish single clone cell lines. Sorted myoblasts w …
Role and mechanism of catechin in skeletal muscle cell differentiation.
Li P, Liu A, Liu C, Qu Z, Xiao W, Huang J, Liu Z, Zhang S. Li P, et al. J Nutr Biochem. 2019 Dec;74:108225. doi: 10.1016/j.jnutbio.2019.108225. Epub 2019 Aug 15. J Nutr Biochem. 2019. PMID: 31629963
Catechins in tea enhance skeletal muscle performance, but the specific function and mechanism require further exploration. ...The results provide a powerful basis for further study of catechin-enhanced skeletal muscle regeneration and repair....
Catechins in tea enhance skeletal muscle performance, but the specific function and mechanism require further exploration. ... …
SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development.
Sha R, Guo R, Duan H, Peng Q, Yuan N, Wang Z, Li Z, Xie Z, You X, Feng Y. Sha R, et al. Elife. 2024 Sep 9;13:RP98175. doi: 10.7554/eLife.98175. Elife. 2024. PMID: 39248331 Free PMC article.
The absence of Srsf2 in MyoD + progenitors resulted in perinatal mortality in mice, accompanied by severe skeletal muscle defects. SRSF2 deficiency disrupts the directional migration of MyoD progenitors, causing them to disperse into both muscle and non-mu …
The absence of Srsf2 in MyoD + progenitors resulted in perinatal mortality in mice, accompanied by severe skeletal muscle defe …
Moderate hypoxia promotes skeletal muscle cell growth and hypertrophy in C2C12 cells.
Sakushima K, Yoshikawa M, Osaki T, Miyamoto N, Hashimoto T. Sakushima K, et al. Biochem Biophys Res Commun. 2020 May 14;525(4):921-927. doi: 10.1016/j.bbrc.2020.02.152. Epub 2020 Mar 12. Biochem Biophys Res Commun. 2020. PMID: 32173524 Free article.
The purpose of the present study was to examine the effect of semisevere (i.e., 5%) to moderate (i.e., 10% or 15%) hypoxic environments on the morphological characteristics of skeletal muscle and the associated mechanisms. C2C12 skeletal muscle cells w …
The purpose of the present study was to examine the effect of semisevere (i.e., 5%) to moderate (i.e., 10% or 15%) hypoxic environments on t …
501 results