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Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.
Macdonald D, Mastracchio A, Perrier H, Dubé D, Gallant M, Lacombe P, Deschênes D, Roy B, Scheigetz J, Bateman K, Li C, Trimble LA, Day S, Chauret N, Nicoll-Griffith DA, Silva JM, Huang Z, Laliberté F, Liu S, Ethier D, Pon D, Muise E, Boulet L, Chan CC, Styhler A, Charleson S, Mancini J, Masson P, Claveau D, Nicholson D, Turner M, Young RN, Girard Y. Macdonald D, et al. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5241-6. doi: 10.1016/j.bmcl.2005.08.036. Epub 2005 Sep 15. Bioorg Med Chem Lett. 2005. PMID: 16168647
Substituted furans as inhibitors of the PDE4 enzyme.
Perrier H, Bayly C, Laliberté F, Huang Z, Rasori R, Robichaud A, Girard Y, Macdonald D. Perrier H, et al. Among authors: macdonald d. Bioorg Med Chem Lett. 1999 Feb 8;9(3):323-6. doi: 10.1016/s0960-894x(98)00742-2. Bioorg Med Chem Lett. 1999. PMID: 10091677
The next generation of PDE4 inhibitors.
Huang Z, Ducharme Y, Macdonald D, Robichaud A. Huang Z, et al. Among authors: macdonald d. Curr Opin Chem Biol. 2001 Aug;5(4):432-8. doi: 10.1016/s1367-5931(00)00224-6. Curr Opin Chem Biol. 2001. PMID: 11470607 Review.
Neuroanatomical and pharmacological assessment of Fos expression induced in the rat brain by the phosphodiesterase-4 inhibitor 6-(4-pyridylmethyl)-8-(3-nitrophenyl) quinoline.
Bureau Y, Handa M, Zhu Y, Laliberte F, Moore CS, Liu S, Huang Z, MacDonald D, Xu DG, Robertson GS. Bureau Y, et al. Among authors: macdonald d. Neuropharmacology. 2006 Oct;51(5):974-85. doi: 10.1016/j.neuropharm.2006.06.018. Epub 2006 Aug 9. Neuropharmacology. 2006. PMID: 16901513
Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors.
Lacombe P, Deschênes D, Dubé D, Dubé L, Gallant M, Macdonald D, Mastracchio A, Perrier H, Charleson S, Huang Z, Laliberté F, Liu S, Mancini JA, Masson P, Salem M, Styhler A, Girard Y. Lacombe P, et al. Among authors: macdonald d. Bioorg Med Chem Lett. 2006 May 15;16(10):2608-12. doi: 10.1016/j.bmcl.2006.02.043. Epub 2006 Mar 3. Bioorg Med Chem Lett. 2006. PMID: 16516471
Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors.
Gallant M, Chauret N, Claveau D, Day S, Deschênes D, Dubé D, Huang Z, Lacombe P, Laliberté F, Lévesque JF, Liu S, Macdonald D, Mancini J, Masson P, Mastracchio A, Nicholson D, Nicoll-Griffith DA, Perrier H, Salem M, Styhler A, Young RN, Girard Y. Gallant M, et al. Among authors: macdonald d. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1407-12. doi: 10.1016/j.bmcl.2008.01.004. Epub 2008 Jan 8. Bioorg Med Chem Lett. 2008. PMID: 18207397
Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.
Lacombe P, Chauret N, Claveau D, Day S, Deschênes D, Dubé D, Gallant M, Girard Y, Huang Z, Laliberté F, Lévesque JF, Liu S, Macdonald D, Mancini JA, Masson P, Nicholson DW, Nicoll-Griffith DA, Salem M, Styhler A, Young RN. Lacombe P, et al. Among authors: macdonald d. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5266-9. doi: 10.1016/j.bmcl.2009.03.105. Epub 2009 Mar 26. Bioorg Med Chem Lett. 2009. PMID: 19640717
L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition.
Huang Z, Dias R, Jones T, Liu S, Styhler A, Claveau D, Otu F, Ng K, Laliberte F, Zhang L, Goetghebeur P, Abraham WM, Macdonald D, Dubé D, Gallant M, Lacombe P, Girard Y, Young RN, Turner MJ, Nicholson DW, Mancini JA. Huang Z, et al. Among authors: macdonald d. Biochem Pharmacol. 2007 Jun 15;73(12):1971-81. doi: 10.1016/j.bcp.2007.03.010. Epub 2007 Mar 16. Biochem Pharmacol. 2007. PMID: 17428447
2,358 results