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Studies on the polyglutamate specificity of methylenetetrahydrofolate dehydrogenase from pig liver.
Ross J, Green J, Baugh CM, MacKenzie RE, Matthews RG. Ross J, et al. Biochemistry. 1984 Apr 10;23(8):1796-801. doi: 10.1021/bi00303a033. Biochemistry. 1984. PMID: 6609718
., & MacKenzie, R. E. (1978) Biochim. Biophys. Acta 522, 311-317]. We have studied the inhibition of this activity by a series of pteroylglutamates containing one to seven glutamyl residues. ...
., & MacKenzie, R. E. (1978) Biochim. Biophys. Acta 522, 311-317]. We have studied the inhibition of this activity by a series of …
5,10-methenyltetrahydrofolate cyclohydrolase, rat liver and chemically catalysed formation of 5-formyltetrahydrofolate.
Baggott JE, MacKenzie RE. Baggott JE, et al. Biochem J. 2003 Sep 15;374(Pt 3):773-8. doi: 10.1042/BJ20021970. Biochem J. 2003. PMID: 12793858 Free PMC article.
Using a spectrophotometric assay for 5-HCO-H4folate, human recombinant 5,10-CH=H4folate cyclohydrolase, which catalyses the hydrolysis of 5,10-CH=H4folate to 10-HCO-H4folate, was previously shown to catalyse inefficiently the formation of 5-HCO-H4folate at pH 7.3 [Pelletier and …
Using a spectrophotometric assay for 5-HCO-H4folate, human recombinant 5,10-CH=H4folate cyclohydrolase, which catalyses the hydrolysis of 5, …
The expression of mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase supports a role in rapid cell growth.
Di Pietro E, Wang XL, MacKenzie RE. Di Pietro E, et al. Among authors: mackenzie re. Biochim Biophys Acta. 2004 Sep 6;1674(1):78-84. doi: 10.1016/j.bbagen.2004.06.014. Biochim Biophys Acta. 2004. PMID: 15342116
The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects.
Christensen KE, Rohlicek CV, Andelfinger GU, Michaud J, Bigras JL, Richter A, Mackenzie RE, Rozen R. Christensen KE, et al. Among authors: mackenzie re. Hum Mutat. 2009 Feb;30(2):212-20. doi: 10.1002/humu.20830. Hum Mutat. 2009. PMID: 18767138
NAD- and NADP-dependent mitochondrially targeted methylenetetrahydrofolate dehydrogenase-cyclohydrolases can rescue mthfd2 null fibroblasts.
Patel H, Di Pietro E, Mejia N, MacKenzie RE. Patel H, et al. Among authors: mackenzie re. Arch Biochem Biophys. 2005 Oct 1;442(1):133-9. doi: 10.1016/j.abb.2005.07.022. Arch Biochem Biophys. 2005. PMID: 16150419
Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.
Christensen KE, Mirza IA, Berghuis AM, Mackenzie RE. Christensen KE, et al. Among authors: mackenzie re. J Biol Chem. 2005 Oct 7;280(40):34316-23. doi: 10.1074/jbc.M505210200. Epub 2005 Aug 11. J Biol Chem. 2005. PMID: 16100107 Free article.
Disruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria.
Christensen KE, Patel H, Kuzmanov U, Mejia NR, MacKenzie RE. Christensen KE, et al. Among authors: mackenzie re. J Biol Chem. 2005 Mar 4;280(9):7597-602. doi: 10.1074/jbc.M409380200. Epub 2004 Dec 16. J Biol Chem. 2005. PMID: 15611115 Free article.
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