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Learning regulatory programs by threshold SVD regression.
Ma X, Xiao L, Wong WH. Ma X, et al. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15675-80. doi: 10.1073/pnas.1417808111. Epub 2014 Oct 20. Proc Natl Acad Sci U S A. 2014. PMID: 25331876 Free PMC article.
We formulate a statistical model for the regulation of global gene expression by multiple regulatory programs and propose a thresholding singular value decomposition (T-SVD) regression method for learning such a model from data. ...
We formulate a statistical model for the regulation of global gene expression by multiple regulatory programs and propose a th …
Crystal structure of the GTP-binding protein-like domain of AGAP1.
Cheng N, Zhang H, Zhang S, Ma X, Meng G. Cheng N, et al. Among authors: ma x. Acta Crystallogr F Struct Biol Commun. 2021 Apr 1;77(Pt 4):105-112. doi: 10.1107/S2053230X21003150. Epub 2021 Mar 31. Acta Crystallogr F Struct Biol Commun. 2021. PMID: 33830075
Additionally, this study indicates that AGAP1 could be classified as a type of NTPase, the activity of which might be regulated by protein partners or by its other domains. Taken together, these results provide insight into the regulatory mechanisms of AGAP1 in cell signal …
Additionally, this study indicates that AGAP1 could be classified as a type of NTPase, the activity of which might be regulated by protein p …
Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function.
Xu X, Ding G, Liu C, Ding Y, Chen X, Huang X, Zhang CS, Lu S, Zhang Y, Huang Y, Chen Z, Wei W, Liao L, Lin SH, Li J, Liu W, Li J, Lin SC, Ma X, Wong J. Xu X, et al. Among authors: ma x. Cell Res. 2021 Sep 24. doi: 10.1038/s41422-021-00565-y. Online ahead of print. Cell Res. 2021. PMID: 34561619
The AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis. Although much has been learned on how low energy status and glucose starvation activate AMPK, how AMPK activity is properly controlled in vivo is still poorly understood. ...
The AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis. Although much has been learned on how low energ …