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OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models.
Berenguer-Daizé C, Astorgues-Xerri L, Odore E, Cayol M, Cvitkovic E, Noel K, Bekradda M, MacKenzie S, Rezai K, Lokiec F, Riveiro ME, Ouafik L. Berenguer-Daizé C, et al. Int J Cancer. 2016 Nov 1;139(9):2047-55. doi: 10.1002/ijc.30256. Epub 2016 Jul 30. Int J Cancer. 2016. PMID: 27388964
Insights into the cellular pharmacological properties of the BET-inhibitor OTX015/MK-8628 (birabresib), alone and in combination, in leukemia models.
Astorgues-Xerri L, Vázquez R, Odore E, Rezai K, Kahatt C, Mackenzie S, Bekradda M, Coudé MM, Dombret H, Gardin C, Lokiec F, Raymond E, Noel K, Cvitkovic E, Herait P, Bertoni F, Riveiro ME. Astorgues-Xerri L, et al. Leuk Lymphoma. 2019 Dec;60(12):3067-3070. doi: 10.1080/10428194.2019.1617860. Epub 2019 Jun 17. Leuk Lymphoma. 2019. PMID: 31204545 No abstract available.
Phase I safety and pharmacodynamic of inecalcitol, a novel VDR agonist with docetaxel in metastatic castration-resistant prostate cancer patients.
Medioni J, Deplanque G, Ferrero JM, Maurina T, Rodier JM, Raymond E, Allyon J, Maruani G, Houillier P, Mackenzie S, Renaux S, Dufour-Lamartinie JF, Elaidi R, Lerest C, Oudard S. Medioni J, et al. Clin Cancer Res. 2014 Sep 1;20(17):4471-7. doi: 10.1158/1078-0432.CCR-13-3247. Epub 2014 Jul 10. Clin Cancer Res. 2014. PMID: 25013124 Clinical Trial.
Phase II study of oxaliplatin and fluorouracil in taxane- and anthracycline-pretreated breast cancer patients.
Zelek L, Cottu P, Tubiana-Hulin M, Vannetzel JM, Chollet P, Misset JL, Chouaki N, Marty M, Gamelin E, Culine S, Dieras V, Mackenzie S, Spielmann M. Zelek L, et al. J Clin Oncol. 2002 May 15;20(10):2551-8. doi: 10.1200/JCO.2002.06.164. J Clin Oncol. 2002. PMID: 12011135 Clinical Trial.
Phase II study of oxaliplatin versus oxaliplatin combined with infusional 5-fluorouracil in hormone refractory metastatic prostate cancer patients.
Droz JP, Muracciole X, Mottet N, Ould Kaci M, Vannetzel JM, Albin N, Culine S, Rodier JM, Misset JL, Mackenzie S, Cvitkovic E, Benoit G. Droz JP, et al. Ann Oncol. 2003 Aug;14(8):1291-8. doi: 10.1093/annonc/mdg342. Ann Oncol. 2003. PMID: 12881395 Clinical Trial.
Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer.
Civenni G, Bosotti R, Timpanaro A, Vàzquez R, Merulla J, Pandit S, Rossi S, Albino D, Allegrini S, Mitra A, Mapelli SN, Vierling L, Giurdanella M, Marchetti M, Paganoni A, Rinaldi A, Losa M, Mira-Catò E, D'Antuono R, Morone D, Rezai K, D'Ambrosio G, Ouafik L, Mackenzie S, Riveiro ME, Cvitkovic E, Carbone GM, Catapano CV. Civenni G, et al. Cell Metab. 2019 Aug 6;30(2):303-318.e6. doi: 10.1016/j.cmet.2019.05.004. Epub 2019 May 23. Cell Metab. 2019. PMID: 31130467
Parathyroid hormone-related protein and human papillomavirus in gynecological tumors.
Mackenzie SL, Gillespie MT, Scurry JP, Planner RS, Martin TJ, Danks JA. Mackenzie SL, et al. Int J Cancer. 1994 Feb 1;56(3):324-30. doi: 10.1002/ijc.2910560305. Int J Cancer. 1994. PMID: 8314318
Polarized Trout Epithelial Cells Regulate Transepithelial Electrical Resistance, Gene Expression, and the Phosphoproteome in Response to Viral Infection.
Mandal SC, Weidmann M, Albalat A, Carrick E, Morro B, MacKenzie S. Mandal SC, et al. Among authors: mackenzie s. Front Immunol. 2020 Aug 14;11:1809. doi: 10.3389/fimmu.2020.01809. eCollection 2020. Front Immunol. 2020. PMID: 32922394 Free PMC article.
Plant science decadal vision 2020-2030: Reimagining the potential of plants for a healthy and sustainable future.
Henkhaus N, Bartlett M, Gang D, Grumet R, Jordon-Thaden I, Lorence A, Lyons E, Miller S, Murray S, Nelson A, Specht C, Tyler B, Wentworth T, Ackerly D, Baltensperger D, Benfey P, Birchler J, Chellamma S, Crowder R, Donoghue M, Dundore-Arias JP, Fletcher J, Fraser V, Gillespie K, Guralnick L, Haswell E, Hunter M, Kaeppler S, Kepinski S, Li FW, Mackenzie S, McDade L, Min Y, Nemhauser J, Pearson B, Petracek P, Rogers K, Sakai A, Sickler D, Taylor C, Wayne L, Wendroth O, Zapata F, Stern D. Henkhaus N, et al. Among authors: mackenzie s. Plant Direct. 2020 Sep 1;4(8):e00252. doi: 10.1002/pld3.252. eCollection 2020 Aug. Plant Direct. 2020. PMID: 32904806 Free PMC article.
Free electron laser infrared action spectroscopy of nitrous oxide binding to platinum clusters, Ptn(N2O).
Meizyte G , Green AE , Gentleman AS , Schaller S , Schöllkopf W , Fielicke A , Mackenzie SR . Meizyte G , et al. Among authors: mackenzie sr. Phys Chem Chem Phys. 2020 Sep 7;22(33):18606-18613. doi: 10.1039/d0cp02800b. Epub 2020 Aug 12. Phys Chem Chem Phys. 2020. PMID: 32785404
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