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Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.
Tanenbaum ME, Macůrek L, Galjart N, Medema RH. Tanenbaum ME, et al. Among authors: macurek l. EMBO J. 2008 Dec 17;27(24):3235-45. doi: 10.1038/emboj.2008.242. Epub 2008 Nov 20. EMBO J. 2008. PMID: 19020519 Free PMC article.
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH. Macůrek L, et al. Nature. 2008 Sep 4;455(7209):119-23. doi: 10.1038/nature07185. Epub 2008 Jul 9. Nature. 2008. PMID: 18615013
Aurora-A and hBora join the game of Polo.
Macurek L, Lindqvist A, Medema RH. Macurek L, et al. Cancer Res. 2009 Jun 1;69(11):4555-8. doi: 10.1158/0008-5472.CAN-09-0142. Cancer Res. 2009. PMID: 19487276 Review.
Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.
Lindqvist A, de Bruijn M, Macurek L, Brás A, Mensinga A, Bruinsma W, Voets O, Kranenburg O, Medema RH. Lindqvist A, et al. Among authors: macurek l. EMBO J. 2009 Oct 21;28(20):3196-206. doi: 10.1038/emboj.2009.246. Epub 2009 Aug 27. EMBO J. 2009. PMID: 19713933 Free PMC article.
Kif15 cooperates with eg5 to promote bipolar spindle assembly.
Tanenbaum ME, Macůrek L, Janssen A, Geers EF, Alvarez-Fernández M, Medema RH. Tanenbaum ME, et al. Among authors: macurek l. Curr Biol. 2009 Nov 3;19(20):1703-11. doi: 10.1016/j.cub.2009.08.027. Epub 2009 Oct 8. Curr Biol. 2009. PMID: 19818618
A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases.
Tanenbaum ME, Macurek L, van der Vaart B, Galli M, Akhmanova A, Medema RH. Tanenbaum ME, et al. Among authors: macurek l. Curr Biol. 2011 Aug 23;21(16):1356-65. doi: 10.1016/j.cub.2011.07.017. Epub 2011 Aug 4. Curr Biol. 2011. PMID: 21820309
Spatial Separation of Plk1 Phosphorylation and Activity.
Bruinsma W, Aprelia M, Kool J, Macurek L, Lindqvist A, Medema RH. Bruinsma W, et al. Among authors: macurek l. Front Oncol. 2015 Jun 10;5:132. doi: 10.3389/fonc.2015.00132. eCollection 2015. Front Oncol. 2015. PMID: 26114094 Free PMC article.
ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
Jaiswal H, Benada J, Müllers E, Akopyan K, Burdova K, Koolmeister T, Helleday T, Medema RH, Macurek L, Lindqvist A. Jaiswal H, et al. Among authors: macurek l. EMBO J. 2017 Jul 14;36(14):2161-2176. doi: 10.15252/embj.201696082. Epub 2017 Jun 12. EMBO J. 2017. PMID: 28607002 Free PMC article.
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
Macůrek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH. Macůrek L, et al. Oncogene. 2010 Apr 15;29(15):2281-91. doi: 10.1038/onc.2009.501. Epub 2010 Jan 25. Oncogene. 2010. PMID: 20101220
Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase.
Macurek L, Dráberová E, Richterová V, Sulimenko V, Sulimenko T, Dráberová L, Marková V, Dráber P. Macurek L, et al. Biochem J. 2008 Dec 15;416(3):421-30. doi: 10.1042/BJ20080909. Biochem J. 2008. PMID: 18636972
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