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Influence of glucose on pyruvate carboxylase expression in pancreatic islets.
MacDonald MJ. MacDonald MJ. Arch Biochem Biophys. 1995 May 10;319(1):128-32. doi: 10.1006/abbi.1995.1274. Arch Biochem Biophys. 1995. PMID: 7771776
Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion.
Ansari IH, Longacre MJ, Stoker SW, Kendrick MA, O'Neill LM, Zitur LJ, Fernandez LA, Ntambi JM, MacDonald MJ. Ansari IH, et al. Among authors: macdonald mj. Arch Biochem Biophys. 2017 Mar 15;618:32-43. doi: 10.1016/j.abb.2017.02.001. Epub 2017 Feb 11. Arch Biochem Biophys. 2017. PMID: 28193492 Free PMC article.
Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.
Phannasil P, Ansari IH, El Azzouny M, Longacre MJ, Rattanapornsompong K, Burant CF, MacDonald MJ, Jitrapakdee S. Phannasil P, et al. Among authors: macdonald mj. Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):537-551. doi: 10.1016/j.bbadis.2016.11.021. Epub 2016 Nov 24. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 27890529 Free PMC article.
Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion.
El Azzouny M, Longacre MJ, Ansari IH, Kennedy RT, Burant CF, MacDonald MJ. El Azzouny M, et al. Among authors: macdonald mj. Mol Metab. 2016 Aug 8;5(10):980-987. doi: 10.1016/j.molmet.2016.07.011. eCollection 2016 Oct. Mol Metab. 2016. PMID: 27689010 Free PMC article.
Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells.
Phannasil P, Thuwajit C, Warnnissorn M, Wallace JC, MacDonald MJ, Jitrapakdee S. Phannasil P, et al. Among authors: macdonald mj. PLoS One. 2015 Jun 12;10(6):e0129848. doi: 10.1371/journal.pone.0129848. eCollection 2015. PLoS One. 2015. PMID: 26070193 Free PMC article.
Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element.
Wutthisathapornchai A, Vongpipatana T, Muangsawat S, Boonsaen T, MacDonald MJ, Jitrapakdee S. Wutthisathapornchai A, et al. Among authors: macdonald mj. PLoS One. 2014 Jul 23;9(7):e102730. doi: 10.1371/journal.pone.0102730. eCollection 2014. PLoS One. 2014. PMID: 25054881 Free PMC article.
Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells.
MacDonald MJ, Hasan NM, Dobrzyn A, Stoker SW, Ntambi JM, Liu X, Sampath H. MacDonald MJ, et al. Arch Biochem Biophys. 2013 Apr 1;532(1):23-31. doi: 10.1016/j.abb.2013.01.002. Epub 2013 Jan 25. Arch Biochem Biophys. 2013. PMID: 23357280 Free PMC article.
Characterization of the distal promoter of the human pyruvate carboxylase gene in pancreatic beta cells.
Thonpho A, Rojvirat P, Jitrapakdee S, MacDonald MJ. Thonpho A, et al. Among authors: macdonald mj. PLoS One. 2013;8(1):e55139. doi: 10.1371/journal.pone.0055139. Epub 2013 Jan 30. PLoS One. 2013. PMID: 23383084 Free PMC article.
Anaplerosis from glucose, alpha-ketoisocaproate, and pyruvate in pancreatic islets, INS-1 cells and liver mitochondria.
MacDonald MJ, Stoker SW, Hasan NM. MacDonald MJ, et al. Mol Cell Biochem. 2008 Jun;313(1-2):195-202. doi: 10.1007/s11010-008-9757-x. Epub 2008 Apr 15. Mol Cell Biochem. 2008. PMID: 18414997
Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion.
MacDonald MJ, Fahien LA, Brown LJ, Hasan NM, Buss JD, Kendrick MA. MacDonald MJ, et al. Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E1-15. doi: 10.1152/ajpendo.00218.2004. Am J Physiol Endocrinol Metab. 2005. PMID: 15585595 Review.
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