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Pore dilation of neuronal P2X receptor channels.
Virginio C, MacKenzie A, Rassendren FA, North RA, Surprenant A. Virginio C, et al. Nat Neurosci. 1999 Apr;2(4):315-21. doi: 10.1038/7225. Nat Neurosci. 1999. PMID: 10204537
Brief (< 1 s) applications of ATP to nodose ganglion neurons or to cells transfected with P2X2 or P2X4 receptor cDNAs induce the opening of a channel selectively permeable to small cations within milliseconds. ...Progressive dilation of the ion-conducting pathway during …
Brief (< 1 s) applications of ATP to nodose ganglion neurons or to cells transfected with P2X2 or P2X4 receptor cDNAs induce the opening …
N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X(7) receptors.
Jiang LH, Rassendren F, Mackenzie A, Zhang YH, Surprenant A, North RA. Jiang LH, et al. Am J Physiol Cell Physiol. 2005 Nov;289(5):C1295-302. doi: 10.1152/ajpcell.00253.2005. Epub 2005 Aug 10. Am J Physiol Cell Physiol. 2005. PMID: 16093280
The similarity in the time course of these two events has led to the widespread view that N-methyl-d-glucamine and YO-PRO-1 enter through a common permeation pathway, the "dilating" P2X(7) receptor pore. ...Second, we deleted a cysteine-rich 18-amino acid segment in …
The similarity in the time course of these two events has led to the widespread view that N-methyl-d-glucamine and YO-PRO-1 enter through …
Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X7 receptor.
Virginio C, MacKenzie A, North RA, Surprenant A. Virginio C, et al. J Physiol. 1999 Sep 1;519 Pt 2(Pt 2):335-46. doi: 10.1111/j.1469-7793.1999.0335m.x. J Physiol. 1999. PMID: 10457053 Free PMC article.
Electrophysiological measurements of current reversal potentials with intracellular sodium and extracellular cations of different sizes showed that the ionic channel progressively t'2+LE0i%-i"dilated during 10-20 s to a diameter greater than 1 nm (10 A). ...We concl …
Electrophysiological measurements of current reversal potentials with intracellular sodium and extracellular cations of different sizes show …
Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors.
Jiang LH, Mackenzie AB, North RA, Surprenant A. Jiang LH, et al. Mol Pharmacol. 2000 Jul;58(1):82-8. Mol Pharmacol. 2000. PMID: 10860929
Brilliant Blue G produced a noncompetitive inhibition of rat and human P2X(7) receptors with IC(50) values of 10 and 200 nM, respectively. ...
Brilliant Blue G produced a noncompetitive inhibition of rat and human P2X(7) receptors with IC(50) values of 10 and 200 nM, respecti …
Activation of receptor-operated cation channels via P2X1 not P2T purinoceptors in human platelets.
MacKenzie AB, Mahaut-Smith MP, Sage SO. MacKenzie AB, et al. J Biol Chem. 1996 Feb 9;271(6):2879-81. doi: 10.1074/jbc.271.6.2879. J Biol Chem. 1996. PMID: 8621673
In "nystatin" whole-cell patch clamp recordings, ATP, ADP, and the non-hydrolyzable ATP analogues, alpha, beta-meATP and ATPgammaS (adenosine 5 -O-(3-thiotriphosphate), all activated a cation channel permeable to both monovalent and divalent cations with a single-ch …
In "nystatin" whole-cell patch clamp recordings, ATP, ADP, and the non-hydrolyzable ATP analogues, alpha, beta-meATP and ATPgammaS (adenosin …
Functional and molecular diversity of purinergic ion channel receptors.
MacKenzie AB, Surprenant A, North RA. MacKenzie AB, et al. Ann N Y Acad Sci. 1999 Apr 30;868:716-29. doi: 10.1111/j.1749-6632.1999.tb11351.x. Ann N Y Acad Sci. 1999. PMID: 10414359 Review.
P2X receptors are membrane ion channels gated by extracellular adenosine 5'-triphosphate (ATP); nucleotides also activate a family of seven transmembrane G protein-coupled receptors (P2Y). ...A third-group type of receptor (termed P2Z) is distinguished by the fact t …
P2X receptors are membrane ion channels gated by extracellular adenosine 5'-triphosphate (ATP); nucleotides also activate a family of …
Purinoceptor-evoked calcium signalling in human platelets.
Sage SO, MacKenzie AB, Jenner S, Mahaut-Smith MP. Sage SO, et al. Prostaglandins Leukot Essent Fatty Acids. 1997 Oct;57(4-5):435-8. doi: 10.1016/s0952-3278(97)90424-5. Prostaglandins Leukot Essent Fatty Acids. 1997. PMID: 9430392 Review.
Store depletion in turn leads to activation of a store-regulated Ca2+ entry pathway via a mechanism which appears to involve a protein tyrosine phosphorylation step. Preceding these events, ADP activates a receptor-operated non-selective cation channel …
Store depletion in turn leads to activation of a store-regulated Ca2+ entry pathway via a mechanism which appears to involve …
Chloride channels in excised membrane patches from human platelets: effect of intracellular calcium.
MacKenzie AB, Mahaut-Smith MP. MacKenzie AB, et al. Biochim Biophys Acta. 1996 Jan 12;1278(1):131-6. doi: 10.1016/0005-2736(95)00207-3. Biochim Biophys Acta. 1996. PMID: 8611601
The single channel conductance was 53 +A- 1 pS at + 80 mV (outward current), decreasing to 20 +/- 2 pS at -80 mV (inward current). ...Furthermore, 5-nitro-2-(3-phenylpropylamino)benzoate (100 microM), a recognized inhibitor of anion channels, induced a revers …
The single channel conductance was 53 +A- 1 pS at + 80 mV (outward current), decreasing to 20 +/- 2 pS at -80 mV (inward current). .. …
The Canadian Neuromuscular Disease Registry 2010-2019: A Decade of Facilitating Clinical Research Through a Nationwide, Pan-Neuromuscular Disease Registry.
Hodgkinson V, Lounsberry J, M'Dahoma S, Russell A, Benstead T, Brais B, Campbell C, Johnston W, Lochmüller H, McCormick A, Nguyen CT, O'Ferrall E, Oskoui M, Briemberg H, Bourque P, Botez S, Cashman N, Chapman K, Chrestian N, Crone M, Dobrowolski P, Dojeiji S, Dowling JJ, Dupré N, Genge A, Gonorazky H, Grant I, Hasal S, Izenberg A, Kalra S, Katzberg H, Krieger C, Leung E, Linassi G, Mackenzie A, Mah JK, Marrero A, Massie R, Matte G, McAdam L, McMillan H, Melanson M, Mezei MM, O'Connell C, Pfeffer G, Phan C, Plamondon S, Poulin C, Rodrigue X, Schellenberg K, Selby K, Sheriko J, Shoesmith C, Smith G, Taillon M, Taylor S, Venance S, Warman-Chardon J, Worley S, Zinman L, Korngut L. Hodgkinson V, et al. Among authors: mackenzie a. J Neuromuscul Dis. 2020 Aug 31. doi: 10.3233/JND-200538. Online ahead of print. J Neuromuscul Dis. 2020. PMID: 32925088
Rigid platform for applying large tunable strains to mechanically delicate samples.
Park J, Bartlett JM, Noad HML, Stern AL, Barber ME, König M, Hosoi S, Shibauchi T, Mackenzie AP, Steppke A, Hicks CW. Park J, et al. Among authors: mackenzie ap. Rev Sci Instrum. 2020 Aug 1;91(8):083902. doi: 10.1063/5.0008829. Rev Sci Instrum. 2020. PMID: 32872945
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