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A pharmacodynamic model of Aurora kinase inhibitors in the spindle assembly checkpoint.
Mistry HB, MacCallum DE, Jackson RC, Chaplain MA, Davidson FA. Mistry HB, et al. Among authors: maccallum de. Front Biosci (Landmark Ed). 2010 Jan 1;15:249-58. doi: 10.2741/3619. Front Biosci (Landmark Ed). 2010. PMID: 20036819
Modeling the temporal evolution of the spindle assembly checkpoint and role of Aurora B kinase.
Mistry HB, MacCallum DE, Jackson RC, Chaplain MA, Davidson FA. Mistry HB, et al. Among authors: maccallum de. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20215-20. doi: 10.1073/pnas.0810706106. Epub 2008 Dec 17. Proc Natl Acad Sci U S A. 2008. PMID: 19091947 Free PMC article.
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.
MacCallum DE, Melville J, Frame S, Watt K, Anderson S, Gianella-Borradori A, Lane DP, Green SR. MacCallum DE, et al. Cancer Res. 2005 Jun 15;65(12):5399-407. doi: 10.1158/0008-5472.CAN-05-0233. Cancer Res. 2005. PMID: 15958589 Free article.
The location of pKi67 in the outer dense fibrillary compartment of the nucleolus points to a role in ribosome biogenesis during the cell division cycle.
MacCallum DE, Hall PA. MacCallum DE, et al. J Pathol. 2000 Apr;190(5):537-44. doi: 10.1002/(SICI)1096-9896(200004)190:5<537::AID-PATH577>3.0.CO;2-W. J Pathol. 2000. PMID: 10727979
The Trp53 pathway is induced in vivo by low doses of gamma radiation.
MacCallum DE, Hall PA, Wright EG. MacCallum DE, et al. Radiat Res. 2001 Sep;156(3):324-7. doi: 10.1667/0033-7587(2001)156[0324:ttpiii];2. Radiat Res. 2001. PMID: 11500142
The biochemical characterization of the DNA binding activity of pKi67.
MacCallum DE, Hall PA. MacCallum DE, et al. J Pathol. 2000 Jul;191(3):286-98. doi: 10.1002/1096-9896(2000)9999:9999<::AID-PATH628>3.0.CO;2-J. J Pathol. 2000. PMID: 10878551
A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.
Alvi AJ, Austen B, Weston VJ, Fegan C, MacCallum D, Gianella-Borradori A, Lane DP, Hubank M, Powell JE, Wei W, Taylor AM, Moss PA, Stankovic T. Alvi AJ, et al. Blood. 2005 Jun 1;105(11):4484-91. doi: 10.1182/blood-2004-07-2713. Epub 2005 Feb 3. Blood. 2005. PMID: 15692065
Expression of the 'dead box' RNA helicase p68 is developmentally and growth regulated and correlates with organ differentiation/maturation in the fetus.
Stevenson RJ, Hamilton SJ, MacCallum DE, Hall PA, Fuller-Pace FV. Stevenson RJ, et al. J Pathol. 1998 Apr;184(4):351-9. doi: 10.1002/(SICI)1096-9896(199804)184:4<351::AID-PATH1235>3.0.CO;2-C. J Pathol. 1998. PMID: 9664900
Induction of p53 protein as a marker for ionizing radiation exposure in vivo.
MacCallum DE, Hupp TR. MacCallum DE, et al. Methods Mol Biol. 1999;113:583-9. doi: 10.1385/1-59259-675-4:583. Methods Mol Biol. 1999. PMID: 10443453 No abstract available.
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