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A Broad-Spectrum Inhibitor of CRISPR-Cas9.
Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. Harrington LB, et al. Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24. Cell. 2017. PMID: 28844692 Free PMC article.
CasX enzymes comprise a distinct family of RNA-guided genome editors.
Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knott GJ, Harrington LB, Al-Shayeb B, Wagner A, Brötzmann J, Staahl BT, Taylor KL, Desmarais J, Nogales E, Doudna JA. Liu JJ, et al. Nature. 2019 Feb;566(7743):218-223. doi: 10.1038/s41586-019-0908-x. Epub 2019 Feb 4. Nature. 2019. PMID: 30718774 Free PMC article.
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes.
Harrington LB, Burstein D, Chen JS, Paez-Espino D, Ma E, Witte IP, Cofsky JC, Kyrpides NC, Banfield JF, Doudna JA. Harrington LB, et al. Science. 2018 Nov 16;362(6416):839-842. doi: 10.1126/science.aav4294. Epub 2018 Oct 18. Science. 2018. PMID: 30337455 Free PMC article.
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA. Jinek M, et al. Science. 2014 Mar 14;343(6176):1247997. doi: 10.1126/science.1247997. Epub 2014 Feb 6. Science. 2014. PMID: 24505130 Free PMC article.
RNA-programmed genome editing in human cells.
Jinek M, East A, Cheng A, Lin S, Ma E, Doudna J. Jinek M, et al. Elife. 2013 Jan 29;2:e00471. doi: 10.7554/eLife.00471. Elife. 2013. PMID: 23386978 Free PMC article.
Autoinhibition of human dicer by its internal helicase domain.
Ma E, MacRae IJ, Kirsch JF, Doudna JA. Ma E, et al. J Mol Biol. 2008 Jun 27;380(1):237-43. doi: 10.1016/j.jmb.2008.05.005. Epub 2008 May 8. J Mol Biol. 2008. PMID: 18508075 Free PMC article.
Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes.
Ma E, Harrington LB, O'Connell MR, Zhou K, Doudna JA. Ma E, et al. Mol Cell. 2015 Nov 5;60(3):398-407. doi: 10.1016/j.molcel.2015.10.030. Mol Cell. 2015. PMID: 26545076 Free PMC article.
A thermostable Cas9 with increased lifetime in human plasma.
Harrington LB, Paez-Espino D, Staahl BT, Chen JS, Ma E, Kyrpides NC, Doudna JA. Harrington LB, et al. Nat Commun. 2017 Nov 10;8(1):1424. doi: 10.1038/s41467-017-01408-4. Nat Commun. 2017. PMID: 29127284 Free PMC article.
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